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- Click Samples and Search Existing Samples.
- Fill in criteria, and click Search.
- Click Edit in the search results.
- The Navigation Tree appears on the left sidebar and comprises functions which you can use to add annotations to the sample.
Include Page Understanding the Navigation Tree Abrev Understanding the Navigation Tree Abrev Click Composition.
The All tab displays compositions already added to the sample by category. Additional tabs show items added to the sample for each subcategory.
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- Access a sample and composition.
Click the All or Nanomaterial Entity tab to enter data or add files pertaining to the nanomaterial component of the sample. Both tabs display five sections, but the All tab provides customizations based what you select in the Nanomaterial Entity Type* field.
Include Page Other options Other options Follow these steps to fill in the composition. Links are provided for additional details.
Anchor AddNanoMaterialEntity AddNanoMaterialEntity Section What to Do Nanomaterial Entity Type* Fill in the entity type (required) and add a Description for the entity.
[Nanomaterial] Properties Fill in the customized information according to what you selected for Nanomaterial Entity Type. Composing Elements Add information regarding the elements that compose the nanomaterial entity of the sample. File Click Add to expand the page to add one or more files whose data is relevant to the nanomaterial entity or the derivation of its data.
Copy to other Characterizations Select one or more samples in the list to which you want this composition data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact. Copy to other Samples... Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact. When you finish, click Submit to save the data to the sample.
Defining Nanomaterial Entity Properties
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After defining the particle properties, continue to define Biopolymer information.
Biopolymer
A biopolymer nanoparticle is a type of polymer that is produced by living organisms. In the context of nanotechnology, a biopolymer can also be a nanomaterial entity or a functionalizing entity.
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Continue below to define carbon nanotube information.
Carbon Nanotube
Carbon nanotubes (CNTs) are fullerene-like nanostructures that consist of graphene cylinders. The ends of the construct are closed with pentagonal-shaped rings.
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Continue below to define dendrimer information.
Dendrimer
A dendrimer is a polymeric molecule which has a highly-branched, three-dimensional architecture. Dendrimers are synthesized from monomers and new branches are added in discrete steps to form a tree-like architecture. A high level of synthetic control is achieved through iterative reactions and purification at each step to regulate the size, architecture, functionality and monodispersity of the molecules. These polymers have desirable pharmacokinetic properties and a polyvalent array of surface groups that make them potential drug delivery vesicles.
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Continue below to define Emulsion information.
Emulsion
An emulsion is a suspension of liquid within another liquid or a dispersion consisting of two or more liquid phases. In the context of caNanoLab, an emulsion nanoparticle consists of nanoparticles suspended in an emulsifying liquid.
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Continue below to define Fullerene information.
Fullerene
A fullerene is one of three known pure forms of carbon that exhibits a spherical shape with a hollow interior; named after Buckminster Fuller. The number of carbon atoms comprising fullerenes is variable; several stable spherical carbon structures containing 70 or more atoms have been documented.
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Continue below to define Liposome information.
Liposome
Liposomes are substances composed of layers of lipid that form hollow microscopic spheres within which drugs or agents could be contained for enhanced safety and efficacy. Based upon its size measured in nanometer range, a liposome can be categorized as a nanoparticle.
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Continue below to define metal particle information.
Metal Particle
A metal particle is a nanoparticle composed of electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals.
There are no unique metal particle properties to be defined. Continue below to define polymer information.
Polymer
A key feature that distinguishes polymers from other molecules is the repetition of a linked series of many identical, similar, or complementary monomers. A polymer nanoparticle is just that--a polymer measured in nanometer range.
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Continue below to define quantum pot information.
Quantum Dot
A Quantum Dot is a nanometer-sized semiconductor particle, made of cadmium selenide (CdSe), cadmium sulfide (CdS) or cadmium telluride (CdTe) with an inert polymer coating. The semiconductor material used for the core is chosen based upon the emission wavelength range being targeted: CdS for UV-blue, CdSe for the bulk of the visible spectrum, and CdTe for far red and near-infrared. The size of the particle determines the exact color of a given quantum dot. The polymer coating protects cells from cadmium toxicity but also facilitates the attachment of a variety of targeting molecules, including monoclonal antibodies directed to tumor-specific biomarkers. Because of their small size, quantum dots can function as cell- and even molecule-specific markers that will not interfere with the normal cellular functions.
There are no unique quantum dot properties to be defined. Continue to define Nanomaterial Composing Elements.
Defining Nanomaterial Composing Elements
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After defining composing elements, continue to define Add supporting documentation files.
Adding a File
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After adding one or more files, return to the steps described in Adding Nanomaterial Entity Composition Annotations.
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- Access a sample and composition.
Click the All or Functionalized Entity tab to enter data or add files pertaining to the nanomaterial component of the sample. Both tabs display five sections, but the All tab provides customizations based what you select in the Functionalized Entity Type* field.
Include Page Other options Other options Follow these steps to fill in the composition. Links are provided for additional details.
Anchor AddFunctionalizedEntity AddFunctionalizedEntity Section What to Do Functionalized Entity Type* Fill in the entity type (required).
[Functionalizing Entity] Properties Fill in the customized information according to what you selected for Functionalized Entity Type. Function Information Add information about the functionalizing elements of the sample. File Click Add to expand the page where you can add one or more files whose data is relevant to the functionalizing entity or the derivation of its data.
Copy to other samples select one or more samples in the list to which you want this composition data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact. When you finish, click Submit to save the data to the sample.
Defining a Functionalizing Entity
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Continue to define Functionalizing Entity Properties.
Defining [Functionalizing Entity type] Properties
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Continue to define Function information.
Defining Function Information
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Continue to Add files, if needed.
Adding a File
To add results in the form of supporting documents to the functionalizing entity, follow these steps:
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As appropriate, continue the process described in Adding Functionalizing Entity Composition Annotations or Adding Chemical Association Composition Annotations.
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- Once you enter the essential nanomaterial entity and functionalizing entity information under the Composition category, click the Add button corresponding to Chemical Association on the All tab or select the Chemical Association tab itself where you can click the Add button.
- The page that opens is organized into three sections. Select from the drop-down list the Association Type (required). Options include:
Description: Enter any additional information that describes the chemical association of the two elements. - In the Elements Information section, both Element boxes select the nanomaterial or functionalizing entities for which you are defining the chemical association. These have been previously defined for the sample you are annotating. For each selection you make, another drop-down list appears displaying entities relating to your previous selection. Make the appropriate selections in each.The arrow between the Element text boxes symbolizes the association between the two.
- In the File section, click Add to expand the page where you can add one or more files whose data is relevant to the nanomaterial entity or the derivation of its data.
Adding Composition Files
This section of the [Sample] Composition category allows you to add files relevant to the sample independently of the entity or chemical associations that you defined. You can add as many files as you wish.
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