 |
Accessibility
| Contact CBIIT | FOIA | HHS Vulnerability Disclosure | Comment Policy
U.S. Department of Health and Human Services | National Institutes of Health | National Cancer Institute | USA.gov
NIH ... Turning Discovery Into Health®
Powered by Atlassian Confluence, themed by RefinedTheme
Oct 10, Group Discussion, Integrative Genomics Viewer, UCSC Xena, Single Cell Genome Viewer
Integrative Genomics Viewer
UCSC Xena
Single Cell Genome Viewer (Profiling and visualization of tumor genomes on a single-cell level) - Sparse genomic profiling of multiple individual cancer cells is a tool of choice for characterization of genetic heterogeneity and clonal structure in tumors. I will outline a computational and visualization workflow we have developed for this purpose and provide evidence for diagnostic utility of single-cell genomics in prostate cancer
Session details...
BIOS:
Helga Thorvaldsdottir is a Software Engineering Manager at the Broad Institute. Helga holds an MS in Computer Science from the University of North Carolina at Chapel Hill, where she focused on interactive 3D computer graphics. After a decade developing computer graphics software for hardware companies in Silicon Valley, Helga turned her attention to software development for biomedical researchers, first at Iceland Genomics Corporation and then the Broad Institute. Helga has been a key member of the team that develops the Integrative Genomics Viewer (IGV) since before its initial release in 2008.
Mary Goldman bio to be included
Alexander Krasnitz and colleagues develop mathematical and statistical tools to investigate population structure of cells comprising a malignant tumor and to reconstruct evolutionary processes leading up to that structure. These tools are designed to make optimal use of emerging molecular technologies, chief among them high-throughput genomic profiling of multiple individual cells harvested from a tumor. By analyzing these profiles, Krasnitz derives novel molecular measures of malignancy, such as the number of aggressive clones in a tumor, the invasive capacity of each clone and the amount of cancer-related genetic alteration sustained by clonal cells. Krasnitz and colleagues collaborate closely with clinical oncologists to explore the utility of such measures for earlier detection of cancer, more accurate patient outcome prediction and risk assessment, and better-informed choice of treatment options.
SUMMARY:
Topics/Speakers:
Date: Wednesday, October 10, 2018
Time: 11 AM – 12 PM ET
Room: 1W032-034 and 2E908
WebEx: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=effcf2649de66e0a87388f09f46ee0414
Event ID: 858 917 039
Event Password: $Peakerseries18
You are invited to listen to all speaker presentations in the NCI Shady Grove Building on Medical Center Drive or via WebEx. All speakers will present remotely via WebEx.
Presentation: A screencast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series presents talks from innovators in the research and informatics communities. The biweekly presentations allow thought leaders to share their work and discuss trends across a diverse set of domains and interests. The goals of the Speaker Series are: to share leading-edge research; to inform the community of new tools, trends, and ideas; to inspire innovation, and to provide a forum from which new collaborations can begin. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.