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This section introduces general caIntegrator procedures and how to obtain help to use caIntegrator.
Topics in this chaptersection include:

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About caIntegrator

NCI, Center for Biomedical informatics and Information Technology (CBIIT) is developing a novel translational informatics platform called

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caIntegrator that allows researchers and bioinformaticians to access and analyze subject annotation and experimental data across multiple subject annotation trials and studies. The caIntegrator framework provides a mechanism for integrating and aggregating biomedical research data and provides access to a variety of data types (e.g. Immunohistochemistry (IHC), microarray-based gene expression, SNPs, subject annotation trials data, etc.) in a cohesive fashion.
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caIntegrator is a web based or locally installed portal that allows researchers and study managers to access the biomedical informatics infrastructure and data analysis tools established by caIntegrator from one common software platform. As a caIntegrator user, you can perform the following tasks:

  • Integrate subject annotation data with genomic and/or imaging data
  • Import data of various types in a predefined flat format, and create new studies with multiple study data
  • Update an existing study to add new attributes or to add/modify data
  • Perform analyses on study data

Registering as a New caIntegrator User

To request a caIntegrator usercaIntegrator:requesting user account; account, requesting new user;registering new user account, you must register as a new user, completing the following steps:

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At this point, an email containing all of the information you specified in the new user request form is sent to the caIntegrator system administrator and an account request confirmation email is also sent to you, the prospective user, at your specified email address. In response, the caIntegrator system administrator uses UPT to create your user account and assign the requested roles (in predefined groups like Study Investigator). When your account is created, the system administrator sends you an email to alert you, after which you can login to caIntegrator.
When your account is registered, the user ID and password you are assigned determine your access rights for the software.

Welcome to the caIntegrator Workspace

The caIntegrator:workspacecaIntegrator:using workspacecaIntegrator Welcome workspace enables quick access to all caIntegrator functions and information before you login. The Welcome page also displays after you log in, before you open any studies ().

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To access caIntegrator functions, use the options listed on the left sidebar of the workspace.

caIntegrator Functions

Once a study is created, its caIntegrator sidebar on the left side of the page. The following table describes each caIntegrator option in the workspace ().

Sidebar Option

Function

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[Study Name]

When you log in, one study displays in the left sidebar by default. Any study that you select in the My Studies drop-down list in the upper right of the page replaces this default selection.

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Home

Click this to return to the home page for the selected study.

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Search [Study Name]

Click this option to open the Search [Study Name] page from which you can launch queries into your selected study. For more information, see .

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Study Data

Click Saved Queries > My Queries to open the list of previous queries you saved. Click any item in the list to open the saved query, which displays on the Criteria, Columns and Sorting tabs. From those tabs, you can modify criteria and/or launch the query again. For more information, see on page 62.
Click Saved Lists > Global Lists or > My Lists to open gene lists that have been saved for a study. From any page in caIntegrator that shows such a group, you can save a such a list of genes to be used for searches or analyses. See on page 69.
Click Saved Copy Number Analysis to open an Edit GISTIC Analysis page. You can review genes retrived from the analysis or, with appropriate permissions, you can edit the metadata for the analysis. See on page 74.

Analysis Tools

Click any of the listed options to open a page where you can launch an analysis of the data in the selected study.

  • Generate a K-M Plot. See on page 82.
  • Generate a Gene Expression Plots. See on page 88.
  • Launch GenePattern Analysis. on page 101.

Study Management

Click either of the listed options to manage the selected study through editing or deleting it or by creating a new study.

  • Click Manage Studies. See on page 45.
  • Click Create a New Study. See on page 16.

Application Management

Click Manage Platforms to identify, add or remove platforms that caIntegrator supports. For more information, see on page 47.

caIntegrator Menu

  • Click Support to view contact information for Application Support.
  • Click Tutorials to view a tutorial to help you get started using caIntegrator.
  • Click User Guide to open the caIntegrator v.1.3 User's Guide in PDF format.

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  • the logo for the selected study (if it exists)
  • the name for the selected study
  • the list of saved queries and/or saved lists for that study

Viewing Existing Studies

If you have not logged into caIntegrator, you can view any public studies in your browser. After logging in, you can view existing studies for which you have been granted permission. In the upper right corner of the page, in the My Studies drop down list, select the study you want to review or work in.

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  • Because in looking at the study, you may not know the meaning of all the annotations, you can open a reference page with a summary of the annotations. Click the Data Dictionary: View link on the study home page, as shown in the following screen shot.
  • From the study summary page, you can also open a log for the study. Click the Study Log: View link on the page to see all log entries with descriptions.

Data Dictionary

A link on a study home page, as shown in the following screen shot, opens a data dictionary summary.

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For more information about study details, see on page 17.

Study Log

The study log which you can open by clicking the Study Log > View link on the study summary page lists the steps used to create a study. For more information, see on page 18.

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The user's guide/online help explains how to use all of the features.
To access online help, click the help icon at the top of each page to open a context-sensitive topic. Context-sensitive help displays information that corresponds to the page from which help was opened.

Logging Out

To caIntegrator:logging outlog out of caIntegrator, click the link in the upper right-hand corner of the page.

Application Support

For any general information about the application, application support or to report a bug, contact NCICB Application Support.

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