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On presenting the ACRIN proposal to conduct the CTC trial to the NCI Executive Committee, a case was made that image data sharing, publicly accessible by the National Biomedical Image Archive (NBIA) would be an invaluable research asset to the image processing research community. Adding to the many merits of that proposal, the data-sharing component was strongly endorsed. ACRIN completed the trial expeditiously and its results were published in NEJM in fall 2008 to wide interest . Please see their NEJM publication for their published results and the ACRIN website itself for (N Engl J Med. 2008 Sep 18;359(12):1207-17). The ACRIN website has a more complete protocol description (http://www.acrin.org/TabID/151/Default.aspx). ACRIN has graciously allowed the permitted a wider research community access to a portion of the data from that trial.

The "CT Colonography" (CTC) image collection in DICOM format, PHI de-identified for public download  at download https://imaging.nci.nih.gov/ncia/  contains 825 cases from the optical colonoscopy (OC)-validated , ACRIN clinical trial whose subjects who had same-day sequential CTC followed by OC. The attached documents separately lists OC verified cases that contain: Cases where no polyp was found; 69 cases possessing 6 to 9 mm polyps; and 35 cases that possess at least one polyp "larger than 10 mm." The key to the lesion coding in those XL files is: CTC key to XL colon lesion spreadsheet.docxNote: this collection, as an 825 case subset of the ACRIN 2600+ total cases, proportionally represents roughly the prevalence of polyps found in a general population.