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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 years, it It has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 50125,000 out of the 120178,000 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1924.12e07E: December 2019July 2024)

Image RemovedImage Added

NCIt concepts with tagged synonyms from each outside source (1324.03d07E: March 2013July 2024)

1,149

NCIt Concepts

Source

3
335

BIOCARTA

ACC
1182ACC/AHA
2016

BRIDG

1148BRIDG 3.0.3
27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

408CareLex
56CBDD
268

CCPS

28113CDISC
799CDISC-GLOSS
2470Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
428CTEP
28606CTRP
636DIPG/DMG
1076EDQM-HC
28882FDA
239GAIA
12505GDC
1649HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5660mCode
1281MedDRA
150MRCT-Ctr
23NAACCR
246NCCN
510NCPDP
6NDC
4783NICHD
826OORO
71ORCHESTRA
1862PCDC
40PI-RADS
211PRO-CTCAE
377SEER
662SeroNet
344UBERON
284UCUM
25
ZFin

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported. 

NCIm sources and the number of concepts to which each contributes (201908202408:  August 2019August 2024)

1149    201907E20    2019_07E201 International Neonatal 201907E156 Jackson Laboratories 201907E244  Pathway Database, 2019_07E5077  of Cancer 201907E5001  201907E129  201907E540  Council for 201907E   201907E4782    2019_07E39    201907E169    , 2019_07E310    , 2019_07E1361    2019_07E 25   201907E

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2024_06D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2024_06D
27BRIDGBiomedical Research Integrated Domain Group Model, 2024_06D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2024_06D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2024_06D
20456caDSRCancer Data Standards Registry and Repository, 2024_06D
334

BioC

BioCarta online maps of molecular pathways, adapted for NCI use, 2019_07E
407CARELEXContent Archive   Resource Exchange Lexicon, 20192024_07E06D40
53CBDDChemical Biology and Biology and Drug Development Vocabulary, 2019_07E923, 2024_06D
265CCPSChildhood Cancer Predisposition Study, 2024_06D
922CDCU.S. Centers for   Disease Control and Prevention, 20192024_07E06D714
29309CDISC-GLOSSClinical Data   Interchange Standards Consortium Glossary Terms, 20192024_07E06D21313
800CDISC-GLOSSClinical Data   Interchange Standards Consortium , 2019_07E3657Glossary Terms, 2024_06D

2485

CELLOSAURUSCellosaurus, 2024_06D
3678CPTACClinical Proteomic   Tumor Analysis Consortium, 20192024_07E06D
406CRCHCancer Research   Center of Hawaii Nutrition Terminology, 2019_07E2024_06D
775CTCAECommon Terminology Criteria for Adverse Events, 2024_06D
5599CTCAE_3Common Terminology   Criteria for Adverse Events 3.0, 20192024_07E06D
4022CTCAE_5Common Terminology   Criteria for Adverse Events 5.0, 20192024_07E06D
770276CTCAECTDCClinical Trial Data Commons, 2024_06DCommon Terminology   Criteria for Adverse Events, 2019_07E
373CTEP-SDCCancer Therapy   Evaluation Program - Simple Disease Classification, 20192024_07E06D
2134328536CTRPClinical Trials   Reporting Program, 20192024_07E06D
903904DCPNCI Division of   Cancer Prevention Program, 20192024_07E06D
114DICOMDigital Imaging   Communications in Medicine, 2019_07E2024_06D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2024_06D
694DTPNCI Developmental   Therapeutics Program, 20192024_07E06D
10091076EDQM-HCEuropean   Directorate for the Quality of Medicines & Healthcare, 20192024_07E06D
2185727764FDAU.S. Food and Drug   Administration, 20192024_07E06D
207GAIAGlobal Alignment of   Immunization Safety Assessment in pregnancy, 2019_07E2024_06D
6092GDCNCI Genomic Data Commons, 2024_06D
281GENCGeopolitical   Entities, Names, and Codes Standard, 2019_07E2024_06D
1648HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2024_06D
106ICD-10International Classification of Diseases, 10th Edition, 2024_06D
693ICDCNCI Integrated Canine Data Commons, 2024_06D
215ICHInternational   Conference on Harmonization, 20192024_07E06D
215INCInternational Neonatal Consortium, 2024_06D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2024_06D
244KEGGKEGG Pathway Database, 2024_06D
5661mCodeMinimal Common Oncology Data Elements, 2024_06D
187216NCINational Cancer Institute Thesaurus, 2024_06D
150MRCT-CtrMRCT Center Clinical Research Plain Language Glossary, 2024_06D
5079NCI-GLOSSNCI Dictionary of Cancer Terms, 2024_06D
6004NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2024_06D
129NCI-HL7NCI Health Level 7, 2024_
146328NCINational Cancer Institute Thesaurus, 2019_07E
06D
509NCPDPNational Council for Prescription Drug Programs, 2024_06D
5NDCNational Drug Code, 2024_06D
4779NICHDNational Institute of Child Health and Human Development, 2024_06D
825OOROOperational Ontology for Radiation Oncology, 2024_06D
70ORCHESTRAORCHESTRA, 2024_06D
1831PCDCPediatric Cancer Data Commons, 2024_06D
39PI-RADSProstate Imaging Reporting and Data System, 2024_06D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2024_06D
210PRO-CTCAEPatient Reported Outcomes version of Common Terminology Criteria for Adverse Events, 2024_06D
310RENIRegistry Nomenclature Information System, 2024_06D
659SeroNetSerological Sciences Network Terminology, 2024_06D
236UBERONUBERON Ontology, 2024_06D
1557UCUMUnified Code for Units of Measure, 2024_06D
78WHOWorld Health Organization (WHO) Terminology, 2024_06D
25ZFINZebrafish Model Organism Database, 2024_06D

