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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
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NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117125,000 out of the 154178,946 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (2223.05e11D: May 2022November 2023)

Image AddedImage Removed

NCIt concepts with tagged synonyms from each outside source (2223.05e11D: May 2022November 2023)

NCIt Concepts

Source

3ACC
7161182ACC/AHA
20172016

BRIDG

408CareLex
56CBDD
268

CCPS

2494727578CDISC
787794CDISC-GLOSS
21962409Cellosaurus
36603655CPTAC
406CRCH
8924CTCAE
280CTDC
426427CTEP
2601427941CTRP
636DIPG/DMG
10431069EDQM-HC
2708527959FDA
239GAIA
589012046GDC
1422HemOnc
127HL7
106ICD-10
663664ICDC
216ICH
215INC
5661mCode
1281MedDRA
23NAACCR
243245NCCN
510NCPDP
6NDC
4784NICHD
826OORO
7138ORCHESTRA
18621863PCDC
40PI-RADS
377SEER
299662SeroNet
237UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (202105202302: May 20212023)

NCIm concepts

Source Label - NCIt-derived

Source Name

7131177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 20212023_01D01E
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 20212023_01D01E
27BRIDGBiomedical Research Integrated Domain Group Model, 20212023_01D01E
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 20212023_01D01E
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 20212023_01D01E
1797418643caDSRCancer Data Standards Registry and Repository, 20212023_01D01E
407CARELEXContent Archive Resource Exchange Lexicon, 20212023_01D01E
53CBDDChemical Biology and Drug Development Vocabulary, 20212023_01D01E
265CCPSChildhood Cancer Predisposition Study, 20222023_01E
923CDCU.S. Centers for Disease Control and Prevention, 20212023_01D01E
2612028026CDISCClinical Data Interchange Standards Consortium, 20212023_01D01E
788795CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 20212023_01D01E

21672296

CELLOSAURUSCellosaurus, 20212023_01D01E
36883685CPTACClinical Proteomic Tumor Analysis Consortium, 20212023_01D01E
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 20212023_01D01E
775CTCAECommon Terminology Criteria for Adverse Events, 20212023_01D01E
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 20212023_01D01E
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 20212023_01D01E
276CTDCClinical Trial Data Commons, 2021_01D318CTEPCancer Therapy Evaluation Program, 20042023_01E
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 20212023_01D01E
2558227053CTRPClinical Trials Reporting Program, 20212023_01D01E
903904DCPNCI Division of Cancer Prevention Program, 20212023_01D01E
114DICOMDigital Imaging Communications in Medicine, 20212023_01D01E
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 20222023_01E
694695DTPNCI Developmental Therapeutics Program, 20212023_01D01E
10411050EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 20212023_01D01E
2599426703FDAU.S. Food and Drug Administration, 20212023_01D01E
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 20212023_01D01E
54725591GDCNCI Genomic Data Commons, 20212023_01D01E
281GENCGeopolitical Entities, Names, and Codes Standard, 20212023_01D01E
106ICD-10International Classification of Diseases, 10th Edition, 20222023_01E
671693ICDCNCI Integrated Canine Data Commons, 20212023_01D01E
215ICHInternational Conference on Harmonization, 20212023_01D01E
215INCInternational Neonatal Consortium, 20212023_01D01E
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 20212023_01D01E
244KEGGKEGG Pathway Database, 20212023_01D01E
166401173066NCINational Cancer Institute Thesaurus, 20212023_01D01E
5078NCI-GLOSSNCI Dictionary of Cancer Terms, 20212023_01D01E
53925659NCI-HGNCNCI HUGO Gene Nomenclature Committee, 20212023_01D01E
129NCI-HL7NCI Health Level 7, 20212023_01D01E
509NCPDPNational Council for Prescription Drug Programs, 20212023_01D01E
5NDCNational Drug Code, 20212023_01D01E
4782NICHDNational Institute of Child Health and Human Development, 2021_01D2023_01E
37ORCHESTRAORCHESTRA, 2023_01E
18321200PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 20212023_01D01E
296658SeroNetSerological Sciences Network Terminology, 20222023_01E
14561496UCUMUnified Code for Units of Measure, 20212023_01D01E
2040WHOWorld Health Organization (WHO) Terminology, 20222023_01E
25ZFINZebrafish Model Organism Database, 20212023_01D01E

