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  1. Access a sample and characterization.

  2. Click the All tab or the Physico-Chemical Characterizations tab and click Add next to Physico-chemical Characterization.

  3. Both tabs display multiple sections, but All provides provide customizations based on your selected Characterization Type* selection.

  4. Follow these steps to fill in the characterization. Links are provided for additional details.

    Anchor
    AddPhysicoChemical
    AddPhysicoChemical

    SectionWhat to Do
    Physico-Chemical CharacterizationFill in the general information about the characterization.
    [Characterization ] PropertiesDisplays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable.
    Design and MethodsComplete the fields describing techniques and instruments used to derive the data.
    Finding

    Add data findings and supporting documentation relating to the sample.

    Analysis and ConclusionsEnter any relevant analyses and conclusions reached by the data.
    Copy to other Samples...Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

  5. When you finish, click Submit to save the data to the sample.

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FieldDescription
Characterization Type*

The Characterization Type is already selected as Physico-Chemical Characterization.

Characterization Name*

You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type.

  • To select an existing, non-standard Assay Type, based on Characterization Type, select other_pc.
  • To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add.  The new characterization is added the Characterization Name list.
    Adding a New Characterization Name
Assay Type

The field populates automatically with your selection in Characterization Name.

  • With Characterization Name, other_pc, select from existing, non-standard Assay Types.
  • With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – VersionIf this field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Characterization SourceSelect from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization DateSelect from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define Physico-Chemical Properties.

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Physico-Chemical Characterization Properties
Physico-Chemical Characterization Properties
Defining Physico-Chemical [Characterization] Properties

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CharacterizationProperty FieldsField Options

Physical State

Type

Select the appropriate type from among the following options:

Shape Properties

Type (required)

Select from the drop-down list the appropriate shape type:

Shape Properties

Aspect Ratio

Enter the shape aspect ratio.

Shape Properties

Minimum,/Maximum Dimensions

Enter the minimum and maximum dimensions of the sample, as well as the units of measurement.

Solubility Properties

Solvent

Select from the options or enter the name.

  • alcohol
  • phosphate-buffered saline
  • saline
  • water
Solubility PropertiesCritical Concentration

Enter appropriate values for the critical concentration, then select the appropriate units for those values.

Solubility PropertiesIs Soluble?Select Yes or No as to whether the solvent is soluble.

Surface Properties

Is Hydrophobic?

Indicate with Yes or No whether the surface is hydrophobic.

Continue to define Physico-Chemical Design and Methods.

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Defining Physico-Chemical Design and Methods

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Include Page
Data and conditions2
Data and conditions2

After adding data and conditions to the sample, continue to add a Physico-Chemical Characterization.

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Adding a File to a Physico-Chemical Characterization

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  1. Access a sample and characterization.

  2. Click the All tab or the In Vitro Characterizations tab and click Add next to In Vitro Characterization.

  3. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* fieldon your Characterization Type* selection.

  4. Follow these steps to fill in the characterization. Links are provided for additional details.

    Anchor
    AddInVitroCharacterization
    AddInVitroCharacterization

    Field/SectionWhat to Do
    In Vitro CharacterizationFill in the general information about the characterization.
    [Characterization ] Properties]Displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable.
    Design and MethodsComplete the fields describing techniques and instruments used to derive the data.
    Finding

    Add data findings and supporting documentation relating to the sample.

    Analysis and ConclusionsEnter any relevant analyses and conclusions reached by the data.
    Copy to Other Samples...Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

  5. When you finish, click Submit to save the data to the sample.

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FieldDescription
Characterization Type*

The Characterization Type is already selected as In Vitro Characterization.

Characterization Name*

You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type.

  • To select an existing, non-standard Assay Type, based on Characterization Type, select other_vt.
  • To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add.  The new characterization is added the Characterization Name list.
    Adding a New Characterization Name
Assay Type

The field populates automatically with options displayed for in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting.

  • With Characterization Name, other_vt, select from existing, non-standard Assay Types.
  • With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – Version

If available, select the protocol from which the data is derived.

  • A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
  • A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
Characterization SourceSelect or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization DateSelect from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

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Assay Type Options for In Vitro Characterizations

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Characterization Selection

Assay Type Corresponding to Characterization

Blood Contact

Cytotoxicity

Immune Cell Function

Oxidative stress

Sterility

Targeting

Cell binding/Internalization

Transfection

Click [Other] to add an assay type.

Continue to define in vitro characterizations.

Defining In Vitro

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Characterization

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Properties

The [Characterization] Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.

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For Targeting, enter the appropriate Cell Line.

Continue to define In Vitro Design and Methods.

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Defining In Vitro Design and Methods

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Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

Continue to define In Vitro Findings.

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Describing Findings for an In Vitro Characterization

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Include Page
Data and conditions2
Data and conditions2
After adding data and conditions to the sample, add an In Vitro Characterization.

Return to top

Adding a File to an In Vitro Characterization

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  1. Access a sample and characterization.

  2. Click the the All tab or the In Vivo Vitro Characterizations tab and click Add next to In Vivo CharacterizationsVitro Characterization.

  3. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* fieldon your Characterization Type* selection.

  4. Follow these steps to fill in the characterization. Links are provided for additional details.

    Field/SectionWhat to Do
    In Vivo CharacterizationFill in the general information about the characterization.
    [Characterization] PropertiesDisplays for in vivo characterizations.
    Design and MethodsComplete the fields describing techniques and instruments used to derive the data.
    Findings

    Add data findings and supporting documentation relating to the sample.

    Analysis and ConclusionsEnter any relevant analyses and conclusions reached by the data.
    Copy to Other Samples...

    Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

  5. When you finish, click Submit to save the data to the sample.

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FieldDescription
Characterization Type*

The Characterization Type is already selected as In Vivo Characterization.

Characterization Name*

You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type.

Info
If you select Pharmacokinetics and Toxicity, there are no customizations on this Characterization page based on either of these selections.
  • To select an existing, non-standard Assay Type, based on Characterization Type, select other_vv or other_ex_vv.
  • To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add.  The new characterization is added the Characterization Name list.
    Adding a New Characterization Name
Assay Type

Leave this blank or select a type.

  • With Characterization Name, other_vv or other_ex_vv, select from existing, non-standard Assay Types.
  • With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – VersionSelect from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Characterization SourceSelect from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization DateSelect from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define In Vivo Design and Methods.

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Defining In Vivo Design and Methods

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Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

Continue to define In Vivo Findings.

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Describing Findings for In Vivo Characterizations

In the Finding sections, add one or more publications relevant to the sample, as well as data derived for the sample. Add as many files and derived data as you wish add derived data without adding files.Complete the instructions as described in Adding Data and Conditions and Adding a File.

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Adding Data and Conditions to an In Vivo Characterization

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