To Print the Guide
We recommend you print one wiki page of the guide at a time. To do this, click the printer icon at the top right of the page; then from the browser File menu, choose Print. Printing multiple pages at one time is more complex. For instructions, refer to How do I print multiple pages?.
Selecting a Disease Search Term
The Simple Search tool creates an auto-populated list of caBIO terms that match the characters you have entered (1). Thus, you may select any of these suggested terms that match your disease concept of interest (e.g., "ovarian serous cystadenocarcinoma") to search for objects that match the term. If you would like to use a more general search term in order to retrieve objects that are associated with more than one disease term (e.g., any cancer term associated with the ovary), you may use the "*" wild card character, which will replace zero or more characters (e.g., a search for "ovar*").
Once you have found a search term (1), click the Search button (2). If you would like, you may refine your search by clicking the Advanced Options (3). The Exclude field allows you to exclude objects that match your desired terms. You may select the format for retrieved results as lists of "simple" records, the default setting, or as objects. The Simple view returns at most three pieces of information from each retrieved object: the object name in blue text, miscellaneous data specific to the object's type in black text, and the type name in green text. You can view all of the object's attributes and data by clicking on the blue object name link. Alternatively, the Objects view will give a list of all attributes and metadata from retrieved objects. Due to space constraints and the nature of the Simple Search (i.e., you must click through to a separate caBIO viewer to find the desired genes or diseases and compounds), you will likely not find this view to be a useful option. You may also increase the number of results per page from the default value of five to either ten or fifteen. Finally, if you enter multiple keywords, you may define whether to search for objects with attributes that contain any of the keywords, the default setting or that contain all of the keywords. This advanced option is only useful if you do not take advantage of the auto-populated list of matched search options.
Search Tip
It is strongly advised for you to select 15 returned results per page from the Advanced Options.
Simple Search Tool Retrieved Results
Simple Search queries retrieve lists of caBIO objects. The list is formatted such that three pieces of information are shown for each object - a blue link to all of the object's attributes and data, type-specific information (here, an EVS ID for Disease Ontology, EST for Library, and a disease alias for Protocol Association) in black text, and the object's type in green text. You do not have to first search the NCI Thesaurus to find an appropriate search term or code. Review the list of retrieved objects, clicking through to subsequent results pages, until you find an Evidence type object (green box).
Once you click on the object's name, you may review the sentence, sentence status flag, cell line indicator, and negation indicator data for the object (1). For more information on these items, refer to the Data, Metadata, and Annotations section. In order to view the gene associated with this piece of evidence, you must use the caBIO Object Graph Browser.
Warning!
If you do not want to spend time navigating through the caBIO object model for candidate gene-compound/agent associations that were found to be false positives, unclear, or redundant to other data, you should first view the check that the sentenceStatus attribute is set to finished (1) before opening the caBIO Viewer (2).
To open the browser, click the Open this record in the caBIO Object Graph Browser link at the bottom of the page (2). A new window or tab in your web browser should open and display the Evidence type object. To return to the list of retrieved results, you may return to the Simple Search window or tab in your web browser and click the "Return to results" link (3).
You must scroll to the right and click the getGeneFunctionAssocationCollection method link. Next, click the getGene method link in the GeneDiseaseAssociation type object to view the associated gene's full name and HUGO Gene Symbol in the fullName and hugoSymbol columns of the {{Gene type object (3).
Disease Ontologies
caBIO also contains disease ontology information. Should you wish to find parent and child concepts for your disease search term in order to perform additional searches using these disease terms (or, alternatively, nagivate through the object model to find gene-disease association information for these disease terms), click getDiseaseOntology on the GeneDiseaseAssociation view. You can find parent disease concepts by scrolling to the right and selecting the getParentDiseaseOntologyRelationshipCollection link; child disease concepts can be accessed by clicking on the getParentDiseaseOntologyRelationshipCollection link.
Warning!
caBIO may not always contain the most up-to-date disease ontology data from the NCI Thesaurus. If the disease concept of interest has neither parent nor child concepts, search the NCI Thesaurus using your disease term or EVS ID listed in the EVSid column of the Disease Ontology object, if you have not done so already.
INSERT DISEASE ONTOLOGY BROWSER FIGURE HERE
