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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Unknown User (leblancak)



Otridge, John (NIH/NCI) [C]



Kim, Erika (NIH/NCI) [E]


Sommers, Connie (NIH/NCI) [E]


X
Debbie Knapp

Toby Hecht

Unknown User (parchmentr)



Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


Agenda

ItemWhoTalking Points
DGAB Updates

Kuffel, Gina (NIH/NCI) [C] 

Recently Released

  • OSA03
    • "Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma"
    • University of Minnesota
    • 44 cases, 88 files (1.54 TB)
    • Status: Released on 5/24/23

ICDC Studies in Active Submission

  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Data has been loaded to the Dev tier
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

  • 2022 BPSC Review Article

    The manuscript entitled "Leading the Pack: Best Practices in Comparative Canine Cancer Genomics to Inform Human Oncology" has been successfully submitted online and is being delivered to the Editorial Office of Veterinary and Comparative Oncology for consideration.

Upcoming Steering Committee Meeting

Unknown User (parchmentr)

  • Enter date
  • Proposed Agenda:
Next Software Release

Kuffel, Gina (NIH/NCI) [C] 

  • Target date is June 20, 2023
  • New Features
    • 2 new tabs on the Study Details page, one for supporting data and the other for clinical data observations
    • Full-text search for JBrowse
    • Liftover tracks for gene annotations from human hg38 to canFam genomes
    • Updated UI design for "My Files" Cart Page
    • Button for exporting a file manifest directly to the CGC

Minutes (Not Verbatim)





Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

TH - Look at drug responses and the tumor itself to determine if there is a biomarker based on genomic expression. In the Intro of the BPSC paper, we could give examples of things that can be done based upon existing drug trial studies. 

AL - In general, there is such a scarcity of credentialed biology in tumor progression. Drug mechanisms can be highlighted with an imaging reporter. 

DK - Pre and post biopsies were attempted in Vemurafinib trial

AL - Until we have DBs to refer to and a more stable reference genome it is difficult to make progress.



Action items

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