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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
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NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 50125,000 out of the 120178,000 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1923.12e11D: December 2019November 2023)

Image RemovedImage Added

NCIt concepts with tagged synonyms from each outside source (1323.03d11D: March 2013November 2023)

1,149

NCIt Concepts

Source

3
335

BIOCARTA

ACC
1182ACC/AHA
2016

BRIDG

1148BRIDG 3.0.3
27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

408CareLex
56CBDD
268

CCPS

27578CDISC
794CDISC-GLOSS
2409Cellosaurus
3655CPTAC
406CRCH
8924CTCAE
280CTDC
427CTEP
27941CTRP
636DIPG/DMG
1069EDQM-HC
27959FDA
239GAIA
12046GDC
1422HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5661mCode
1281MedDRA
23NAACCR
245NCCN
510NCPDP
6NDC
4784NICHD
826OORO
71ORCHESTRA
1863PCDC
40PI-RADS
377SEER
662SeroNet
237UBERON
284UCUM
25
ZFin

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908202302:  August 2019May 2023)

1149    201907E20    2019_07E201 International Neonatal 201907E156 Jackson Laboratories 201907E244  Pathway Database, 2019_07E5077  of Cancer 201907E5001  201907E129  201907E540  Council for 201907E   201907E4782    2019_07E39    201907E169    201907E310    , 2019_07E1361    2019_07E 25   201907E

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_01E
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2023_01E
27BRIDGBiomedical Research Integrated Domain Group Model, 2023_01E
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2023_01E
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2023_01E
18643caDSRCancer Data Standards Registry and Repository, 2023_01E
334

BioC

BioCarta online maps of molecular pathways, adapted for NCI use, 2019_07E
407CARELEXContent Archive   Resource Exchange Lexicon, 20192023_07E01E40
53CBDDChemical Biology and Biology and Drug Development Vocabulary, 2019_07E2023_01E
265CCPSChildhood Cancer Predisposition Study, 2023_01E
923CDCU.S. Centers for   Disease Control and Prevention, 20192023_07E01E714
28026CDISC-GLOSSClinical Data   Interchange Standards Consortium Glossary Terms, 20192023_07E01E21313
795CDISC-GLOSSClinical Data   Interchange Standards Consortium , 2019_07E3657Glossary Terms, 2023_01E

2296

CELLOSAURUSCellosaurus, 2023_01E
3685CPTACClinical Proteomic   Tumor Analysis Consortium, 20192023_07E01E
406CRCHCancer Research   Center of Hawaii Nutrition Terminology, 2023_01E
775CTCAECommon Terminology Criteria for Adverse Events, 20192023_07E01E
5599CTCAE_3Common Terminology   Criteria for Adverse Events 3.0, 20192023_07E01E
4022CTCAE_5Common Terminology   Criteria for Adverse Events 5.0, 20192023_07E01E
770276CTCAECTDCClinical Trial Data Commons, 2023_01ECommon Terminology   Criteria for Adverse Events, 2019_07E
373CTEP-SDCCancer Therapy   Evaluation Program - Simple Disease Classification, 20192023_07E01E
2134327053CTRPClinical Trials   Reporting Program, 20192023_07E01E
903904DCPNCI Division of   Cancer Prevention Program, 20192023_07E01E
114DICOMDigital Imaging   Communications in Medicine, 2019_07E, 2023_01E
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_01E
695694DTPNCI Developmental   Therapeutics Program, 20192023_07E01E
10091050EDQM-HCEuropean   Directorate for the Quality of Medicines & Healthcare, 20192023_07E01E
2185726703FDAU.S. Food and Drug   Administration, 20192023_07E01E
207GAIAGlobal Alignment of   Immunization Safety Assessment in pregnancy, 2019_07E2023_01E
5591GDCNCI Genomic Data Commons, 2023_01E
281GENCGeopolitical   Entities, Names, and Codes Standard, 2019_07E2023_01E
106ICD-10International Classification of Diseases, 10th Edition, 2023_01E
693ICDCNCI Integrated Canine Data Commons, 2023_01E
215ICHInternational   Conference on Harmonization, 20192023_07E01E
215INCInternational Neonatal Consortium, 2023_01E
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2023_01E
244KEGGKEGG Pathway Database, 2023_01E
173066NCINational Cancer Institute Thesaurus, 2023_01E
5078NCI-GLOSSNCI Dictionary of Cancer Terms, 2023_01E
5659NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_01E
129NCI-HL7NCI Health Level 7, 2023_
146328NCINational Cancer Institute Thesaurus, 2019_07E
01E
509NCPDPNational Council for Prescription Drug Programs, 2023_01E
5NDCNational Drug Code, 2023_01E
4782NICHDNational Institute of Child Health and Human Development, 2023_01E
37ORCHESTRAORCHESTRA, 2023_01E
1832PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 2023_01E
658SeroNetSerological Sciences Network Terminology, 2023_01E
1496UCUMUnified Code for Units of Measure, 2023_01E
40WHOWorld Health Organization (WHO) Terminology, 2023_01E
25ZFINZebrafish Model Organism Database, 2023_01E

