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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 45125,000 out of the 100178,000 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1123.09d11D: September 2011November 2023) chart showing NCIt concepts with terms from tagged outside sourcesImage Removed

Image Added

NCIt concepts with tagged synonyms from each outside source (1323.03d11D: March 2013November 2023)

NCIt Concepts

Source

3
335

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

ACC
1182ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

27578CDISC
794CDISC-GLOSS
2409Cellosaurus
3655CPTAC
406CRCH
8924CTCAE
280CTDC
427CTEP
27941CTRP
636DIPG/DMG
1069EDQM-HC
27959FDA
239GAIA
12046GDC
1422HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5661mCode
1281MedDRA
23NAACCR
245NCCN
510NCPDP
6NDC
4784NICHD
826OORO
71ORCHESTRA
1863PCDC
40PI-RADS
377SEER
662SeroNet
237UBERON
284UCUM
25
ZFin

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201105202302: May 20112023)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_01E
334BioCBioCarta online maps of molecular pathways, adapted for NCI use
, 1105E
1,139
, 2023_01E
27BRIDGBiomedical Research Integrated Domain Group Model, 2023_01E
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2023_01E
1658BRIDG_5_3
BRIDG
Biomedical Research Integrated Domain Group Model
, 1105E921
, 5.3, 2023_01E
18643caDSRCancer Data Standards Registry and Repository, 2023_01E
407CARELEXContent Archive Resource Exchange Lexicon, 2023_01E
53CBDDChemical Biology and Drug Development Vocabulary, 2023_01E
265CCPSChildhood Cancer Predisposition Study, 2023_01E
923CDCU.S. Centers for Disease Control and Prevention,
1105E
5,636
2023_01E
28026CDISCClinical Data Interchange Standards Consortium, 2023_01E
795CDISC-GLOSS
CDISC
Clinical Data Interchange Standards Consortium
, 1105E
Glossary Terms, 2023_01E

2296

CELLOSAURUSCellosaurus, 2023_01E
3685CPTACClinical Proteomic Tumor Analysis Consortium, 2023_01E
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2023_01E
775CTCAECommon Terminology
, 1105E
6,368
Criteria for Adverse Events, 2023_01E
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2023_01E
4022CTCAE_5
CTCAE
Common Terminology Criteria for Adverse Events
, 1105E903
5.0, 2023_01E
276CTDCClinical Trial Data Commons, 2023_01E
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2023_01E
27053CTRPClinical Trials Reporting Program, 2023_01E
904DCPNCI Division of Cancer Prevention Program,
1105E
2023_01E
114DICOMDigital Imaging Communications in Medicine
, 1105E
, 2023_01E
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_01E
695
693
DTPNCI Developmental Therapeutics Program,
1105E15,471
2023_01E
1050EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_01E
26703FDAU.S. Food and Drug Administration,
1105E
2023_01E
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_01E
5591GDCNCI Genomic Data Commons, 2023_01E
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_01E
106ICD-10International Classification of Diseases, 10th Edition, 2023_01E
693ICDCNCI Integrated Canine Data Commons, 2023_01E
215ICHInternational Conference on Harmonization,
1105E
2023_01E
215INCInternational Neonatal Consortium, 2023_01E
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use,
1105E
2023_01E
244KEGGKEGG Pathway Database,
1105E85,314
2023_01E
173066NCINational Cancer Institute Thesaurus,
2011
2023_
05E
01E
5,084
5078NCI-GLOSSNCI Dictionary of Cancer Terms,
1105E125
2023_01E
5659NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_01E
129NCI-HL7NCI Health Level 7,
1105E
2023_01E
514
509NCPDPNational Council for Prescription Drug Programs
, 1105E715
, 2023_01E
5NDCNational Drug Code, 2023_01E
4782NICHDNational Institute of Child Health and Human Development,
1105E
2023_01E
37ORCHESTRAORCHESTRA, 2023_01E
1832PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database,
1105E
2021_01D
310RENIRegistry Nomenclature Information System
, 1105E287
, 2023_01E
658SeroNetSerological Sciences Network Terminology, 2023_01E
1496UCUMUnified Code for Units of Measure,
1105E
2023_01E
40WHOWorld Health Organization (WHO) Terminology, 2023_01E
25ZFINZebrafish Model Organism Database,
1105E
2023_01E

