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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Amy Leblanc

Otridge, John (NIH/NCI) [C]



Kim, Erika (NIH/NCI) [E]


Sommers, Connie (NIH/NCI) [E]



Debbie Knapp

Toby Hecht

Ralph Parchment

Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


  • Debbie to work with Ralph to write invitation for Jaime Modiano
  • Gina to speak with Debbie to arrange a meeting with Gerry to discuss data submission (Toby, Debbie, Phil)
  • Revisit new steering committee members in September (loop Connie into this discussion) 

Agenda

ItemWhoTalking Points
Discussion with FidoCure

Dr. Gerald Post, Chief Medical Officer at FidoCure

Ben Toussant, Vice President of Operations at FidoCure

  • Goals of the ICDC
  • Types of data that FidoCure has
  • Potential collaborations
  • Data submissions
New ICDC Subcommittee: Cross-Species Mapping Committee (CSMC)

Purpose: Facilitation of human-canine comparative data analysis from the ICDC and other nodes in the CRDC using interoperability components such as Cancer Data Aggregator and aligning with data standards

All

  • ICDC Cross-Species Mapping Collaboration.docx 1-pager
  • Does this effort need a new subcommittee?
    • Nicky Mason and James Dattilo are interested
  • Activities
    • Build consensus data standards between human and canine data elements
    • Mapping existing data elements in the ICDC to caDSR II to facilitate the findability of canine data related to human data through platforms such as the Cancer Data Aggregator.  
  • How can we leverage a potential collaboration with Data for the Commons Good (DCG) team?
    • The DCG team is in the process of mapping data elements from the Pediatric Cancer Data Commons to caDSRII and is willing to work with us to share common data elements CDEs

New ICDC Subcommittee: Longitudinal Data Acquisition and Use Committee (LDAUC)

Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC.. 

All

DGAB Updates

Kuffel, Gina (NIH/NCI) [C] 

Recently Released

ICDC Studies in Active Submission

  • COTC021
    • Approved by SAC on 6/30/23
    • "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma"
    • Dr. Amy LeBlanc
    • Status: AWS creds have been provided for file transfer
  • UBC03
    • Approved by SAC on 8/13/22
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • Status: Metadata transfer is in progress
New ICDC Bioinformatics Tutorial Website

Kuffel, Gina (NIH/NCI) [C] 

ICDC Biospecimen Data

Kuffel, Gina (NIH/NCI) [C] 

Upcoming Steering Committee Meeting

Ralph Parchment

  • January meeting: 
  • Ralph will send out the minutes for approval

Minutes (Not Verbatim)

TH - Golden Retriever Lifetime study has contacted us with biospecimen data, they would like a discussion. Could we have a page within the application to redirect users to biospecimen data? We could let them know about the potential for displaying URLs for their biospecimen data. We could organize this data by type (ie. plasma, mast cell, circulating tumor cells, etc.), we could provide contact information at the consortium level).

JO - This can serve as a maturation of what the ICDC can do.

RP - It is possible that some of the golden retrievers are still being monitored. 

AL - Goldens are susceptible to all sorts of issues and diseases, it would be important to understand if they capture cancer specimens and diagnostic information.

EK - Sam is funded by the CCDI and is building data dictionaries for CCDI, confirming with the program that a collaboration would be supported.

JO - We are already working with Sam to implement platforms for CCDI.

TH - Gliomas can be studied in canine and pediatric data

AL - Osteosarcoma is another link

TH - In PRECINCT there was a trial in glioma that showed the significance between canine and pediatric data

JO - Another important resource to display within the ICDC could be relevant links to clinical trials from CCDI.

TH - We need to invite a rep from Pediatric Oncology to join the Steering Committee (could be a radiologist).

TH - We need to first figure out the plan of action for mapping canine/pediatric data and common data elements.

JO - Katherine Janeway from Dana Farber can be a potential 

AL - Ronnie Roberts from Nationwide Children's hospital

TO - Adam Resnick from CHOP could be a potential collaborator, he focuses on gliomas. 

AL - There is a new veterinary journal coming under the umbrella of Nature, I will be a co-editor, titled Nature Veterinary Oncology, I wanted to ask for a submission about the ICDC, perhaps a perspectives piece.


Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Action items

  • Toby to invite Greg from CCDI to the next Executive Team Meeting in January
  • Toby to look across the NCI directory to find person that has a combination of canine and pediatric oncology background
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