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  •  Toby to reach out to Adam Resnick to gauge interest in joining the Subcommittee
  •  Kuffel, Gina (NIH/NCI) [C]  to work with Ralph to get the letters prepared for the new SC members
  •  Kuffel, Gina (NIH/NCI) [C] to build list of studies that used FidoCure data
  •  Revisit new steering committee members in September (loop Connie into this discussion) 
  •  Toby to invite Greg from CCDI to the next Executive Team Meeting in January
  •  Toby to look across the NCI directory to find person that has a combination of canine and pediatric oncology background

Agenda

ItemWhoTalking Points
ICDC Common Data Element (CDE) Mapping Exercise 

Kuffel, Gina (NIH/NCI) [C] 

ICDC Model Properties 2024-05-31 - working copy.xlsx
Recent & Upcoming Presentations

Kuffel, Gina (NIH/NCI) [C] 

New
Steering Committee
Members
Updates
Toby
Ralph
  • New CCDI member to potentially present to Steering Committee, need topics of interest
    • How can we compare pediatric/human data to canine data
    • How can our researchers connect to where related human data are accessible
  • New Members
    • Adam Resnick
    • Anne Avery
  • Potential New Members
    • Marc Ernstoff
Post Discussion about FidoCure

All

  • Not clear if we really can have a successful collaboration, however we have let them know if they can find a way to work with us that the ICDC would be interested.
  • Their public data is a candidate for the ICDC
  • They are interested in correlating data with biomarkers and that is an area of interest for the ICDC
  • Work instead with peer reviewed and published scientists that use FidoCure data
  • Their data may not be useful to predict outcomes
New ICDC
  • July meeting: July 24th 11:30-1 PM 

Longitudinal Data Acquisition and Use Working Group (LDAUWG) Updates

All

  • Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC.

All

  • Working Group Charter 1-pager
  • Last meeting was Friday May 17, 2024
  • Possible collaboration with the Morris Animal Foundation
  • Next meeting is TBD
Data Governance Advisory Board (DGAB) Updates

Kuffel, Gina (NIH/NCI) [C] 

ICDC Incoming Data Submission Requests

  • UC02 - 2020 Ostrander Urothelial Carcinoma study
    • Attempting to get bam files transferred into bucket

ICDC Studies Recently Approved

  • STS01
    • Soft tissue sarcoma study from Colorado State University
    • 29 cases
    • Genomics, Transcriptomics, Immunology 
    • Status: SAC has approved this submission, template-based loading files for metadata received, kickoff call to be scheduled

ICDC Studies in Active Submission 

OSA04 

    • Osteosarcoma study from Auburn University
    • 7 cases
    • Clinical and Transcriptomic data
    • Status: Version 1 of the metadata has been received and loaded to Dev environment.

COTC021 

  • "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 
  • 152 cases
  • Dr. Amy LeBlanc 
  • Status: Since study, case and sample records were loaded in early September a reconciliation was performed to ensure accuracy. Sequencing files and file transfer manifest have been transferred to bucket pending validation. 2 study-level files need to be added to the bucket.

COTC022

  • "A Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma" 
  • 157 cases
  • Status: Sample and file records have been received. The study has been loaded onto the QA environment and is currently in testing.

UBC03 

  • "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" 
  • Dr. Debbie Knapp 
  • Status: All data loading template files, object files, and file transfer manifest have been received, validation is pending. 

OSA02 

  • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
  • 117 cases
  • Dr. Dawn Duval 
  • Status: Template data loading files have been received. The study has been loaded onto the Dev tier. Files from the submitter bucket are being transferred into the ICDC production bucket. 

PRECINCT01 

  • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" 
  • UC Davis 
  • 21 cases 
  • Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team.  

PRECINCT02 

          • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" 
          • Tufts University 
          • 49 cases 
          • Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.  
ICDC Biospecimen Data

Kuffel, Gina (NIH/NCI) [C] 

Upcoming Steering Committee Meeting

Ralph Parchment

July meeting: July 24th 11:30-1 PM 

Upcoming LDAUWG Meeting


TBD

Minutes (Not Verbatim)



Notes on FidoCure

  • Not clear if we really can have a successful collaboration, however we have let them know if they can find a way to work with us that the ICDC would be interested.
  • Their public data is a candidate for the ICDC
  • They are interested in correlating data with biomarkers and that is an area of interest for the ICDC
  • Work instead with peer reviewed and published scientists that use FidoCure data
  • Their data may not be useful to predict outcomes

Previous ICDC Use Cases from Steering Committee

...