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PhysicoChemical PhysicoChemical

Adding a Physico-Chemical Characterization

Physico-chemical characterization allows you to enter physical or chemical characterizations for the nanomaterial component of the sampleThe following is a general path to add a physico-chemical characterization. Links are provided todetailed instructions.

1. Access the characterization functions.

2. Click the All or Physico-Chemical Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization Type* field.

   The Characterization type is already

   Field/Section	What to Do
   Characterization Type	Already selected as Physico-Chemical Characterization.

   In the

   Characterization Name

   field in the upper right, select

   *	Select from the drop-down list the name of the Characterization you want to add (required).

   ,
   The 

   [Characterization] Properties

   section displays Design

   Displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable.

   In the

   Design and Methods

   section, complete

   Complete the fields describing techniques and instruments used to derive the data.

   In the Finding section, add

   Finding

   Add data findings and supporting documentation relating to the sample.

   In the

   Analysis and

   Conclusion

   Conclusions

   Enter

   section, enter

   any relevant analyses and conclusions reached by the data.

   In the

   Copy to other Samples...

   section, select

   Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

3. When you finish, click Submit to save the data to the sample

   or click Reset to clear all fields on the form

   .

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Defining Physico-Chemical Characterization

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In vitro characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.

The following is a general path to add an in vitro characterization. Links are provided to detailed instructions.

1. Access the characterization functions.

2. Click the All or In Vitro Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

   The Characterization type is already

   Field/Section	What to Do
   Characterization Type	Already selected as In Vitro Characterization

   . In the

   Characterization Name*

   field in the upper right, select

   Select from the drop-down list the name of the Characterization you want to add (required).

   The

   For more information about completing the Summary section, see Defining an In Vivo Characterization Summary.

   [Characterization] Properties

   section displays

   Displays only for Cytotoxicity, Enzyme Induction and Transfectionin vitro characterizations. Define properties for the characterization, if applicable.

   In the

   Design and Methods

   section, complete

   Complete the fields describing techniques and instruments used to derive the data.

   In the Finding section, add

   Finding

   Add data findings and supporting documentation relating to the sample.

    
   In the

   Analysis and Conclusions

   section, enter

   Enter any relevant analyses and conclusions reached by the data.

   In the

   Copy to Other Samples...

   section, select

   Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

3. When you finish, click Submit to save the data to the sample

   or click Reset to clear all fields on the form

   .

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Defining an In Vitro Characterization

To continue defining this characterization

1. The Assay Type field populates automatically with options that display only for these in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. For details about these options, see . Select an option, if appropriate, or if there are none or if you prefer, select [Other] to name the assay type.
2. If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
3. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
4. Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
5. In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

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• For Cytotoxicity – Enter , enter the appropriate Cell Line.
• For Enzyme Induction – Enter , enter your name of choice.
• For Transfection – Enter , enter the appropriate Cell Line.

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In the Finding sections, you can add one or more publications relevant to the sample, as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.

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In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.

The following is a general path to add an in vitro characterization. Links are provided to detailed instructions.

1. Access the characterization functions.

2. Click the All or In

   Vitro

   Vivo Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

   Field/Section	What to Do
   Characterization Type	Already

   The Characterization type is already

   selected as In Vivo Characterization.

   In the

   Characterization Name

   field in the upper right, select

   *	Select from the drop-down list the name of the Characterization you want to

   add

   ad (required). The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.

   
   

   For more information about completing the Summary section, see Defining an In Vivo Characterization Summary.

   No

   [Characterization] Properties

   section displays

   Displays for in vivo characterizations.

   In the

   Design and Methods

   section,

   complete the fields describing techniques and instruments used to derive the data.

   For more information, see Defining In Vivo Design and Methods.In the Finding section,

   Findings	add data findings and supporting documentation

   relating to the sample. For more information, see Describing Findings for In Vivo Characterizations.

   relating to the sample.
   Analysis and Conclusions	Enter

   In the Analysis and Conclusion section, enter

   any relevant analyses and conclusions reached by the data.

   In the

   Copy to Other Samples...

   section, select

   Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact

   . For more information, see Copying Characterizations

   .

3. When you finish, click Submit to save the data to the sample

   or click Reset to clear all fields on the form

   .

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Defining an In Vivo Characterization Summary

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After adding one or more files, continue by Adding Data and Conditions or if you have no derived data to add, return to the steps described in Adding an In Vivo Characterization.

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CharacterizationSummary CharacterizationSummary

Viewing Characterizations Summary

Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or Physico-chemical characteristicscharacterizatics, or by data derived under in In vitro and in In vivo conditions.

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To view a sample characterizations summary

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