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- Perform a search for the sample.
- Click Edit in the search results row.
- In the Navigation Tree on the left sidebar, click the Characterizations link.
The All tab displays characterizations already added to the sample. The remaining tabs show annotations specific to those categories.
Info Based on your security privileges, you may have read-only access to existing items or the ability to Add and Delete function details.
On the All tab, with the appropriate security privileges, click Add next to the category of characterization annotations you want to add, such as Physico-chemical Characterization. You can also select the corresponding tab where you can add characterizations to the sample
. Other characterization functions available include: Add, Edit, Delete, Copy, Print, and Export.
Submitting Characterizations
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To The following is a general path to add a physico-chemical characterization. Links are provided to detailed instructions.
- Access the characterization functions.
Click the All or Physico-Chemical Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization Type* field.
Follow these steps to fill in the characterization. Links are provided for additional details.
Anchor AddPhysicoChemical AddPhysicoChemical Field/Section What to Do Characterization Type Already selected as Physico-Chemical Characterization. Characterization Name* Fill in the general information about the characterizationSelect from the drop-down list the name of the Characterization you want to add (required). [Characterization] Properties Displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable. Design and Methods Complete the fields describing techniques and instruments used to derive the data. Finding Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions Enter any relevant analyses and conclusions reached by the data. Copy to other Samples... Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. When you finish, click Submit to save the data to the sample.
Defining the Physico-Chemical Characterization
To continue defining Physico-Chemical Characterization fieldsdefine the general information about the characterization
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- The Characterization Type is already selected as Physico-Chemical Characterization.
- For the Characterization Name* select from the drop-down list the name of the Characterization you want to add (required).
- The Assay Type field populates automatically with your selection in the Characterization field.
- If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
- For Characterization Source, select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
- In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
After defining the summary, continue to add a Continue to define Physico-Chemical CharacterizationProperties.
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The [Characterization] Properties section opens only for the characterizations listed in the table below. To define properties for the characterizations, complete the fields as described in the following tableThe following table lists and describes the Properties fields.
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Characterization | Property Fields | Field Options |
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Physical State | Type | Select the appropriate type from among the following options: |
Shape Properties | Type (required) | Select from the drop-down list the appropriate shape type: |
Shape Properties | Aspect Ratio | Enter the shape aspect ratio. |
Shape Properties | Minimum,/Maximum Dimensions | Enter the minimum and maximum dimensions of the sample, as well as the units of measurement. |
Solubility Properties | Solvent | Select from the options or enter the name.
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Solubility Properties | Critical Concentration | Enter appropriate values for the critical concentration, then select the appropriate units for those values. |
Solubility Properties | Is Soluble? | Select Yes or No as to whether the solvent is soluble. |
Surface Properties | Is Hydrophobic? | Indicate with Yes or No whether the surface is hydrophobic. |
After defining the [characterization] properties, continue to add a Continue to define Physico-Chemical CharacterizationDesign and Methods.
Defining Physico-Chemical Design and Methods
In The following table lists and describes the Design and Methods sections, complete the fields as described in the following table.
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Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue to add a define Physico-Chemical CharacterizationFindings.
Describing Findings for Physico-Chemical Characterization
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To define the data and condition matrix, follow these steps.
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In vitro characterization allows you to add characterizations for the nanomaterial component of the sample derived from analytical techniques performed under in vitro conditions.
To The following is a general path to add an in vitro characterization. Links are provided to detailed instructions.
- Access the characterization functions.
Click the All or In Vitro Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.
Follow these steps to fill in the characterization. Links are provided for additional details.
Anchor AddInVitroCharacterization AddInVitroCharacterization Field/Section What to Do In Vitro Characterization Fill in the general information about the characterization. [Characterization] Propertieson] Displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable. Design and Methods Complete the fields describing techniques and instruments used to derive the data. Finding Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions Enter any relevant analyses and conclusions reached by the data. Copy to Other Samples... Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact. When you finish, click Submit to save the data to the sample.
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- The Characterization Type is already selected as In Vitro Characterization.
- For the Characterization Name* select from the drop-down list the name of the Characterization you want to add (required).
- The Assay Type populates automatically with options that display only for these in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. Select an option, if appropriate, or if there are none or if you prefer, select [Other] to name the assay type.
- If Protocol Name – Version is available, select from the drop-down list the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
- A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
- Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
In Characterization Date, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
Tip Include Page Other options Other options Continue to In Vitro Properties.
Assay Type Options for In Vitro Characterizations
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Characterization Selection | Assay Type Corresponding to Characterization |
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Blood Contact | |
Cytotoxicity | |
Immune Cell Function | |
Oxidative stress | |
Sterility | |
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Transfection | Click [Other] to add an assay type. |
Return to top of pageDefining In Vitro Characterizations
Defining In Vitro [Characterization] Properties
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- For Cytotoxicity, enter the appropriate Cell Line.
- For Enzyme Induction, enter your name of choice.
- For Transfection, enter the appropriate Cell Line.
Continue to define In Vitro Design and Methods.
Defining In Vitro Design and Methods
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Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving datawindow without saving data.
Continue to define In Vitro Findings.
Describing Findings for an In Vitro Characterization
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In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.
The following is a general path to To add an in vitro characterization. Links are provided to detailed instructions.vivo characterization
- Access the characterization functions.
Click the All or In Vivo Characterizations tab. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.
Follow these steps to fill in the characterization. Links are provided for additional details.
Anchor Defining an In Vivo Characterization Defining an In Vivo Characterization Field/Section What to Do In Vivo Characterization Fill in the general information about the characterization. [Characterization] Properties Displays for in vivo characterizations. Design and Methods Complete the fields describing techniques and instruments used to derive the data. Findings Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions Enter any relevant analyses and conclusions reached by the data. Copy to Other Samples... Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.
When you finish, click Submit to save the data to the sample.
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- The Characterization Type is already selected.
- For the Characterization Name*, select from the drop-down list the name of the Characterization you want to ad (required). The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.
- You can leave the Assay Type field blank or specify an Assay Type.
If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Tip Include Page Other options Other options Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
- In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
Defining In Vivo Design and Methods.
Defining In Vivo Design and Methods
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Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Defining In Vivo Findings.
Describing Findings for In Vivo Characterizations
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