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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117125,000 out of the 154178,946 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (2124.05a02D: May 2021February 2024)

Image RemovedImage Added

NCIt concepts with tagged synonyms from each outside source (2124.05a02D: May 2021February 2024)

716552189436614262456210305684243298

NCIt Concepts

Source

3ACC
1182ACC/AHA
20172016

BRIDG

408CareLex
56CBDD
267268

CCPS

27790CDISC
769799CDISC-GLOSS
20672413Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
427CTEP
28210CTRP
636DIPG/DMG
1072EDQM-HC
2621028444FDA
239GAIA
12266GDC
1466HemOnc
127HL7
106ICD-10
664602ICDC
216ICH
215INC
5660mCode
1281MedDRA
23NAACCR
246NCCN
510NCPDP
6NDC
4784NICHD
826OORO
71ORCHESTRA
18631196PCDC
40PI-RADS
377SEER
662SeroNet
237UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908202402:  August 2019February 2024)

713 202101D 202101D 202101D1026 202101D24499 202101D 202101D5055 202101D, 2021_01D632 202101D 202101D 202101D 202101D 2021_01D158661 202101D5077 202101D5158 202101D 202101D 202101D 202101D4781 2021_01D879 202101D 202101D 202101D 2021_01D1437, 2021_01D 202101D

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_12D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2023_12D
27BRIDGBiomedical Research Integrated Domain Group Model, 20212023_01D12D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 20212023_01D12D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 20212023_01D12D
1725419304caDSRCancer Data Standards Registry and Repository, 20212023_01D12D
407CARELEXContent Archive Resource Exchange Lexicon, 20212023_01D12D
4953CBDDChemical Biology and Drug Development Vocabulary, 2021_01D, 2023_12D
265CCPSChildhood Cancer Predisposition Study, 2023_12D
922923CDCU.S. Centers for Disease Control and Prevention, 20212023_01D12D
2332429019CDISCClinical Data Interchange Standards Consortium, 20212023_01D12D
770800CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 20212023_01D12D
2000

2425

CELLOSAURUSCellosaurus, 20212023_01D12D
36883680CPTACClinical Proteomic Tumor Analysis Consortium, 20212023_01D12D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 20212023_01D12D
775CTCAECommon Terminology Criteria for Adverse Events, 20212023_01D12D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 20212023_01D12D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 20212023_01D12D
276CTDCClinical Trial Data Commons, 20212023_01D12D
318372CTEPCancer Therapy Evaluation Program, 2004373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 20212023_01D12D
2367528023CTRPClinical Trials Reporting Program, 20212023_01D12D
903904DCPNCI Division of Cancer Prevention Program, 20212023_01D12D
114DICOMDigital Imaging Communications in Medicine, 2021_01D2023_12D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_12D
694DTPNCI Developmental Therapeutics Program, 2023_12D
1070EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_12D
27355FDAU.S. Food and Drug Administration, 2023_12D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_12D
6030GDCNCI Genomic Data Commons, 2023_12D
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_12D
1439HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2023_12D
106ICD-10International Classification of Diseases, 10th Edition, 2023_12D
693ICDCNCI Integrated Canine Data Commons, 2023_12D
215ICHInternational Conference on Harmonization, 2023_12D
215INCInternational Neonatal Consortium, 2023_12D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2023_12D
244KEGGKEGG Pathway Database, 2023_12D
5660mCodeMinimal Common Oncology Data Elements, 2023_12D
183778NCINational Cancer Institute Thesaurus, 2023_12D
5079NCI-GLOSSNCI Dictionary of Cancer Terms, 2023_12D
5860NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_12D
129NCI-HL7NCI Health Level 7, 2023_12D
509NCPDPNational Council for Prescription Drug Programs, 2023_12D
5NDCNational Drug Code, 2023_12D
4780NICHDNational Institute of Child Health and Human Development, 2023_12D
825OOROOperational Ontology for Radiation Oncology, 2023_12D
70ORCHESTRAORCHESTRA, 2023_12D
1832PCDCPediatric Cancer Data Commons, 2023_12D
39PI-RADSProstate Imaging Reporting and Data System, 2023_12D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2023_12D
310RENIRegistry Nomenclature Information System, 2023_12D
659SeroNetSerological Sciences Network Terminology, 2023_12D
236UBERONUBERON Ontology, 2023_12D
1546UCUMUnified Code for Units of Measure, 2023_12D
77WHOWorld Health Organization (WHO) Terminology, 2023_12D
25ZFINZebrafish Model Organism Database, 2023_12D

NCIm concepts

Source Label - Other

Source Name

15,873
15884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
622
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2023
357CCSR_ICD10PCSClinical Classifications Software
, 20053,080
Refined for ICD-10-PCS, 2023
962CDCRECRace & Ethnicity - CDC, 1.2
3080COSTARCOSTAR, 1989-1995
16,501
16485CSPCRISP Thesaurus, 2006
3,843
3839CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
435
618CVXVaccines
 
