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Access a sample and characterization.
Click All or the Physico-Chemical Characterizations tab and click Add next to Physico-chemical Characterization. Both tabs display five sections, but All provides customizations based what you select in the Characterization Type* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

Anchor

	AddPhysicoChemical
	AddPhysicoChemical

Section	What to Do
Physico-Chemical Characterization	Fill in the general information about the characterization.
[Characterization] Properties	Displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Finding	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to other Samples...	Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

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Include Page

	Other options
	Other options

Field	Description
Characterization Type*	The Characterization Type is already selected as Physico-Chemical Characterization.
Characterization Name*	You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type. To select an existing, non-standard Assay Type, based on Characterization Type, select other_pc. To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list. Image Modified
Assay Type	The field populates automatically with your selection in Characterization Name. With Characterization Name, other_pc, select from existing, non-standard Assay Types. With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – Version	If this field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Characterization Source	Select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization Date	Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define Physico-Chemical Properties.

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	Other options
	Other options

Characterization	Property Fields	Field Options
Physical State	Type	Select the appropriate type from among the following options: colloid-emulsion colloid-gel colloid-sol fluid-gas fluid-liquid fluid-vapor solid-crystal solid-fibril solid-glass solid-granule solid-powder
Shape Properties	Type (required)	Select from the drop-down list the appropriate shape type: 2D-circle 2D-diamond 2D-ellipse 2D-parallelogram 2D-polygon 2D-rectangle 2D-square 2D-trapezoid 2D-triangle 3D-cone 3D-cube 3D-cylinder 3D-disc 3D-fibril 3D-hexadron 3D-needle 3D-oblate spheroid 3D-polyhedron 3D-prolate spheroid 3D-rod 3D-sphere 3D-tetrahedron 3D-tetrapod
Shape Properties	Aspect Ratio	Enter the shape aspect ratio.
Shape Properties	Minimum,/Maximum Dimensions	Enter the minimum and maximum dimensions of the sample, as well as the units of measurement.
Solubility Properties	Solvent	Select from the options or enter the name. alcohol phosphate-buffered saline saline water
Solubility Properties	Critical Concentration	Enter appropriate values for the critical concentration, then select the appropriate units for those values. g/ml mg/ml ug/ml ug/ul
Solubility Properties	Is Soluble?	Select Yes or No as to whether the solvent is soluble.
Surface Properties	Is Hydrophobic?	Indicate with Yes or No whether the surface is hydrophobic.

Continue to define Physico-Chemical Design and Methods.

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	Other options
	Other options

Design and Methods Field

Description

Design and Methods Description

Enter a description for the characterization design and methods.

Info

title	Extra lines add

If you include an extra line between text in the Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

Include Page

	Technique and instrument
	Technique and instrument

Technique*

Include Page

	Technique
	Technique

Abbreviation

Include Page

	Abbreviation
	Abbreviation

Description

Enter a description of the technical and instrument.

Instrument

Include Page

	Instrument
	Instrument

Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

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Include Page

	Data and conditions1
	Data and conditions1

Column Type "Datum" is selected with this characterization	Autopopulated Column Name Option[s]
Molecular Weight	Molecular Weight
Purity	% purity for sample
Relaxivity	R1, R2, T1, T2
Size	PD1, Peak N , RMS size, Z Average
Surface	charge, zeta potential

Include Page

	Data and conditions2
	Data and conditions2

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Access a sample and characterization.
Click All or the In Vitro Characterizations tab and click Add next to In Vitro Characterization. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

Anchor

	AddInVitroCharacterization
	AddInVitroCharacterization

Field/Section	What to Do
In Vitro Characterization	Fill in the general information about the characterization.
[Characterization] Properties ]	Displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Finding	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to Other Samples...	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

...

Include Page

	Other options
	Other options

Field	Description
Characterization Type*	The Characterization Type is already selected as In Vitro Characterization.
Characterization Name*	You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type. To select an existing, non-standard Assay Type, based on Characterization Type, select other_vt. To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list. Image Modified
Assay Type	The field populates automatically with options displayed for in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. With Characterization Name, other_vt, select from existing, non-standard Assay Types. With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – Version	If available, select the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
Characterization Source	Select or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization Date	Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to In Vitro Properties.

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Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.

Characterization Selection	Assay Type Corresponding to Characterization
Blood Contact	Coagulation Complement Activation Hemolysis Plasma Protein Binding Platelet Aggregation
Cytotoxicity	Caspase 3 apoptosis Cell viability Gene expression Mitochondrial function Mitochondrial membrane potential Proliferation
Immune Cell Function	CFU – GM Chemotaxis Cytokine induction Cytotoxic activity Leukocyte proliferation Oxidative Burst Phagocytosis
Oxidative stress	GSH homeostasis Lipid peroxidation ROS generation
Sterility	Bacterial/yeast/mold Endotoxin Mycoplasma
Targeting	Cell binding/Internalization
Transfection	Click [Other] to add an assay type.

Continue to define in vitro characterizations.

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Include Page

	Other options
	Other options

Design and Methods Field

Description

Design and Methods Description

Enter a description for the characterization design and methods.

Info

title	Extra lines add

If you include an extra line between text in the Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

Include Page

	Technique and instrument
	Technique and instrument

Technique*

Include Page

	Technique
	Technique

Abbreviation

Include Page

	Abbreviation
	Abbreviation

Description

Enter a description of the technique and instrument.

Instrument

Include Page

	Instrument
	Instrument

Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

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Include Page

	Data and conditions1
	Data and conditions1

- - - Column Type "Datum" is selected with this characterization Autopopulated Column Name Option[s]
      Enzyme Induction
      % of Control

Include Page

	Data and conditions2
	Data and conditions2

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Access a sample and characterization.
Click the All or In Vivo Characterizations tab and click Add next to In Vivo Characterizations. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

Field/Section	What to Do
In Vivo Characterization	Fill in the general information about the characterization.
[Characterization] Properties	Displays for in vivo characterizations.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Findings	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to Other Samples...	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

...

Include Page

	Other options
	Other options

Field

Description

Characterization Type*

The Characterization Type is already selected as In Vivo Characterization.

Characterization Name*

You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type.

Info
If you select Pharmacokinetics and Toxicity, there are no customizations on this Characterization page based on either of these selections.

To select an existing, non-standard Assay Type, based on Characterization Type, select other_vv or other_ex_vv.
To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list.
Image Modified

Assay Type

Leave this blank or select a type.

With Characterization Name, other_vv or other_ex_vv, select from existing, non-standard Assay Types.
With Characterization Name, other, create a new, non-standard Assay Type.

Protocol Name – Version

Select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.

Characterization Source

Select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).

Characterization Date

Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define In Vivo Design and Methods.

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Include Page

	Other options
	Other options

Design and Methods Field

Description

Design and Methods Description

Enter a description for the characterization design and methods.

Info

title	Adding extra lines

If you include an extra line between text in the Characterizations free text, Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

Include Page

	Technique and instrument
	Technique and instrument

Technique*

Include Page

	Technique
	Technique

Abbreviation

Include Page

	Abbreviation
	Abbreviation

Description

Enter a description of the technique and instrument.

Instrument

Include Page

	Instrument
	Instrument

Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

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