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To serve the need for research across domains, the National Cancer Institute Clinical and Translational Imaging Informatics Project (NCI CTIIP) team is developing and deploying creating a set of open source software tools that supports support a comprehensive and reusable exploration and fusion of imaging, clinical, and molecular data. The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) projects have created a rich multi-domain data set. This data set, however, is in an infrastructure that provides limited query capability for identifying cases based on all of the available data types. (For example...?)

The CTIIP team will therefore develop a unified query interface to facilitate cross-disciplinary analysis. This infrastructure make it easier to analyze data from different disciplines. This interface, plus the related software and data standards, would then be applied to clinical/co-clinical settings , using data collected for this purpose(small animal models), and provide a common platform and data engine for the hosting of “pilot challenges.” These pilot challenge projects challenges will proactively facilitate biological and clinical research across three NCI divisions. The algorithms used in the pilot challenges will be shared with the community via an open-source software clearinghouse.

The approach taken to development in this project emphasizes modular semantic interoperability and open source tooling, making it immediately valuable to scientists with NCI-funded research networks in the three research domains, as well as the national and international research communities, and providing a framework for enhanced adoption of these methods by biologists in the larger genomics/proteomic communities.

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DomainData Set
Clinical ImagingThe Cancer Genome Atlas (TCGA) clinical and molecular data
 The Cancer Imaging Archive (TCIA) in-vivo imaging data
Pre-clinicalSmall animal models
Digital PathologycaMicroscope

CTIIP is composed of three sub-projects that. The sub-projects, along with the solutions they provide, are discussed in this guide and listed below.

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