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  1. Access a sample and composition.

  2. Click the Nanomaterial Entity tab or the All tab and click Add next to Nanomaterial Entity.

  3. Both tabs provide customizations based on your Nanomaterial Entity Type* selection.

    Include Page
    Other options
    Other options

  4. Follow these steps to fill in the composition. Links are provided for additional details.

    Anchor
    AddNanoMaterialEntity
    AddNanoMaterialEntity


Step...What to Do..
Nanomaterial Entity Type*

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Select the entity type (required) and add a Description for the entity.

A Biopolymer nanoparticle is a type of polymer that is produced by living organisms. In the context of nanotechnology, a biopolymer can also be a nanomaterial entity or a functionalizing entity.

A Carbon Nanotube (CNTs) is a fullerene-like nanostructure that consist of graphene cylinders. The ends of the construct are closed with pentagonal-shaped rings.

Dendrimer is a polymeric molecule which has a highly-branched, three-dimensional architecture. Dendrimers are synthesized from monomers and new branches are added in discrete steps to form a tree-like architecture. A high level of synthetic control is achieved through iterative reactions and purification at each step to regulate the size, architecture, functionality and monodispersity of the molecules. These polymers have desirable pharmacokinetic properties and a polyvalent array of surface groups that make them potential drug delivery vesicles.

An Emulsion is a suspension of liquid within another liquid or a dispersion consisting of two or more liquid phases. In the context of caNanoLab, an emulsion nanoparticle consists of nanoparticles suspended in an emulsifying liquid.

A Fullerene is one of three known pure forms of carbon that exhibits a spherical shape with a hollow interior; named after Buckminster Fuller. The number of carbon atoms comprising fullerenes is variable; several stable spherical carbon structures containing 70 or more atoms have been documented.

A Liposome is a substance composed of layers of lipid that form hollow microscopic spheres within which drugs or agents could be contained for enhanced safety and efficacy. Based upon its size measured in nanometer range, a liposome can be categorized as a nanoparticle.

A Metal Particle is a nanoparticle composed of electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals.

A Quantum Dot is a nanometer-sized semiconductor particle, made of cadmium selenide (CdSe), cadmium sulfide (CdS) or cadmium telluride (CdTe) with an inert polymer coating. The semiconductor material used for the core is chosen based upon the emission wavelength range being targeted: CdS for UV-blue, CdSe for the bulk of the visible spectrum, and CdTe for far red and near-infrared. The size of the particle determines the exact color of a given quantum dot. The polymer coating protects cells from cadmium toxicity but also facilitates the attachment of a variety of targeting molecules, including monoclonal antibodies directed to tumor-specific biomarkers. Because of their small size, quantum dots can function as cell- and even molecule-specific markers that will not interfere with the normal cellular functions.

A key feature that distinguishes a Polymer from other molecules is the repetition of a linked series of many identical, similar, or complementary monomers. A polymer nanoparticle is just that--a polymer measured in nanometer range.

Note:  Entity types are described in the caNanoLab Glossary.

Nanomaterial PropertiesIf you select one of the following entity types, you need to fill in additional Properties.
  • Bipolymer
  • Carbon Nanotube
  • Dendrimer
  • Emulsion
  • Fullerene
  • Lipsome
  • Polymer

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Composing ElementsAdd information regarding the elements that compose the nanomaterial entity of the sample.
Composition File

Click Add to expand the page to add one or more files whose data is relevant to the nanomaterial entity or the derivation of its data.

Copy to other samples with the same primary organization?Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

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Defining Nanomaterial Entity Properties

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Nanomaterial Entity TypeProperties to Complete

Biopolymer

  1. Enter the Name of the biopolymer.
  2. Include Page
    Biopolymer type
    Biopolymer type
  3. Using the appropriate format, enter the complete Sequence of the biopolymer.

Carbon Nanotube

  1. Enter the Average Length of the nanotube.
  2. Enter the Length Unit of measurement for the average length measurement of the nanotube.
  3. The spatial position or orientation of functional groups located within a molecule.
    • Enter information about the Chirality in the nanotube and its effect on the orientation of functional groups located on the particle.
  4. Enter the measurement of the nanotube Diameter, as measured from one side of the tube wall through the center of the nanotube to the opposite point on the circumference.
  5. Enter the Diameter Unit of measurement for the nanotube diameter.
  6. Select the appropriate description of the nanotube Wall Type.
    • DWNT (Double-Wall Nanotube) Nanotube wall consists of two layers of graphitic carbon.
    • MWNT (Multiple-Wall Nanotube) Nanotube consists of single-walled nanotubes layered inside each other
    • SWNT (Single-wall Nanotube) Wall consists of a single layer of graphitic carbon

