Page History

10:00 am

– 10:05 am

 Introduction and Overview

Gabriela Riscuta

NCI/DCP

10:

05 am -

10:

20 am

Opening Remarks: Ned Sharpless

NCI

10:

20 am -

10:

35 am

Opening Remarks: Richard Hodes

NIA

10:35 am -11:05 am

Keynote Speaker: Luigi Ferrucci,

NIA

11:

05 am - 11:

45 am

Understanding the Molecular Biology of Cancer in Elderly

Moderator: Max Guo NIA

11:

05 am -

11:

25 am

Anticancer mechanisms in long-lived mammals   Vera Gorbunova (University of Rochester) (DAB/NIA)

11:

25 am -

11:

45 am

Connecting cancer to aging – an evolutionary perspective James V. Degregori (University of Colorado) (DAB/NIA)

11:

45 am -

12:

05 pm

Panel Discussion

12: 05 pm - 12: 25 pm

Lunch

12: 25 pm - 1:10 pm

12:25 pm-12:45 pm

12: 45 pm -1: 05 pm

Cellular Senescence in Cancer and Aging

Moderator: Basil Eldadah, NIA

Mechanisms of immunosenescence and Immune response to vaccines in elderly  Nan-Ping Weng (Laboratory of Molecular Biology and Immunology, LMBI, NIA-IRP)

Cellular senescence in aging and cancer. Darren Backer (Majo Clinic)

1: 05 pm – 1:25 pm

Panel Discussion

1:25 pm - 2:10 pm

Implication of Oxidative Stress Towards Cancer Biology

Moderator: Konstantin Salnikow, DCB/NCI

1: 25 pm - 1:

45 pm

Gender effects in cancer and aging  Vadim Gladyshev (Brigham and Women’s Hospital, Harvard Medical School)

1:

45 pm – 2:05 pm

Dysregulation of iron metabolism in cancer and aging  Suzy Torti (University of Connecticut)

2:05 pm - 2:25 pm

Panel Discussion

2: 25pm - 2:

30 pm

Coffee break

2:30 pm – 3:10 pm

Senescence, Immune Response and Cancer in the Elderly

Moderators: Matt Young and Anil Wali

, NCI

3:

10pm -

3:

30 pm

Panel Discussion

3:

30 pm

- 4:

30 pm

3: 30- 3:50 Pm

3:50- 4:10pm

Environmental Factors: the Overlap of Carcinogens/Gerontogens

Moderator:

Les Reinlib  NIEHS

Environmental genomics of breast and prostate cancer  Susan Neuhausen (City of Hope) ( NIEHS)

Breast Cancer in young & older women; Lead, Carolina Breast Cancer Study; co-I, African American Breast Cancer Epidemiology and Risk (AMBER); Cancer Genome Atlas Melissa Troester, UNC CH (NIEHS)

10:00 am -

10: 10 am

Goals and Objectives

10:10 am -

10:

40 am

Keynote: Epigenetic linkage of aging, cancer and nutrition

Trygve Tollefsbol

(University of Alabama

) (DCP/NCI)

10:40 am -

11:50 am

Potential Impact of Nutrition on Cancer Prevention

Moderator :

Gabriela Riscuta and Pat Prasana

10:40 am -11:00 am

Senolytic bioactive food components and their biological pathway for action  Simmin Meydani (Tufts University)  (DCP/NCI)

11:00-11:20 am

Cancer prevention in elderly and particularities for mechanisms of action  Chengguo Xing  (University of Florida) (DCP/NCI)

11:20 am - 11:50 am

The mechanisms of fasting and advanced glycation end products in cancer prevention in elderly Sebastian Brandhorst

(UCLA) (DCP/NCI)

11:50 am -12:10

am

Panel Discussion

12:10

-

12:

30 pm

Lunch  Break

12

:30 pm -

1:00 pm

Keynote speaker:  Jan Van Duersen (Mayo Clinic)

1:00

pm -

2:00

pm

Cancer Therapeutics and Treatment Optimization for the Elderly

Moderators: Weiwei Chen and Christina Liu

1:00 pm-

1:20 pm

Improvement of cancer therapy by exploiting cellular senescence  Judith Campisi  (Buck Institute for Research on Aging) (DCTD/NCI)  

1:20 pm -

1:40

pm

The development of AI-enhanced cardiac MRI to address cardiotoxicity in elderly Multiple Myeloma patients Greg Lanza (Washington University at St. Louis) ( NCI/DCTD

)

1:40 pm -

2:00 pm

Treatment Optimization

for the

elderly with comorbidities

Heidi Klepin

(Wake Forest) (NCI/DCTD

)

2:00

pm -

2:

20 pm

Panel Discussion

2:

20-

2:

30 pm

Wrap Up and Adjourn