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Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.

• Physico-chemical characterizatiPhysico-chemical characterization on refers to the characterization of physical and chemical properties of a sample.
• In vitro characterization refers to characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
• In vivo characterization refers to characterization for the nanomaterial component of the sample determined by the effect of samples on living cells.

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AccessCharacterization AccessCharacterization

Accessing Sample Characterization

To access characterization functions in the Navigation TreeIn the Navigation Tree on the left sidebar

1. Click the Characterization button. 

2. The All tab displays characterizations already added to the sample. The remaining tabs show annotations specific to those categories.

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   Based on your security privileges, you may have read-only access to existing items or the ability to Add and Delete function details.

   

3. Select Add on On the All tab for , with the appropriate security privileges, click Add next to the category of characterization annotations you want to add, such as Physico-chemical Characterization. You can also select the corresponding tab where you can add characterizations to the sample.

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The page that opens after you click an Add button to add a characterization is very similar for all characterization types. The page differs only in the Properties section if there are special properties driven by the selection of characterization names. They also differ in the drop-down values for the column name in the Finding section driven by the characterization name and assay type selections.

Follow the links below for more information about entering characterization information for the sample of interestThe following links provide additional details.

• Adding a Physico-chemical Characterization
• Adding an In Vitro Characterization
• Adding an In Vivo Characterization

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PhysicoChemical PhysicoChemical

Adding a Physico-Chemical Characterization

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Adding a Physico-Chemical Characterization

Physico-chemical characterization subcategory allows you to enter physical or chemical characterizations for the nanomaterial component of the sample.The page that opens is organized into five sections. This page is the same for all physico-chemical characterizations, except for slight .

1. Access the characterization functions.
2. Click the All or Physico-Chemical Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization Type*

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1. field.
2. The Characterization type is already selected as Physico-Chemical Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add.,
3. The [Characterization] Properties section displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable.
4. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data.
5. In the Finding section, add data findings and supporting documentation relating to the sample.
6. In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
7. In the Copy to other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.
8. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

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After adding one or more files, add data and conditions or if you have no derived data to add, add a Physico-Chemical Characterization.

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data to add, add a Physico-Chemical Characterization.

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InVitro InVitro

Adding an In Vitro Characterization

In vitro characterization After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vitro Characterizations or select the In Vitro Characterization tab where you can also click the Add button to add characterizations. The In Vitro Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.The page that opens is organized into five sections. This page is the same for all in vitro characterizations, except for slight

1. Access the characterization functions.
2. Click the All or In Vitro Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field

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1. .
2. The Characterization type is already selected as In Vitro Characterization. In the Characterization Name* field in the upper right, select from the drop-down list the name of the Characterization you want to add (required).
3. The [Characterization] Properties section displays only for Cytotoxicity, Enzyme Induction and Transfectionin vitro characterizations. Define properties for the characterization, if applicable.
4. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data.
5. In the Finding section, add data findings and supporting documentation relating to the sample. 
6. In the Analysis and Conclusions section, enter any relevant analyses and conclusions reached by the data.
7. In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.
8. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

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Adding a File

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InVivo InVivo

Adding an In Vivo Characterization

In vivo characterization After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vivo Characterizations or select the In Vivo tab where you can also click the Add button to add characterizations. The In Vivo Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.The page that opens is organized into five sections. This page is the same for all in vivo characterizations. Instructions for using the page are outlined in the steps below

1. Access the characterization functions.
2. Click the All or In Vitro Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.
3. The Characterization type is already selected as In Vivo Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add. The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.
   For more information about completing the Summary section, see Defining an In Vivo Characterization Summary.
   No [Characterization] Properties section displays for in vivo characterizations.
4. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see Defining In Vivo Design and Methods.
5. In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see Describing Findings for In Vivo Characterizations.
6. In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
7. In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see Copying Characterizations.
8. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

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Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.

• Physico-chemical
characterization refers to the
• characterization
of physical and chemical properties of a sample.
• In vitro characterization refers to characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
• In vivo characterization refers to characterization for the nanomaterial component of the sample determined by the effect of samples on living cells.

To view a sample characterizations summary

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