Dendrimer

  1. Branches are molecules that branch off of the core (like tree branches).
    • Enter a description that represents the number of Branches in the dendrimer.
  2. Generations are shells layered on the core of a dendrimer. Dendrimers consist of layers of chemical shells built on a core module. Each shell consists of two chemicals in the same order (A-B) and each shell is called a generation. The generations are labeled in decimal to illustrate the shell layering/consistency. For example, Generation 2.5 (G2.5) = 1 shell of A-B (1), surrounded by a second shell of A-B (2), topped off with only one chemical A within the shell (.5). As such, the layering structure would be (A-B, A-B, A) = 2.5.
    • List the Generations reflected in this dendrimer.

Emulsion

  1. Specify whether the composition Is Polymerized (required). Polymerization consists of enzymatic reactions that link a series of monomers, forming a polymerized compound (polymer), usually of high molecular weight, by combination of simpler molecules (monomers).
  2. Enter the name of the polymer (Polymer Name) suspended in the emulsion (required).

Fullerene

  1. Enter the Average Diameter measurement, as measured from one side of the nanoparticle through its center to the opposite point on the circumference.
  2. Enter the Average Diameter Unit of measurement for the fullerene diameter.
  3. Enter the Number of Carbon molecules comprising the fullerene.

Liposome

  1. Enter the name of the liposome polymer (Polymer Name).
  2. Polymerization consists of enzymatic reactions that link a series of monomers, forming a polymerized compound (polymer), usually of high molecular weight, by combination of simpler molecules (monomers).

    • Specify Yes or No to indicate whether the liposome Is Polymerized or not (require).

Polymer

  1. In Initiator, enter the agent that initiated the polymerization. Examples are free radicals or peroxide.
  2. Crosslinking is a covalent bond between two polymers or two different regions of the same polymer.
    • Specify Yes or No to indicate whether the polymer Is Crosslinked.
  3. In Crosslink Degree, enter the percentage level of covalent linkage in the polymer.

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Defining Nanomaterial Composing Elements

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  1. Access a sample and composition.
  2. Click the Functionalizing Entity tab or the All tab and click Add next to Functionalizing Entity.

  3. Both tabs provide customizations based on your Functionalizing Entity Type* selection.

    Include Page
    Other options
    Other options

  4. Follow these steps to fill in the composition. Links are provided for additional details.

    Anchor
    AddFunctionalizedEntity
    AddFunctionalizedEntity

Step...Description...
Functionalizing Entity

Select the Entity Type and

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complete the entity information.

Note:  Entity types are described in the caNanoLab Glossary.

Functionalizing Entity Properties

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If you selected one of the following entity types, you

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need to fill in additional

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properties.
  • Antibody
  • Bipolymer
  • Small Molecule
Inherent Function InformationAdd information about the functionalizing elements of the sample.
Composition File

Add one or more files containing data that is relevant to the functionalizing entity or the derivation of its data.

Copy to other samples with the same primary organization?Select one or more samples in the list to which you want this composition data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

Return to top

Defining a Functionalizing Entity

Fill in the following functionalized entity information as needed.

Complete...How to...
Entity Type

Select the functionalizing entity type.

Note:  Entity types are described in the caNanoLab Glossary.

Chemical NameEnter the chemical name for the functionalizing entity whose type you just selected.
PubChem Data Source/PubChem ID

Include Page
PubChem data source
PubChem data source

Amount/Amount Unit

Include Page
Amount unit
Amount unit

Molecular Formula Type

Include Page
Molecular formula type
Molecular formula type

Molecular FormulaEnter the chemical formula of the functionalizing entity.
Activation Method

Select the method used to activate the functionality of the sample from the list.

Info
If you do not have to activate the entity, select does not require activation.
Activation EffectEnter the functional effect of the entity.
DescriptionEnter any additional composition information that the form does not include.

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For Entity TypeComplete the Properties...
Antibody
  1. Select the Type of antibody functioning for this sample.
  2. Select the Isotype for this antibody.
  3. Select the animal Species from which the antibody was derived.
Biopolymer
  1. Include Page
    Biopolymer type
    Biopolymer type
  2. Using the appropriate format, enter the complete Sequence of the biopolymer.
Small MoleculeAdd an Alternate Name for the Small Molecule.

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Info
titleChemical association requirement

To enter chemical association information, you must enter at least two composing elements and/or at lease least one functionalizing entity to the sampe sample entity.

To add a chemical association

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