NCIm concepts

Source Label - Other

Source Name

15,870
15884AODAlcohol and Other Drug Thesaurus, 2000
278
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
1,104
CCS
541CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2021
356CCSR_ICD10PCSClinical Classifications Software
, 20053,073
Refined for ICD-10-PCS, 2021
962CDCRECRace & Ethnicity - CDC, 1.2
3079COSTARCOSTAR, 1989-1995
16,572
16495CSPCRISP Thesaurus, 2006
3,836
3840CSTCOSTART, 1995
345
318CTEPCancer Therapy Evaluation Program, 2004
7,278
562CVXVaccines Administered, 2017_02_08, 2022_06_23
9795DRUGBANKDrugBank, 5.0_2016_06_22, 5.0_2022_08_01
7288DXPDXplain, 1994
77,923
102563FMAFoundational Model of Anatomy Ontology,
2_054,439
4_15
7485GARDGenetic and Rare Diseases Information Center, 2015_04
71529GOGene Ontology,
2010
2022_
04
05_
01
16
5,602
7836HCPCSHealthcare Common Procedure Coding System,
20107,483
2022
43131HGNCHUGO Gene Nomenclature Committee, 2022_04
9068HL7V3.0HL7 Vocabulary Version 3.0,
2006
2021_
05
12
29,335
18309

HUGO

HUGO Gene Nomenclature, 2010_05

11,532

ICD10

ICD10, 1998

1,004

ICD10AE

ICD10, American English Equivalents, 1998

97,631
HPOHuman Phenotype Ontology, 2022_06_11
17423ICD10ICD10, 2016
104884ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2010_03181,116
2023
191276ICD10PCSICD-10-PCS,
2009
2023
20,779
20937ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification,
2011
2014
2,466
2868ICDOInternational Classification of
Diseases
Disease for Oncology,
3rd Edition, 2000
3_2
748ICPCInternational Classification of Primary Care, 1993
37,923

ICPC2ICD10ENG

ICPC2 - ICD10 Thesaurus, 200412

80,206

LNC

Logical Observation Identifier Names and Codes, 232
5055ISO3166-2International Organization for Standardization 3166-2, 2012
172335LNCLOINC, 273
41MCMMcMaster University Epidemiology Terms, 1992
331
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
47,210
60491MDRMedical Dictionary for Regulatory Activities Terminology
, 14.01,897
(MedDRA), 25_1
3475MED-RTMedication Reference Terminology, 2022_09_06
2110MEDLINEPLUSMedlinePlus Health Topics,
20080614
2021_10_23
900MGEDMGED Ontology, 131
310,485
451526MSHMedical Subject Headings,
2011
2023_
2010
2022_
08
07_
30
27
85,138
217126MTHUMLS Metathesaurus,
2010AB
2022AB
19,880
11
MTHFDA
MTHCMSFRFMetathesaurus
FDA National Drug Code Directory, 2010_08_02
337

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2010

16,081
CMS Formulary Reference File, MTHCMSFRF_2014
19008MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms,
2011
2014
94

MTHICPC2ICD107B

ICPC2 - ICD10 Thesaurus, 7-bit Equivalents, 0412

76

MTHICPC2ICD10AE

ICPC2 - ICD10 Thesaurus, American English Equivalents, 0412

1,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
12,969
71639MTHSPLMetathesaurus FDA Structured Product Labels,
2010
2022_08_
27478,187
26
87MVXManufacturers of Vaccines, 2022_09_06
2062306NCBINCBI Taxonomy,
2010
2022_04_29
135
8699NCIMTH

NCI Metathesaurus

38,863

NDFRT

National Drug File, 2010_09_07

1,781
NCIMTH
0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research,
2010
2011_
10
12_
31
08
63,924
100815OMIMOnline Mendelian Inheritance in Man,
2010
2022_
04
07_
08
25
9,869
12398PDQPhysician Data Query,
2010
2016_
08
07_
06
31
2,041
2039PMAPortfolio Management Application, 2010
268
270PNDSPerioperative Nursing Data Set,
2nd edition, 2002
2021
940QMRQuick Medical Reference (QMR), 1996
30,033
45832RADLEXRadLex,
3
4_
33
1
227,498
201229RXNORMRxNorm Vocabulary,
10AA
20AA_
100907F
220906F
281,843
356057SNOMEDCT_US

SNOMED Clinical Terms

4,808
US Edition of SNOMED CT, 2020_09_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
156
224SRCMetathesaurus Source Terminology Names
13,788
28915UMDUMDNS: product category thesaurus,
20101,765
2022
5005USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines,
2004
2020
61,191
61112UWDAUniversity of Washington Digital Anatomist, 1.7.3
26,546
37499VANDFVeterans Health Administration National Drug File,
2010
2020_
07_26
08_03

Overall Counts (May 2023)

ConceptsRelationships Attributes Total Number of Terms
4,002,414

26,481,435

 29,294,274 8,917,525