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Within the three research domains that CTIIP intends to make available for integrative queries, only one, clinical imaging, has made some progress in terms of establishing a framework and standards for informatics solutions. Those standards include Annotation and Image Markup (AIM), which allows researchers to standardize annotations and markup for radiology images, and Digital Imaging and Communications in Medicine (DICOM), which is a standard for handling, storing, printing, and transmitting information in medical imaging. For pre-clinical imaging and digital pathology, there are no such standards that allow for the seamless viewing, integration, and analysis of disparate data sets to produce integrated views of the data, quantitative analysis, data integration, and research or clinical decision support systems. The micro-Annotation and Image Markup (µAIM) model is currently in development to serve the unique needs of the pre-clinical domain.

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Image markups and annotations also require standards so that they can be read by different imaging disciplines along with the rest of the image data. Support for the micro-Annotation and Image Markup ( μ-AIM ) model will be added to caMicroscope so that researchers can include image annotation and markup features in digital pathology data.

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