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Challenge participants receive test and training data by creating shared lists in TCIA, then pulling those into CodaLab. Once participants upload their results, they can see them in ePad.

Scenarios

Need to generate proper therapy for a patient. Look at in vivo imaging, radiology and pathology, run a gene panel to look for abnormal. Look at co-clinical trials (model of a tumor in a mouse that is similar to a human. Experiment therapies on mice.) Run an integrative query to develop a sophisticated diagnosis. Search big data.

Visual pathology integrative queries–Ashish at Emory. Imaging consistent with ground truth.

Need to explain how the challenge management system and integrative query system play together in a scientific scenario.

three tocs: one for challenge steps, one for int query sys. how well does it integrate; what are the common–how do we annotate the tumor in MedICI such that it is compatible with the annotations in the components of the integrative query system. What relationships can we find in the informatics in the animal and patient findings.

Describe each section separately and then see if we can merge the two to answer the scientific question.

Informatics help us communicate. It can help us better treat our patients.

For example, breast cancer has biomarkers (progesterone status, etc.). One question to ask is "if the estrogen status is negative in humans, what does the pathology look like?" Then compare this to mice. Is the model we have a good model for the human condition?