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Office Word

name	CAIGScope.docx

Chair:

Luigi Ferrucci M.D., Ph.D., National Institute on Aging

Co-chairs:

Gabriela Riscuta : gabriela.riscuta@nih.govM.D., C.N.S., National Cancer Institute

Konstantin Salnikow : salnikok@mailPh.nih.govD., National Cancer Institute

Useful Links:

Click here to subscribe to CAIG listserv

National Institute on Aging: https://www.nia.nih.gov/research/labs

For information on Clinical Trials, please visit:

https://www.nia.nih.gov/research/clinical-trials

For information on the Baltimore Longitudinal Study of Aging (BLSA), please visit:

https://www.nia.nih.gov/research/labs/blsa/join-blsa

If interested in participating in a clinical trial, please contact the NIA recruitment line at 410-350-3941 or email NIAStudiesRecruitment@mail.nih.gov

NIH corner (restricted access for NIH people using their PIV card and password).

Up-coming conference

Registration

Age-Dependent Changes in Cancer Biology

October 26-27, 2020

Virtual Conference

The purpose of this conference is to increase awareness of the impact of aging, in cancer risk, with special considerations of cancer in the elderly. The invited experts will provide input regarding existing gaps in knowledge, discuss the overlap and divergent paths of cancer and aging biology, and facilitate the prioritization of the scientific areas for further research efforts.

This conference is organized in collaboration with the National Cancer Institute, the National Institute on Aging, and the National Institute of Environmental Health Sciences. This conference was originally schedule for was announced for an in-person meeting ( April 2-3, 2020 ) and it is being rescheduled to a virtual meeting but was postponed due to the ongoing COVID-19 pandemic.

Draft Agenda

Day 1, April 2October 26, 2020 2020

10:00

am - 8:30 am

Registration

8:30

am –

10:

05 am

Introduction and Overview

Gabriela Riscuta, M.D., C.N.S., NCI

10:

05 am -

10:

20 am

Opening Remarks: Ned Sharpless, M.D.,

NCI

10:

20 am -

10:

35 am

Opening Remarks: Richard Hodes, M.D.,

NCI

NIA

10:

35 am -

11:

05 am

Keynote Speaker: Luigi Ferrucci, M.D., Ph.D.

NIA9:40

, NIA/IRP

11:05 am - 11:

45 am

Session I : Understanding the Molecular Biology of Cancer in Elderly

Moderator: Max Guo

9:40-10:00

, Ph.D., NIA
11:05 am -11:25 am	Anticancer mechanisms in long-lived mammals

Vera Gorbunova (

Vera Gorbunova, Ph.D., University of Rochester

)

(DAB/NIA)

11:

25 am -

11:

45 am

Connecting cancer to aging – an evolutionary perspective

James V. Degregori

(

, Ph.D., University of Colorado

)

(DAB/NIA)

10:20-10:30

Coffee break

10:30 am - 11:50 am

10:30-10:50

10:50-11:10


11:45 am -12:05 pm	Panel Discussion
12: 05 pm - 12:25 pm	Lunch
12: 25 pm - 1:05 pm 12:25 pm-12:45 pm 12: 45 pm -1:05 pm	Session II : Cellular Senescence in Cancer and Aging Moderator: Basil Eldadah, M.D., Ph.D., NIA/ERP Mechanisms of immunosenescence and Immune response to vaccines in elderly

Nan

Nan-Ping Weng

(Laboratory

, M.D., Ph.D., Laboratory of Molecular Biology and Immunology

(LMBI), NIA

/IRP

)

Cellular senescence in aging and cancer

. Darren Backer (Majo Clinic)

11:10-11:30

The differences in response to CART-T cell therapy in young versus old persons Carl June (University of Pennsylvania)

11:30 am - 11:50 am

Panel Discussion

11:50 pm - 12:50 pm

Lunch

12:50 pm - 1:50 pm

Darren Baker, Ph.D., Mayo Clinic

1:05 pm – 1:25 pm

Panel Discussion

1:25 pm - 2:05 pm

1: 25 pm - 1: 45 pm

1:45 pm – 2:05 pm

Session III : Implication of Oxidative Stress Towards Cancer Biology

Moderator: Konstantin Salnikow,

DCB/NCI

12:50-1:10

Oxidative stress in cancer and aging Toren Finkel (Aging Institute, University of Pittsburgh)

1:10-1:30

Ph.D., NCI

Gender effects in cancer and aging

Vadim Gladyshev

(

, Ph.D., Brigham and Women’s Hospital, Harvard Medical School

)

1:30-1:50

Dysregulation of iron metabolism in cancer and aging

Suzy Torti (

Suzy Torti, Ph.D., University of Connecticut

)1:50


2:05 pm - 2:25 pm	Panel Discussion
2: 25 pm - 2:

30 pm

Coffee break

2:30 pm – 3:10 pm

2:30 pm -

00pm

50 pm

2:50 pm - 3:10 pm

Session IV :

Senescence, Immune Response and Cancer in the Elderly

Moderator

Moderators: Matt Young

and Anil Wali (DCP/NCI)

2:30-2:50

Metabolites: effects on cancer and aging Fred Stevens (Linus Pauling Institute)

, Ph.D., and Anil Wali, Ph.D., NCI

Telomere and genome integrity in cancer and aging

Patricia Opresko, Ph.D., University of Pittsburgh (NCI)

2:50-3:10

New technologies to study mitochondria-telomere cross-talk

Ben van Houte

3:10-3:30

3:30-3:50

Inter-relationship between microbiota diversity, obesity and race in endometrial cancer

Victoria Lin Bae-

Jump (University

Jump, M.D., Ph.D., University of North Carolina, Chapel Hill

)Cancer drug discovery by targeting aged tumor microenvironment Ashani Weeraratna (Johns Hopkins University) (DCTD/NCI)

