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If your user account has the Write or Own permission level on an existing collection in DME, and if that existing collection has been configured to contain data files, you can upload a data file to that collection. The following table compares the functionality available with each command: 

CommandFile SystemGlobusPresignedMultipartUpdate Metadata
dm_register_dataobject Yes, up to 10 GBYesNoNoYes
dm_register_dataobject_presigned Yes, up to 2 GB (recommendation)NoYesNoNo
dm_register_dataobject_multipart YesNoYesYes, if the file is 50 MB or largerNo

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