NCIm concepts

Source Label - Other

Source Name

15,873
15884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
622
541CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2021
356CCSR_ICD10PCSClinical Classifications Software
, 20053,080
Refined for ICD-10-PCS, 2021
962CDCRECRace & Ethnicity - CDC, 1.2
3079COSTARCOSTAR, 1989-1995
16,501
16495CSPCRISP Thesaurus, 2006
3,843
3840CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
435
562CVXVaccines
 
Administered,
2018
2017_
10
02_
18
08,
2019
2022_
03
06_
04
23
7,711
9795DRUGBANKDrugBank,
 
5.0_2016_06_22, 5.0_
2019
2022_08_01
_31
7,293
7288DXPDXplain, 1994
102,404
102563FMAFoundational Model
 
of Anatomy Ontology, 4_
10
15
7,503
7485GARDGenetic and Rare
 
Diseases Information Center, 2015_04
70,289
71529GOGene Ontology,
  2018
2022_05_
20
16
6,655
7836HCPCSHealthcare Common
 
Procedure Coding System,
2019
2022
41,301
43131HGNCHUGO Gene
 
Nomenclature Committee,
2018
2022_
03
04
9,789
9068HL7V3.0HL7 Vocabulary
 
Version 3.0,
2018
2021_
08
12
15,301
18309HPOHuman Phenotype
 
Ontology,
2018
2022_06_11
_08102,167
17423ICD10ICD10, 2016
104884ICD10CMInternational
 
Classification of Diseases, 10th Edition, Clinical Modification,
2019
2023
190,389
191276ICD10PCSICD-10-PCS,
201917,425ICD10ICD10, 201620,941
2023
20937ICD9CMInternational
 
Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2,588
2868ICDOInternational
 
Classification of Disease for Oncology, 3_
1
2
748ICPCInternational
 
Classification of Primary Care, 1993
5,057
5055ISO3166-2International
 
Organization for Standardization 3166-2, 2012
146,331
172335LNCLOINC,
265
273
41MCMMcMaster University
 
Epidemiology Terms, 1992
332MDBCACMitelman Database
 
of Chromosome Aberrations in Cancer, 2005_12
56,014
60491MDRMedical Dictionary
 
for Regulatory Activities Terminology (MedDRA),
22.03,315
25_1
3475MED-RTMedication
 
Reference Terminology,
2019
2022_
03
09_
04
06
2,119
2110MEDLINEPLUSMedlinePlus Health
 
Topics,
20181108
2021_10_23
900MGEDMGED Ontology, 131
373,575 
451526
 MSH
MSHMedical Subject Headings,
2019
2023_
2019
2022_
01_07
07_27
217126MTHUMLS Metathesaurus, 2022AB
11
9
MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2014
521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021
19008MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
58,600
71639MTHSPLMetathesaurus FDA Structured Product Labels,
2019
2022_
02
08_
22194,860

MTH

UMLS Metathesaurus, 2019AA

76
26
87MVXManufacturers of Vaccines,
2018
2022_
08
09_
31 1,409,501 NCBI
06
2062306NCBINCBI Taxonomy,
  2018
2022_04_
19
29
 5,749
8699NCIMTHNCIMTH
0NCISEERNCI SEER ICD
 
Neoplasm Code Mappings, 1999
NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_0539,434 NDFRTNational Drug File,   2018_02_051,887  NPO
1887NPONPO: NanoParticle
 
Ontology for Cancer Nanotechnology Research, 2011_12_08
106,313
100815OMIMOnline Mendelian
 
Inheritance in Man,
2019
2022_
02
07_
04
25
12,399
12398PDQPhysician Data
 
Query, 2016_07_31
2,039
2039PMAPortfolio
 
Management Application, 2010
260
270PNDSPerioperative
 
Nursing Data Set,
4_2018
2021
940QMRQuick Medical
 
Reference (QMR), 1996
45,733
45832RADLEXRadLex,
3
4_
15
1
201,450
201229RXNORMRxNorm Vocabulary,
  18AB
20AA_
190304F
220906F
347030
356057SNOMEDCT_USUS Edition of
 
SNOMED CT,
2019
2020_
03
09_01
162
167SOPSource of Payment
 
Typology,
84,810
9.2
4811SPNStandard Product
 
Nomenclature, 2003
200
224SRCMetathesaurus
 
Source Terminology Names
27,283
28915UMDUMDNS: product
 
category thesaurus,
2019 1,693 USPMGUSP Medicare Model   Guidelines, 2017 4,352 USPUSP Compendial   Nomenclature, 2018_12_1061,112
2022
5005USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines, 2020
61112UWDAUniversity of
 
Washington Digital Anatomist, 1.7.3
34,194
37499VANDFVeterans Health
 
Administration National Drug File,
2019
2020_
02
08_
01
03

Overall Counts (August 2019May 2023)

ConceptsRelationships Attributes Total Number of Terms
34,265002,686414

2226,852481,144435

 25 29,184294,657274 7 8,508917,907525