NCIm concepts

Source Label - Other

Source Name

15,873
15885AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
622
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2024
357CCSR_ICD10PCSClinical Classifications Software
, 20053,080
Refined for ICD-10-PCS, 2024
962CDCRECRace & Ethnicity - CDC, 1.2
3081COSTARCOSTAR, 1989-1995
16,501
16483CSPCRISP Thesaurus, 2006
3,843
3839CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
435
642CVXVaccines
 
Administered,
2018
2024_
10_18, 2019_03_047,711
02_15
12392DRUGBANKDrugBank,
 
5.0_
2016
2024_
06_22, 5.0_2019_01_317,293
02_09
7289DXPDXplain, 1994
102,404
102550FMAFoundational Model
 
of Anatomy Ontology, 4_
10
15
7,503
7480GARDGenetic and Rare
 
Diseases Information Center, 2015_04
70,289
71878GOGene Ontology,
  2018
2023_05_
20
10
6,655
8457HCPCSHealthcare Common
 
Procedure Coding System,
2019
2024
41,301
43627HGNCHUGO Gene
 
Nomenclature Committee,
2018
2023_
03
04
9,789
9077HL7V3.0HL7 Vocabulary
 
Version 3.0,
2018
2023_
08
11
15,301
19432HPOHuman Phenotype
 
Ontology,
2018
2023_
11_08102,167
10_09
17415ICD10ICD10, 2016
105371ICD10CMInternational
 
Classification of Diseases, 10th Edition, Clinical Modification,
2019
2024
190,389
191545ICD10PCSICD-10-PCS,
201917,425ICD10ICD10, 201620,941
2024
20887ICD9CMInternational
 
Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2,588
2861ICDOInternational
 
Classification of Disease for Oncology, 3_
1
2
748ICPCInternational
 
Classification of Primary Care, 1993
5,057
5055ISO3166-2International
 
Organization for Standardization 3166-2, 2012
146,331
177072LNCLOINC,
265
277
41MCMMcMaster University
 
Epidemiology Terms, 1992
332MDBCACMitelman Database
 
of Chromosome Aberrations in Cancer, 2005_12
56,014
62725MDRMedical Dictionary
 
for Regulatory Activities Terminology (MedDRA),
22.
27_0
3,315
3559MED-RTMedication
 
Reference Terminology,
2019
2024_03_04
2,119
2120MEDLINEPLUSMedlinePlus Health
 
Topics,
20181108
20221101
900
901MGEDMGED Ontology, 131
373,575 
457042
 MSH
MSHMedical Subject Headings,
2019
2024_2024_
2019
02_01
_079
21941MTHUMLS Metathesaurus, 2024AA
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_
2014
521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021
2020
19008MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
58,600
57707MTHSPLMetathesaurus FDA Structured Product Labels,
2019
2024_02_
22194,860

MTH

UMLS Metathesaurus, 2019AA

76
24
88MVXManufacturers of Vaccines,
2018
2024_
08
02_
31 1,409,501 NCBI
12
722235NCBINCBI Taxonomy,
  2018
2023_
04
11_
19
01
 5,749
10188NCIMTHNCIMTH
NCISEERNCI SEER ICD   Neoplasm Code Mappings, 1999NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_0539,434 NDFRTNational Drug File,   2018_02_051,887 
1887NPO
 NPO
NPO: NanoParticle
 
Ontology for Cancer Nanotechnology Research, 2011_12_08
106,313
105235OMIMOnline Mendelian
 
Inheritance in Man,
2019
2024_02_
04
12
12,399
12396PDQPhysician Data
 
Query, 2016_07_31
2,039
2039PMAPortfolio
 
Management Application, 2010
260
279PNDSPerioperative
 
Nursing Data Set,
4_2018
2024
940QMRQuick Medical
 
Reference (QMR), 1996
45,733
45821RADLEXRadLex,
3
4_
15
1
201,450
219001RXNORMRxNorm Vocabulary,
  18AB
20AA_
190304F
240304F
347030
363404SNOMEDCT_USUS Edition of
 
SNOMED CT,
2019
2024_03_01
162
167SOPSource of Payment
 
Typology,
84,810
9.2
4811SPNStandard Product
 
Nomenclature, 2003
200
234SRCMetathesaurus
 
Source Terminology Names
27,283
29105UMDUMDNS: product
 
category thesaurus,
2019
2023
 1,693
5009
 USPMG
USP
Medicare Model   Guidelines, 2017 4,352
 USP
USP Compendial
 
Nomenclature,
2018
2024_
12_1061,112
01_08
1688USPMGUSP Medicare Model Guidelines, 2023
61107UWDAUniversity of
 
Washington Digital Anatomist, 1.7.3
34,194
38761VANDFVeterans Health
 
Administration National Drug File,
2019
2024_
02
01_
01
31

Overall Counts (August 20192024)

ConceptsRelationships Attributes Total Number of Terms
32,265696,686773

2223,852619,144364

 25 26,184334,657483 77,508164,907803