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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it It has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 125,000 out of the 178,080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (24.07E10d: July October 2024)

Image AddedImage Removed

NCIt concepts with tagged synonyms from each outside source (24.07E10d: July October 2024)

NCIt Concepts

Source

3ACC
1182ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

2811330030CDISC
799841CDISC-GLOSS
24702468Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
428426CTEP
2860628950CTRP
636DIPG/DMG
1076EDQM-HC
2888228973FDA
239GAIA
1250512575GDC
16491651HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5660mCode
1281MedDRA
150152MRCT-Ctr
23NAACCR
246NCCN
510480NCPDP
6NDC
4783NICHD
826OORO
71ORCHESTRA
18621861PCDC
40PI-RADS
211PRO-CTCAE
377SEER
662SeroNet
344UBERON
284286UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported. 

NCIm sources and the number of concepts to which each contributes (202402202408: February August 2024)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 20232024_12D06D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 20232024_12D06D
27BRIDGBiomedical Research Integrated Domain Group Model, 20232024_12D06D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 20232024_12D06D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 20232024_12D06D
1930420456caDSRCancer Data Standards Registry and Repository, 20232024_12D06D
407CARELEXContent Archive Resource Exchange Lexicon, 20232024_12D06D
53CBDDChemical Biology and Drug Development Vocabulary, 20232024_12D06D
265CCPSChildhood Cancer Predisposition Study, 20232024_12D06D
922CDCU.S. Centers for Disease Control and Prevention, 20232024_12D06D
2901929309CDISCClinical Data Interchange Standards Consortium, 20232024_12D06D
800CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 20232024_12D06D

24252485

CELLOSAURUSCellosaurus, 20232024_12D06D
36803678CPTACClinical Proteomic Tumor Analysis Consortium, 20232024_12D06D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 20232024_12D06D
775CTCAECommon Terminology Criteria for Adverse Events, 20232024_12D06D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 20232024_12D06D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 20232024_12D06D
276CTDCClinical Trial Data Commons, 20232024_12D06D
372373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 20232024_12D06D
2802328536CTRPClinical Trials Reporting Program, 20232024_12D06D
904DCPNCI Division of Cancer Prevention Program, 20232024_12D06D
114DICOMDigital Imaging Communications in Medicine, 20232024_12D06D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 20232024_12D06D
694DTPNCI Developmental Therapeutics Program, 20232024_12D06D
10701076EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 20232024_12D06D
2735527764FDAU.S. Food and Drug Administration, 20232024_12D06D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 20232024_12D06D
60306092GDCNCI Genomic Data Commons, 20232024_12D06D
281GENCGeopolitical Entities, Names, and Codes Standard, 20232024_12D06D
14391648HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 20232024_12D06D
106ICD-10International Classification of Diseases, 10th Edition, 20232024_12D06D
693ICDCNCI Integrated Canine Data Commons, 20232024_12D06D
215ICHInternational Conference on Harmonization, 20232024_12D06D
215INCInternational Neonatal Consortium, 20232024_12D06D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 20232024_12D06D
244KEGGKEGG Pathway Database, 20232024_12D06D
56605661mCodeMinimal Common Oncology Data Elements, 20232024_12D06D
183778187216NCINational Cancer Institute Thesaurus, 2023_12D2024_06D
150MRCT-CtrMRCT Center Clinical Research Plain Language Glossary, 2024_06D
5079NCI-GLOSSNCI Dictionary of Cancer Terms, 20232024_12D06D
58606004NCI-HGNCNCI HUGO Gene Nomenclature Committee, 20232024_12D06D
129NCI-HL7NCI Health Level 7, 20232024_12D06D
509NCPDPNational Council for Prescription Drug Programs, 20232024_12D06D
5NDCNational Drug Code, 20232024_12D06D
47804779NICHDNational Institute of Child Health and Human Development, 20232024_12D06D
825OOROOperational Ontology for Radiation Oncology, 20232024_12D06D
70ORCHESTRAORCHESTRA, 20232024_12D06D
18321831PCDCPediatric Cancer Data Commons, 20232024_12D06D
39PI-RADSProstate Imaging Reporting and Data System, 20232024_12D06D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2023_12D2024_06D
210PRO-CTCAEPatient Reported Outcomes version of Common Terminology Criteria for Adverse Events, 2024_06D
310RENIRegistry Nomenclature Information System, 20232024_12D06D
659SeroNetSerological Sciences Network Terminology, 20232024_12D06D
236UBERONUBERON Ontology, 20232024_12D06D
15461557UCUMUnified Code for Units of Measure, 20232024_12D06D
7778WHOWorld Health Organization (WHO) Terminology, 20232024_12D06D
25ZFINZebrafish Model Organism Database, 20232024_12D06D

