Page History

• 4/15/24: CRDC Component Report Out featuring the ICDC
  • CRDC Component Report Out_ICDC_April 2024.pptx
• 5/15/24: The Golden Retriever Lifetime Study featuring Julia Labadie
  • Julia Labadie_MAF_20240515.pptx

• 5/22/24:Dogs and Cancer Part 1: Canine cancer genomics resources and research featuring Cheryl London, Gina Kuffel and Elaine Ostrander

  • https://www.cancergenomicscloud.org/webinars/2024-05-22-webinar
• 6/20/24: Legacy of the domestic dog: informing biological discovery through large-scale genomics featuring Elaine Ostrander
• 6/26/24: Dogs and Cancer Part 2: Emerging methods and technologies in comparative oncology featuring Shaying Zhou and Heather Gardner
  • https://www.cancergenomicscloud.org/webinars/june-webinar

• On 5/15/24: Dr. Julia Labadie, a Principal Investigator at the Morris Animal Foundation (MAF), presented an overview of the Golden Retriever Lifetime Study (GRLS). This landmark longitudinal study, spanning over a decade, has collected biological specimens and health data from over 3,000 Golden Retrievers throughout their lives.
• 6/5/24: Dr. Lee Helman provided valuable insights into the Childhood Cancer Data Initiative (CCDI) and the possibility of leveraging canine models of human disease. This presentation holds immense potential for identifying synergies and collaborative opportunities between the ICDC and the CCDI.
• New CCDI member to potentially present to Steering Committee, need topics of interest
  • How can we compare pediatric/human data to canine data
  • How can our researchers connect to where related human data are accessible
• New Members
  • Adam Resnick
  • Anne Avery
• Potential New Members
  • Marc Ernstoff
• July meeting: July 24th 11:30-1 PM 

Longitudinal Data Acquisition and Use Working Group (LDAUWG) Updates

• Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC.
• Working Group Charter 1-pager
• Last meeting was Friday May 17, 2024
• Possible collaboration with the Morris Animal Foundation
• Next meeting is TBD

ICDC Incoming Data Submission Requests

• UC02 - 2020 Ostrander Urothelial Carcinoma study
  • Attempting to get bam files transferred into bucket

ICDC Studies Recently Approved

• STS01
  • Soft tissue sarcoma study from Colorado State University
  • 29 cases
  • Genomics, Transcriptomics, Immunology 
    
  • Status: SAC has approved this submission, template-based loading files for metadata received, kickoff call to be scheduled

ICDC Studies in Active Submission 

OSA04 

• • Osteosarcoma study from Auburn University
  • 7 cases
  • Clinical and Transcriptomic data
  • Status: Version 1 of the metadata has been received and loaded to Dev environment.

COTC021 

• "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 
• 152 cases
• Dr. Amy LeBlanc 
• Status: Since study, case and sample records were loaded in early September a reconciliation was performed to ensure accuracy. Sequencing files and file transfer manifest have been transferred to bucket pending validation. 2 study-level files need to be added to the bucket.

COTC022

• "A Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma" 
• 157 cases
• Status: Sample and file records have been received. The study has been loaded onto the QA environment and is currently in testing.

UBC03 

• "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" 
• Dr. Debbie Knapp 
• Status: All data loading template files, object files, and file transfer manifest have been received, validation is pending. 

OSA02 

• "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
• 117 cases
• Dr. Dawn Duval 
• Status: Template data loading files have been received. The study has been loaded onto the Dev tier. Files from the submitter bucket are being transferred into the ICDC production bucket. 

PRECINCT01 

• "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" 
• UC Davis 
• 21 cases 
• Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team.  

PRECINCT02 

• • • • • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" 
        • Tufts University 
        • 49 cases 
        • Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.  

• Collect biospecimen data so that we can build a page in the ICDC application
• ICDC Biospecimen Data

TBD