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  1. Access a sample and characterization.

  2. Click the All tab or the Physico-Chemical Characterizations tab and click Add next to Physico-chemical Characterization.

  3. Both tabs provide customizations based on your Characterization Type* selection.

  4. Follow these steps to fill in the characterization. Links are provided for additional details.

    Anchor
    AddPhysicoChemical
    AddPhysicoChemical

SectionStep...What to Do...
Physico-Chemical CharacterizationFill in the general information about the characterization.
Characterization Properties

If you select one of the following characterization types, you need to fill in additional properties.

  • Physical State
  • Shape
  • Solubility
  • Surface
Design and MethodsComplete the fields describing techniques and instruments used to derive the data.
Finding Info

Add data findings and supporting documentation relating to the sample.

In the Finding section, you

can also add a file to a physico-chemical characterization.

Analysis and ConclusionsEnter any relevant analyses and conclusions reached by the data.

Copy to Other Samples...with the Same Primary Organization

Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

...

Defining the Physico-Chemical Characterization

Fill in Define the following characterization information.

Complete...How to...FieldDescription
Characterization Type*

Characterization Type is already selected Select the type of characterization, such as Physico-Chemical Characterization (required).

Characterization Name*

Select the name of the characterization (required).

Assay Type

The field populates automatically based on Characterization Name selectionselected.

To create a new, non-standard Assay Type

  • Select other.
  • Enter a New Assay Type, and click Add. 
  • The new Assay Type is added to the list.
Protocol Name – VersionIf available, select a protocol from which the data is derived. If displayed, click the hyperlink to the protocol text file to open or save the file.
Characterization SourceSelect or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization DateSelect or enter the date the characterization was made (dd/mm/yyyy).

Anchor
Physico-Chemical Characterization Properties
Physico-Chemical Characterization Properties
Defining Physico-Chemical

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Characterization Properties

The Characterization Properties section opens only for the characterizations If you selected one of the Characterization Types listed in the following table below. Fill in , the following Properties information, as needed Properties section opens, and you must fill in additional information.

Critical Concentration critical concentrationSelect as is soluble
Characterization Property FieldsTypeProperties to CompleteField Options

Physical State

Type

Select the appropriate type Type of physical state.

Shape

Properties

Type (required)

  1. Select the
appropriate
  1. Type of shape
type
  1. .

Shape Properties

  1. Enter the shape Aspect Ratio.
  2. Enter the
shape aspect ratio.

Shape Properties

Minimum,/
  1. Minimum and Maximum Dimensions
Enter
  1. of the
minimum and maximum dimensions of the sample, as well as
  1. sample, and the units of measurement.

Solubility

PropertiesSolvent

  1. Select from the options or enter the name of the Solvent.
    • 3D-cube
    • 3D-cylinder
    • alcohol
    • phosphate-buffered saline
    • saline
    • THF
    • water
Solubility Properties
  2. Enter appropriate values for the
  1. Critical Concentration, then select the appropriate units for those values.
Solubility PropertiesIs Soluble?
  1. Specify Yes or No
  1. to indicate whether the solvent
  1. Is Soluble?.

Surface

Properties

Is Hydrophobic?

Specify Indicate with Yes or No to indicate whether the surface is hydrophobic Is Hydrophobic?.

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Defining Physico-Chemical Design and Methods

Fill in Define the following Design and Methods information as needed.

Design and Methods FieldDescription

Design and Methods Description

Enter a description for the characterization design and methods.

Info
titleExtra lines add

If you include an extra line between text in the Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

Include Page
Technique and instrument
Technique and instrument

Technique*

Include Page
Technique
Technique

Abbreviation

Include Page
Abbreviation
Abbreviation

DescriptionEnter a description of the technical and instrument.
Instrument

Include Page
Instrument
Instrument

...

Click Add to expand the section, then add data and conditions and add a file.

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Adding Data and Conditions for a Physico-Chemical Characterization

...

  1. Access a sample and characterization.

  2. Click the All tab or the In Vitro Characterizations tab and click Add next to In Vitro Characterization.

  3. Both tabs provide customizations based on your Characterization Type* selection.

  4. Follow these steps to fill in the characterization. Links are provided for additional details.

    Anchor
    AddInVitroCharacterization
    AddInVitroCharacterization

    Field/Section
Step...What to Do...
In Vitro CharacterizationFill in the general information about the characterization.
Characterization Properties

...

If you select one of the following characterization types, you need to fill in additional properties.

  • Cytotoxicity
  • Enzyme Induction
  • Transfection
Design and MethodsComplete the fields describing techniques and instruments used to derive the data.
Finding Info

Add data findings and supporting documentation relating to the sample.

In the Finding section, you can also add a file to an in vitro characterization.

Analysis and ConclusionsEnter any relevant analyses and conclusions reached by the data.
Copy to Other Samples...with the Same Primary OrganizationSelect samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you are finished, click Submit to save the data to the sample.

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Defining an In Vitro Characterization

Fill in the following characterization information.

Complete...How to...FieldDescription
Characterization Type*

The Characterization Type is already selected Select a characterization type, such as In Vitro Characterization (required).

Characterization Name*

Select the name of the characterization (required).

Assay Type

The field populates automatically based on Characterization Name selection.

  • Blood Contact
  • Cytotoxicity
  • Enzyme Induction
  • Immune Cell Function
  • Metabolic Stability
  • Oxidative stress
  • Sterility
  • Targeting
  • Transfection
  • other
  • other_vt


    1. Select other to add an assay type

To create a new, non-standard Assay Type

Select other
    1. .
    2. Enter a New Assay Type, and click Add. 
    3. The new Assay Type is added to the list.
Protocol Name – Version

If available, select the protocol from which the data is derived.

  • A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
  • A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
Characterization SourceSelect or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization DateSelect or enter the date the characterization was made (dd/mm/yyyy).

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...

Defining In Vitro

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Characterization Properties

If you selected Specify one of the following in vitro Assay Type options or select Other to open a window where you can add a new assay type.

...

Characterization Selection

...

Assay Type Corresponding to Characterization

...

Blood Contact

...

...

Cytotoxicity

...

...

Immune Cell Function

...

...

Oxidative stress

...

...

Sterility

...

...

Targeting

...

Cell binding/Internalization

...

Transfection

...

Click [Other] to add an assay type.

Characterization Names listed in the following table, the Properties section opens, and you must fill in additional information.

Characterization NameProperties to Complete

Cytotoxicity

Enter

Defining In Vitro Characterization Properties

The Characterization Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.

...

the appropriate Cell Line.

...

Enzyme Induction

...

Enter the Enzyme Name of your choice.

...

TargetingEnter

...

the appropriate Cell Line.

...

Transfection

Enter the appropriate Cell Line.

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Defining In Vitro Design and Methods

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