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Multiexcerpt
MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 45125,000 out of the 100178,000 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1124.09d02D: September 2011February 2024) chart showing NCIt concepts with terms from tagged outside sourcesImage Removed

Image Added

NCIt concepts with tagged synonyms from each outside source (1324.03d02D: March 2013February 2024)

NCIt Concepts

Source

3ACC
335
1182

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

25
ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

27790CDISC
799CDISC-GLOSS
2413Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
427CTEP
28210CTRP
636DIPG/DMG
1072EDQM-HC
28444FDA
239GAIA
12266GDC
1466HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5660mCode
1281MedDRA
23NAACCR
246NCCN
510NCPDP
6NDC
4784NICHD
826OORO
71ORCHESTRA
1863PCDC
40PI-RADS
377SEER
662SeroNet
237UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201105202402: May 2011February 2024)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_12D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use,
1105E
1,139
2023_12D
27BRIDGBiomedical Research Integrated Domain Group Model, 2023_12D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2023_12D
1658BRIDG_5_3
BRIDG
Biomedical Research Integrated Domain Group Model
, 1105E921
, 5.3, 2023_12D
19304caDSRCancer Data Standards Registry and Repository, 2023_12D
407CARELEXContent Archive Resource Exchange Lexicon, 2023_12D
53CBDDChemical Biology and Drug Development Vocabulary, 2023_12D
265CCPSChildhood Cancer Predisposition Study, 2023_12D
922CDCU.S. Centers for Disease Control and Prevention,
1105E
5,636
2023_12D
29019CDISCClinical Data Interchange Standards Consortium, 2023_12D
800CDISC-GLOSS
CDISC
Clinical Data Interchange Standards Consortium
, 1105E
Glossary Terms, 2023_12D

2425

CELLOSAURUSCellosaurus, 2023_12D
3680CPTACClinical Proteomic Tumor Analysis Consortium, 2023_12D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2023_12D
775CTCAECommon Terminology
, 1105E
6,368
Criteria for Adverse Events, 2023_12D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2023_12D
4022CTCAE_5
CTCAE
Common Terminology Criteria for Adverse Events
, 1105E903
5.0, 2023_12D
276CTDCClinical Trial Data Commons, 2023_12D
372CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2023_12D
28023CTRPClinical Trials Reporting Program, 2023_12D
904DCPNCI Division of Cancer Prevention Program,
1105E
2023_12D
114DICOMDigital Imaging Communications in Medicine
, 1105E
, 2023_12D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_12D
694
693
DTPNCI Developmental Therapeutics Program,
1105E15,471
2023_12D
1070EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_12D
27355FDAU.S. Food and Drug Administration
, 1105E
, 2023_12D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_12D
6030GDCNCI Genomic Data Commons, 2023_12D
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_12D
1439HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2023_12D
106ICD-10International Classification of Diseases, 10th Edition, 2023_12D
693ICDCNCI Integrated Canine Data Commons, 2023_12D
215ICHInternational Conference on Harmonization,
1105E
2023_12D
215INCInternational Neonatal Consortium, 2023_12D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use,
1105E
2023_12D
244KEGGKEGG Pathway Database,
1105E85,314
2023_12D
5660mCodeMinimal Common Oncology Data Elements, 2023_12D
183778NCINational Cancer Institute Thesaurus,
2011
2023_
05E
12D
5,084
5079NCI-GLOSSNCI Dictionary of Cancer Terms,
1105E125
2023_12D
5860NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_12D
129NCI-HL7NCI Health Level 7,
1105E
2023_12D
514
509NCPDPNational Council for Prescription Drug Programs,
1105E715
2023_12D
5NDCNational Drug Code, 2023_12D
4780NICHDNational Institute of Child Health and Human Development
, 1105E
, 2023_12D
825OOROOperational Ontology for Radiation Oncology, 2023_12D
70ORCHESTRAORCHESTRA, 2023_12D
1832PCDCPediatric Cancer Data Commons, 2023_12D
39PI-RADSProstate Imaging Reporting and Data System, 2023_12D
169PIDNational Cancer Institute Nature Pathway Interaction Database,
1105E
2023_12D
310RENIRegistry Nomenclature Information System
, 1105E287
, 2023_12D
659SeroNetSerological Sciences Network Terminology, 2023_12D
236UBERONUBERON Ontology, 2023_12D
1546UCUMUnified Code for Units of Measure,
1105E
2023_12D
77WHOWorld Health Organization (WHO) Terminology, 2023_12D
25ZFINZebrafish Model Organism Database,
1105E
2023_12D