Administered,
2018
2017_
10
02_
18
08,
2019
2023_
03
08_
04
16
7,711
11414DRUGBANKDrugBank,
 
5.0_
2016
2023_
06_22, 5.0_2019_01_317,293
08_11
7290DXPDXplain, 1994
102,404
102551FMAFoundational Model
 
of Anatomy Ontology, 4_
10
15
7,503
7482GARDGenetic and Rare
 
Diseases Information Center, 2015_04
70,289
71881GOGene Ontology,
  2018
2023_05_
20
10
6,655
8081HCPCSHealthcare Common
 
Procedure Coding System,
2019
2023
41,301
43627HGNCHUGO Gene
 
Nomenclature Committee,
2018
2023_
03
04
9,789
9078HL7V3.0HL7 Vocabulary
 
Version 3.0,
2018
2023_
08
02
15,301
19235HPOHuman Phenotype
 
Ontology,
2018
2023_
11_08102,167
07_21
17416ICD10ICD10, 2016
105376ICD10CMInternational
 
Classification of Diseases, 10th Edition, Clinical Modification,
2019
2024
190,389
191545ICD10PCSICD-10-PCS,
201917,425ICD10ICD10, 201620,941
2024
20886ICD9CMInternational
 
Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2,588
2864ICDOInternational
 
Classification of Disease for Oncology, 3_
1
2
748ICPCInternational
 
Classification of Primary Care, 1993
5,057
5055ISO3166-2International
 
Organization for Standardization 3166-2, 2012
146,331
175623LNCLOINC,
265
276
41MCMMcMaster University
 
Epidemiology Terms, 1992
332MDBCACMitelman Database
 
of Chromosome Aberrations in Cancer, 2005_12
56,014
62093MDRMedical Dictionary
 
for Regulatory Activities Terminology (MedDRA),
22.03,315
26_1
3523MED-RTMedication
 
Reference Terminology,
2019
2023_
03
09_
04
05
2,119
2123MEDLINEPLUSMedlinePlus Health
 
Topics,
20181108
20221101
900MGEDMGED Ontology, 131
373,575 
456461
 MSH
MSHMedical Subject Headings,
2019
2024_
2019
2023_
01_079
08_03
218961MTHUMLS Metathesaurus, 2023AB
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_
2014
521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021
2020
19007MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
58,600
57391MTHSPLMetathesaurus FDA Structured Product Labels,
2019
2023_
02
08_
22
24
194,860

MTH

UMLS Metathesaurus, 2019AA

76
88MVXManufacturers of Vaccines,
2018
2023_
08
09_
31 1,409,501 NCBI
06
719490NCBINCBI Taxonomy,
  2018
2023_04_
19
13
 5,749
9532NCIMTHNCIMTH
0 
1887
NCISEERNCI SEER ICD   Neoplasm Code Mappings, 19990 NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_050 NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_0539,434 NDFRTNational Drug File,   2018_02_051,887  NPO
NPONPO: NanoParticle
 
Ontology for Cancer Nanotechnology Research, 2011_12_08
106,313
103963OMIMOnline Mendelian
 
Inheritance in Man,
2019
2023_
02
08_
04
10
12,399
12399PDQPhysician Data
 
Query, 2016_07_31
2,039
2039PMAPortfolio
 
Management Application, 2010
260
270PNDSPerioperative
 
Nursing Data Set,
4_2018
2021
940QMRQuick Medical
 
Reference (QMR), 1996
45,733
45826RADLEXRadLex,
3
4_
15
1
201,450
217864RXNORMRxNorm Vocabulary,
  18AB
20AA_
190304F
230905F
347030
361058SNOMEDCT_USUS Edition of
 
SNOMED CT,
2019
2023_
03
09_01
162
167SOPSource of Payment
 
Typology,
84,810
9.2
4811SPNStandard Product
 
Nomenclature, 2003
200
230SRCMetathesaurus
 
Source Terminology Names
27,283
29104UMDUMDNS: product
 
category thesaurus,
2019 1,693 USPMGUSP Medicare Model   Guidelines, 2017 4,352 USPUSP Compendial   Nomenclature, 2018_12_1061,112
2023
5002USPUSP Compendial Nomenclature, 2023_08_17
1605USPMGUSP Medicare Model Guidelines, 2020
61107UWDAUniversity of
 
Washington Digital Anatomist, 1.7.3
34,194
38334VANDFVeterans Health
 
Administration National Drug File,
2019
2023_
02
07_
01
31

Overall Counts (August 20192023)

ConceptsRelationships Attributes Total Number of Terms
32,265684,686035

2223,852500,144918

 25 24,184395,657137 7,508098,907885