NCIm concepts

Source Label - Other

Source Name

15882
15884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13257CBOClinical Bioinformatics Ontology, 2011_02
541CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2021
356CCSR_ICD10PCSClinical Classifications Software Refined for ICD-10-PCS, 2021
962CDCRECRace & Ethnicity - CDC, 1.2
3078
3079COSTARCOSTAR, 1989-1995
16494
16495CSPCRISP Thesaurus, 2006
3843
3840CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
529
562CVXVaccines Administered, 2017_02_08,
2020
2022_
07
06_
28
23
9620
9795DRUGBANKDrugBank, 5.0_2016_06_22, 5.0_
2020
2022_
07
08_
30
01
7289
7288DXPDXplain, 1994
102562
102563FMAFoundational Model of Anatomy Ontology, 4_15
7495
7485GARDGenetic and Rare Diseases Information Center, 2015_04
71208
71529GOGene Ontology,
2020
2022_05_
02
16
7591
7836HCPCSHealthcare Common Procedure Coding System,
2020
2022
42505
43131HGNCHUGO Gene Nomenclature Committee,
2020
2022_
05
04
9061
9068HL7V3.0HL7 Vocabulary Version 3.0,
2019
2021_12
17747
18309HPOHuman Phenotype Ontology,
2020
2022_06_
08
11
17424
17423ICD10ICD10, 2016
103391
104884ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2021
2023
190986
191276ICD10PCSICD-10-PCS,
2021
2023
20937ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2874
2868ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
167298
172335LNCLOINC,
268
273
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
59238
60491MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA),
23
25_1
3431
3475MED-RTMedication Reference Terminology,
2020
2022_09_
08
06
2109
2110MEDLINEPLUSMedlinePlus Health Topics,
20191029
2021_10_23
900MGEDMGED Ontology, 131
449367
451526MSHMedical Subject Headings,
2021
2023_
2020
2022_07_
16
27
212203
217126MTHUMLS Metathesaurus,
2020AB
2022AB
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2014
19009
19008MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
69394
71639MTHSPLMetathesaurus FDA Structured Product Labels,
2020
2022_08_
28
26
84
87MVXManufacturers of Vaccines,
2020
2022_09_
04
06
1983453
2062306NCBINCBI Taxonomy,
2020
2022_
05
04_
21
29
7984
8699NCIMTHNCIMTH
0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
97276
100815OMIMOnline Mendelian Inheritance in Man,
2020
2022_07_
27
25
12398PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
260
270PNDSPerioperative Nursing Data Set,
4_2018
2021
940QMRQuick Medical Reference (QMR), 1996
45834
45832RADLEXRadLex, 4_1
198630
201229RXNORMRxNorm Vocabulary, 20AA_
200908F
220906F
349474
356057SNOMEDCT_USUS Edition of SNOMED CT, 2020_09_01
167SOPSource of Payment Typology, 9.2
4810
4811SPNStandard Product Nomenclature, 2003
222
224SRCMetathesaurus Source Terminology Names
28738
28915UMDUMDNS: product category thesaurus,
2020
2022
4978
5005USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines, 2020
61112UWDAUniversity of Washington Digital Anatomist, 1.7.3
35585
37499VANDFVeterans Health Administration National Drug File, 2020_08_03

Overall Counts (May 20212023)

ConceptsRelationships Attributes Total Number of Terms
34,894002,448414

2526,315481,538435

 28 29,523294,670274 8,643917,581525