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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 125,000 out of the 178,080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (2324.04D02D: April 2023February 2024)

Image AddedImage Removed

NCIt concepts with tagged synonyms from each outside source (2324.04D02D: April 2023February 2024)

NCIt Concepts

Source

3ACC
1182ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

2684027790CDISC
794799CDISC-GLOSS
23162413Cellosaurus
36593654CPTAC
406CRCH
8924CTCAE
280CTDC
425427CTEP
2722528210CTRP
636DIPG/DMG
10531072EDQM-HC
2770928444FDA
239GAIA
608312266GDC
1466HemOnc
127HL7
106ICD-10
663664ICDC
216ICH
215INC
56615660mCode
1281MedDRA
23NAACCR
245246NCCN
510NCPDP
6NDC
4784NICHD
827826OORO
3871ORCHESTRA
1863PCDC
40PI-RADS
377SEER
661662SeroNet
237UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (202302202402: May 2023February 2024)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_01E12D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2023_01E12D
27BRIDGBiomedical Research Integrated Domain Group Model, 2023_01E12D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2023_01E12D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2023_01E12D
1864319304caDSRCancer Data Standards Registry and Repository, 2023_01E12D
407CARELEXContent Archive Resource Exchange Lexicon, 2023_01E12D
53CBDDChemical Biology and Drug Development Vocabulary, 2023_01E12D
265CCPSChildhood Cancer Predisposition Study, 2023_01E12D
923922CDCU.S. Centers for Disease Control and Prevention, 2023_01E12D
2802629019CDISCClinical Data Interchange Standards Consortium, 2023_01E12D
795800CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 2023_01E12D

22962425

CELLOSAURUSCellosaurus, 2023_01E12D
36853680CPTACClinical Proteomic Tumor Analysis Consortium, 2023_01E12D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2023_01E12D
775CTCAECommon Terminology Criteria for Adverse Events, 2023_01E12D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2023_01E12D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 2023_01E12D
276CTDCClinical Trial Data Commons, 2023_01E12D
373372CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2023_01E12D
2705328023CTRPClinical Trials Reporting Program, 2023_01E12D
904DCPNCI Division of Cancer Prevention Program, 2023_01E12D
114DICOMDigital Imaging Communications in Medicine, 2023_01E12D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_01E12D
695694DTPNCI Developmental Therapeutics Program, 2023_01E12D
10501070EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_01E12D
2670327355FDAU.S. Food and Drug Administration, 2023_01E12D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_01E12D
55916030GDCNCI Genomic Data Commons, 2023_01E12D
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_12D
1439HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2023_01E12D
106ICD-10International Classification of Diseases, 10th Edition, 2023_01E12D
693ICDCNCI Integrated Canine Data Commons, 2023_01E12D
215ICHInternational Conference on Harmonization, 2023_01E12D
215INCInternational Neonatal Consortium, 2023_01E12D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2023_01E12D
244KEGGKEGG Pathway Database, 2023_12D
5660mCodeMinimal Common Oncology Data Elements, 2023_01E12D
173066183778NCINational Cancer Institute Thesaurus, 2023_01E12D
50785079NCI-GLOSSNCI Dictionary of Cancer Terms, 2023_01E12D
56595860NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_01E12D
129NCI-HL7NCI Health Level 7, 2023_01E12D
509NCPDPNational Council for Prescription Drug Programs, 2023_01E12D
5NDCNational Drug Code, 2023_01E12D
47824780NICHDNational Institute of Child Health and Human Development, 2023_12D
825OOROOperational Ontology for Radiation Oncology, 2023_01E12D
3770ORCHESTRAORCHESTRA, 2023_01E12D
1832PCDCPediatric Cancer Data Commons, 20212023_01D12D
39PI-RADSProstate Imaging Reporting and Data System, 20212023_01D12D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 20212023_01D12D
310RENIRegistry Nomenclature Information System, 2023_01E12D
658659SeroNetSerological Sciences Network Terminology, 2023_12D
236UBERONUBERON Ontology, 2023_01E12D
14961546UCUMUnified Code for Units of Measure, 2023_01E12D
4077WHOWorld Health Organization (WHO) Terminology, 2023_01E12D
25ZFINZebrafish Model Organism Database, 2023_01E12D

NCIm concepts

Source Label - Other

Source Name

1588215884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13257CBOClinical Bioinformatics Ontology, 2011_02
541544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 20212023
356357CCSR_ICD10PCSClinical Classifications Software Refined for ICD-10-PCS, 20212023
962CDCRECRace & Ethnicity - CDC, 1.2
30783080COSTARCOSTAR, 1989-1995
1649416485CSPCRISP Thesaurus, 2006
38433839CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
529618CVXVaccines Administered, 2017_02_08, 20202023_0708_2816
962011414DRUGBANKDrugBank, 5.0_20162023_06_22, 5.0_2020_07_3008_11
72907289DXPDXplain, 1994
102562102551FMAFoundational Model of Anatomy Ontology, 4_15
74957482GARDGenetic and Rare Diseases Information Center, 2015_04
7152971881GOGene Ontology, 20222023_05_1610
78368081HCPCSHealthcare Common Procedure Coding System, 20222023
4313143627HGNCHUGO Gene Nomenclature Committee, 20222023_04
90689078HL7V3.0HL7 Vocabulary Version 3.0, 20212023_1202
1830919235HPOHuman Phenotype Ontology, 20222023_0607_1121
1742317416ICD10ICD10, 2016
104884105376ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification, 20232024
191276191545ICD10PCSICD-10-PCS, 20232024
2093720886ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
28682864ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
172335175623LNCLOINC, 273276
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
6049162093MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA), 2526_1
34753523MED-RTMedication Reference Terminology, 20222023_09_0605
21102123MEDLINEPLUSMedlinePlus Health Topics, 2021102320221101
900MGEDMGED Ontology, 131
451526456461MSHMedical Subject Headings, 2024_2023_202208_07_2703
217126218961MTHUMLS Metathesaurus, 2022AB2023AB
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_20142020
1900819007MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
7163957391MTHSPLMetathesaurus FDA Structured Product Labels, 20222023_08_2624
8788MVXManufacturers of Vaccines, 20222023_09_06
2062306719490NCBINCBI Taxonomy, 20222023_04_2913
86999532NCIMTHNCIMTH0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
100815103963OMIMOnline Mendelian Inheritance in Man, 20222023_0708_2510
1239812399PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
270PNDSPerioperative Nursing Data Set, 2021
940QMRQuick Medical Reference (QMR), 1996
4583245826RADLEXRadLex, 4_1
201229217864RXNORMRxNorm Vocabulary, 20AA_220906F230905F
356057361058SNOMEDCT_USUS Edition of SNOMED CT, 20202023_09_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
224230SRCMetathesaurus Source Terminology Names
2891529104UMDUMDNS: product category thesaurus, 20202023
50055002USPUSP Compendial Nomenclature, 20202023_0208_0617
1605USPMGUSP Medicare Model Guidelines, 2020
6111261107UWDAUniversity of Washington Digital Anatomist, 1.7.3
3749938334VANDFVeterans Health Administration National Drug File, 20202023_0807_0331

Overall Counts (May August 2023)

ConceptsRelationships Attributes Total Number of Terms
42,002684,414035

2623,481500,435918

 29 24,294395,274137 8 7,917098,525885