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Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
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Unknown User (leblancak)

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Otridge, John (NIH/NCI) [C]

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Kim, Erika (NIH/NCI) [E]

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Sommers, Connie (NIH/NCI) [E]

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Debbie Knapp
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Toby HechtX

Unknown User (parchmentr)


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Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

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ItemWhoTalking Points
Discussion of potential submission of FidoCure and Vidium Animal Health data

Sommers, Connie (NIH/NCI) [E] 

  • Previous conversations revealed some issues with analytic techniques
DGAB Updates

Kuffel, Gina (NIH/NCI) [C] 

Recently Approved

  • COTC021
    • "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma"University of Minnesota
    • 152 cases, 93 files (1.54 TB)
    • Full clinical dataset is available for both arms of this trial (324 dogs)
    • Scan H & E is available
    • Status: Approved by SAC on 6/30/23

ICDC Studies in Active Submission

  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Data has been loaded to the Dev tier
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

  • 2022 BPSC Review Article

    The manuscript entitled "Leading the Pack: Best Practices in Comparative Canine Cancer Genomics to Inform Human Oncology" has been successfully submitted online and is being delivered to the Editorial Office of Veterinary and Comparative Oncology for consideration.

Upcoming Steering Committee Meeting

Unknown User (parchmentr)

  • Enter date: Wednesday 7/26, no August Meeting
  • Toby is unavailable at 12:30 pm, proposing change to 11 or 11:30 am
  • Proposed Agenda:
Next Software Release

Kuffel, Gina (NIH/NCI) [C] 

  • Target date is July 26, 2023
  • New Features
    • 2 new tabs on the Study Details page, one for supporting data and the other for clinical data observations
    • Full-text search for JBrowse
    • Liftover tracks for gene annotations from human hg38 to canFam genomes
    • Updated UI design for "My Files" Cart Page
    • Button for exporting a file manifest directly to the CGC

Minutes (Not Verbatim)

AL - Jerry Post agreed that it is an exciting time for canine oncology. He thinks it would be a good idea for us to connect more. He expressed some concerns with integrating their data with our committee. They have novel data that would be interesting for the ICDC. Vidium has a publication out and may be more willing to share data.

TH - We should schedule a formal session with both groups to reconnect.

TH - Debbie has been in touch and has a paper that has been accepted that actually uses ICDC data.






Previous ICDC Use Cases from Steering Committee

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8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

TH - Look at drug responses and the tumor itself to determine if there is a biomarker based on genomic expression. In the Intro of the BPSC paper, we could give examples of things that can be done based upon existing drug trial studies. 

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DK - Pre and post biopsies were attempted in Vemurafinib trial

AL - Until we have DBs to refer to and a more stable reference genome it is difficult to make progress.




Action items

  •  Debbie to write invitation for Jaime Modiano
  •  Revisit new steering committee members in September 
  •  Debbie Knapp to send an email to FidoCure and Vidium to see if these groups are willing to sit down and meet with us.