NCIm concepts

Source Label - Other

Source Name

1588415885AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13257CBOClinical Bioinformatics Ontology, 2011_02
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 20232024
357CCSR_ICD10PCSClinical Classifications Software Refined for ICD-10-PCS, 20232024
962CDCRECRace & Ethnicity - CDC, 1.2
30803081COSTARCOSTAR, 1989-1995
1648516483CSPCRISP Thesaurus, 2006
3839CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
618642CVXVaccines Administered, 20172024_02_08, 2023_08_1615
1239211414DRUGBANKDrugBank, 5.0_20232024_0802_1109
72907289DXPDXplain, 1994
102551102550FMAFoundational Model of Anatomy Ontology, 4_15
74827480GARDGenetic and Rare Diseases Information Center, 2015_04
7188171878GOGene Ontology, 2023_05_10
80818457HCPCSHealthcare Common Procedure Coding System, 20232024
43627HGNCHUGO Gene Nomenclature Committee, 2023_04
90789077HL7V3.0HL7 Vocabulary Version 3.0, 2023_0211
1923519432HPOHuman Phenotype Ontology, 2023_0710_2109
1741617415ICD10ICD10, 2016
105376105371ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification, 2024
191545ICD10PCSICD-10-PCS, 2024
2088620887ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
28642861ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
175623177072LNCLOINC, 276277
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
6209362725MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA), 2627_10
35233559MED-RTMedication Reference Terminology, 20232024_0903_0504
21232120MEDLINEPLUSMedlinePlus Health Topics, 20221101
900901MGEDMGED Ontology, 131
456461457042MSHMedical Subject Headings, 2024_20232024_0802_0301
21896121941MTHUMLS Metathesaurus, 2023AB2024AA
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2020
1900719008MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
5739157707MTHSPLMetathesaurus FDA Structured Product Labels, 20232024_0802_24
88MVXManufacturers of Vaccines, 20232024_0902_0612
719490722235NCBINCBI Taxonomy, 2023_0411_1301
953210188NCIMTHNCIMTH
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
103963105235OMIMOnline Mendelian Inheritance in Man, 20232024_0802_1012
1239912396PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
270279PNDSPerioperative Nursing Data Set, 20212024
940QMRQuick Medical Reference (QMR), 1996
4582645821RADLEXRadLex, 4_1
217864219001RXNORMRxNorm Vocabulary, 20AA_230905F240304F
361058363404SNOMEDCT_USUS Edition of SNOMED CT, 20232024_0903_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
230234SRCMetathesaurus Source Terminology Names
2910429105UMDUMDNS: product category thesaurus, 2023
50025009USPUSP Compendial Nomenclature, 20232024_01_08_17
16051688USPMGUSP Medicare Model Guidelines, 20202023
61107UWDAUniversity of Washington Digital Anatomist, 1.7.3
3833438761VANDFVeterans Health Administration National Drug File, 20232024_0701_31

Overall Counts (February August 2024)

ConceptsRelationships Attributes Total Number of Terms
2,684696,035773

23,500619,918364

 24 26,395334,137483 77,098164,885803