NCIm concepts

Source Label - Other

Source Name

15,870
15884AODAlcohol and Other Drug Thesaurus, 2000
278
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
1,104
CCS
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2023
357CCSR_ICD10PCSClinical Classifications Software
, 20053,073
Refined for ICD-10-PCS, 2023
962CDCRECRace & Ethnicity - CDC, 1.2
3080COSTARCOSTAR, 1989-1995
16,572
16485CSPCRISP Thesaurus, 2006
3,836
3839CSTCOSTART, 1995
345
318CTEPCancer Therapy Evaluation Program, 2004
7,278
618CVXVaccines Administered, 2017_02_08, 2023_08_16
11414DRUGBANKDrugBank, 5.0_2023_08_11
7290DXPDXplain, 1994
77,923
102551FMAFoundational Model of Anatomy Ontology,
2_054,439
4_15
7482GARDGenetic and Rare Diseases Information Center, 2015_04
71881GOGene Ontology,
2010
2023_
04
05_
01
10
5,602
8081HCPCSHealthcare Common Procedure Coding System,
20107,483
2023
43627HGNCHUGO Gene Nomenclature Committee, 2023_04
9078HL7V3.0HL7 Vocabulary Version 3.0,
2006
2023_
05
02
29,335
19235

HUGO

HUGO Gene Nomenclature, 2010_05

HPOHuman Phenotype Ontology, 2023_07_21
17416
11,532
ICD10ICD10,
1998
1,004

ICD10AE

ICD10, American English Equivalents, 1998

97,631
2016
105376ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2010_03181,116
2024
191545ICD10PCSICD-10-PCS,
2009
2024
20,779
20886ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification,
2011
2014
2,466
2864ICDOInternational Classification of
Diseases
Disease for Oncology,
3rd Edition, 2000
3_2
748ICPCInternational Classification of Primary Care, 1993
37,923

ICPC2ICD10ENG

ICPC2 - ICD10 Thesaurus, 200412

80,206

LNC

Logical Observation Identifier Names and Codes, 232
5055ISO3166-2International Organization for Standardization 3166-2, 2012
175623LNCLOINC, 276
41MCMMcMaster University Epidemiology Terms, 1992
331
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
47,210
62093MDRMedical Dictionary for Regulatory Activities Terminology
, 14.01,897
(MedDRA), 26_1
3523MED-RTMedication Reference Terminology, 2023_09_05
2123MEDLINEPLUSMedlinePlus Health Topics,
20080614
20221101
900MGEDMGED Ontology, 131
310,485
456461MSHMedical Subject Headings,
2011
2024_
2010
2023_08_
30
03
85,138
218961MTHUMLS Metathesaurus,
2010AB
2023AB
19,880
11
MTHFDA
MTHCMSFRFMetathesaurus
FDA National Drug Code Directory, 2010_08_02
CMS Formulary Reference File, MTHCMSFRF_2020
19007
337

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2010

16,081
MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms,
2011
94

MTHICPC2ICD107B

ICPC2 - ICD10 Thesaurus, 7-bit Equivalents, 0412

76

MTHICPC2ICD10AE

ICPC2 - ICD10 Thesaurus, American English Equivalents, 0412

1,633
2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
12,969
57391MTHSPLMetathesaurus FDA Structured Product Labels,
2010
2023_08_
27478,187
24
88MVXManufacturers of Vaccines, 2023_09_06
719490NCBINCBI Taxonomy,
2010
2023_04_
29
13
135
9532NCIMTH

NCI Metathesaurus

38,863

NDFRT

National Drug File, 2010_09_07

1,781
NCIMTH
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research,
2010
2011_
10
12_
31
08
63,924
103963OMIMOnline Mendelian Inheritance in Man,
2010
2023_
04
08_
08
10
9,869
12399PDQPhysician Data Query,
2010
2016_
08
07_
06
31
2,041
2039PMAPortfolio Management Application, 2010
268
270PNDSPerioperative Nursing Data Set,
2nd edition, 2002
2021
940QMRQuick Medical Reference (QMR), 1996
30,033
45826RADLEXRadLex,
3
4_
33
1
227,498
217864RXNORMRxNorm Vocabulary,
10AA
20AA_
100907F
230905F
281,843
361058SNOMEDCT_US

SNOMED Clinical Terms

4,808
US Edition of SNOMED CT, 2023_09_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
156
230SRCMetathesaurus Source Terminology Names
13,788
29104UMDUMDNS: product category thesaurus,
20101,765
2023
5002USPUSP Compendial Nomenclature, 2023_08_17
1605USPMGUSP Medicare Model Guidelines,
2004
2020
61,191
61107UWDAUniversity of Washington Digital Anatomist, 1.7.3
26,546
38334VANDFVeterans Health Administration National Drug File,
2010
2023_07_
26
Wiki Markup
31

Overall Counts (August 2023)

ConceptsRelationships Attributes Total Number of Terms
2,684,035

23,500,918

 24,395,137 7,098,885
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