10 pm -

30 pm

Panel Discussion

30 pm

–

- 4:

30 pm

Coffee Break

4:20

3: 30 pm -

50 pm

50 pm - 4:

00 Pm

4:00-4:20pm

10 pm

Session V : Environmental Factors: the Overlap of Carcinogens/Gerontogens

Moderator:

Nicole McNeil Ford and

Les Reinlib, Ph.D., NIEHS

Environmental genomics of breast and prostate cancer

Susan Neuhausen (

Susan Neuhausen, Ph.D., City of Hope

)

( NIEHS)

Breast Cancer in young & older women

;

Lead, Carolina Breast Cancer Study; co-I, African American Breast Cancer Epidemiology and Risk (AMBER); Cancer Genome Atlas Melissa Troester, UNC CH (NIEHS)

4:50 pm - 5:20 pm

10 pm - 4:

Exploring Social Networks and Social Capital for Cancer Screening among Minorities in Public Housing Jamilia Sly (Icahn School of Medicine, Mt. Sinai)

30 pm

Panel Discussion

30 pm

Day 1 Wrap-Up

Adjourn

Day 2, April 3October 27, 2020

7:30-8:00am

Registration

10:00 am -

10: 10 am

Goals and Objectives

Konstantin

Konstantin Salnikow Ph.D. NCI

10:10 am -

10:

40 am

Keynote: Epigenetic linkage of aging, cancer and nutrition

Trygve Tollefsbol

D.O.

, Ph.D., University of Alabama

8:50 am - 9

(DCP/NCI)

10:40 am - 11:50 am

10:40 am - 11:00 am

11:00 am - 11:20 am

11:20 am - 11:50 am

Session VI : Potential Impact of Nutrition on Cancer Prevention

Moderator : Pataje Prasanna Ph

Moderator: Gabriela Riscuta, M.D.,

and Gabriela Riscuta M

C.N.S., and Pat Prasanna, Ph.D., NCI

8:50-9:10

9:10-9:30

Senolytic bioactive food components and their biological pathway for action

Simmin Meydani, D.V.M., Ph.D.

Tufts University, MA

Potential Impact of bioactive food components on cancer in the aged

, Tufts University (DCP/NCI)

Cancer prevention in elderly and particularities for mechanisms of action

Chengguo Xing, Ph.D., University of Florida (DCP/NCI)

The mechanisms of fasting and advanced glycation end products in cancer prevention in elderly

Sebastian Brandhorst, Ph.D., University of Southern California

, CA

9:30-9:50

Cancer prevention in elderly and particularities for mechanisms of action Chengguo Xing Ph.D., University of Florida

(DCP/NCI)

11:50 am -12:10 pm

9:50 am -10:20 am

	Panel Discussion
12:10

:20

pm -

12:

30am

Coffee Break

30 pm	Lunch Break
12

:30 pm -

1:00 pm

Keynote speaker:

Jan Van Duersen (Mayo Clinic)

Melanoma metastasis to lymph nodes; mechanisms and contributing factors.Sean Morrison, Ph.D., UT Southwestern

1:00 pm - 2:00 pm

Session VII :

11:00 am - 12:00 am

Cancer Therapeutics and Treatment Optimization for the Elderly

Moderators: Weiwei Chen

and

, Ph.D., and Christina Liu

, Ph.D., PE, NCI

:00 pm -

1:20 pm

Improvement of cancer therapy by exploiting cellular senescence Judith Campisi (Buck Institute for Research on Aging) (

Age against the machine: How the aging microenvironment governs tumor progression and response to therapy

Ashani Weeraratna Ph.D., Johns Hopkins University (DCTD/NCI)

1:20 pm -

1:40

Targeting senescent cells using nanoparticles ΙGreg Lanza (

pm	VLA4-nanoparticles hijack cell adhesion mediated drug resistance to target refractory myeloma cells and prolong survival Greg Lanza M.D., Ph.D., Washington University at St. Louis

)

(DCTD/NCI)

1:40 pm -

2:00 pm

Treatment Optimization

and immunotherapy

for the

eldelrly with comorbidities Heidi Klepin (Wake Forest)

elderly with comorbidities

Heidi Klepin, M.D., Wake Forest School of Medicine (DCTD/

NCI)

2:00

pm -

20 pm

Panel Discussion

20 pm -

30 pm

Wrap Up and Adjourn

Planning Committee:

Luigi Ferrucci, M.D., Ph.D., (NIH/NIA/IRP) Chair

Gabriela Riscuta, M.D., C.N.S. (NIH/NCI/DCP); co-chair

Konstantin Salnikow, Ph.D., (NIH/NCI/DCB); co-chair

Nelson Aguila, D.V.M., (NIH/NCI)Audie Atienza (NIH/NIA/ERP)

Weiwei Chen, Ph.D., (NIH/NCI)

Rafael deCabo Basil Eldadah, M.D., Ph.D., (NIH/NIA/IRP)Myriam Gorospe (NIH/NIA/IRPERP)

Max Guo, Ph.D., (NIH/NIA/ERP)

Christina Liu (NIH/NCI)Nicole McNeil Ford , Ph.D., (NIH/NCI)Carmen Moten (NIH/NIA/ERP)

Pat Prasana Prasanna, Ph.D., (NIH/NCI/DCTD)

Leslie Reinlib, Ph.D., (NIH/NIEHS)Ranjan Sen (NIH/NIA/IRP)

Harold Seifried ( NIH/NCI/DCP)

Sudhir Srivastava Sudhir Srivastava, Ph.D., M.P.H., (NIH/NCI/DCP)

Anil Wali, Ph.D., (NIH/NCI)

Matthew Young, Ph.D., (NIH/NCI/DCP)

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