Summary

The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):

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• Images contained in "RIDER Lung CT" Collection in NBIA
• Repeat CT Measurements: Human subjects: Lung
• Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls
• Download the related publication: Zhaob-RepeatCT Radiology2009.pdf

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• Images contained in "Phantom" Collection in NBIA
• Repeat measurements: PET/CT phantoms

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• Images contained in "RIDER Lung PET CT" Collection in NBIA
• Longitudinal PET/CT human studies: Lung

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• Images contained in "RIDER Neuro MRI" Collection in NBIA
• Repeat human subject studies: Neuro
• Dynamic Contract Enhanced studies: DCE MRI:
• Diffusion weighted imaging: DWI MR
• Diffusion tensor imaging: DT MRI.

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• Images contained in "RIDER Breast MRI" Collection in NBIA
• Repeat measurements: Human subjects: Breast
• DCE MRI
• ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.

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• Images contained in "RIDER Phantom MRI" Collection in NBIA
• Repeat measurement: Phantom studies
• DCE MRI
• RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
• RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.

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• NIST has NCI NBIA data and data from other data sources
• See Biochange 2008
• http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm

Data Access

You can view and download these images on NBIA. You do not need to log in unless you want access to advanced features in the site. Simply follow these steps:

• Navigate to http://imaging.nci.nih.gov
• Click the "Search Images" link in the center of the page
• Scroll down through the search criteria until you see the "Collections" section
• Select the check box for whichever RIDER sub-collection you are interested in
• Press "Submit"

This will return the full list of cases included in the collection. To download the associated DICOM images:

• Press the "Check All" button and then "Add to Basket"
• Press the "View My Basket" button at the bottom of the page (or "View Contents" in the left menu bar)
• Press the "Download Manager" button to open a Java applet and specify where you'd like to save your images