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SYNOPSIS:The CRIS effort at University of Arkansas for Medical Sciences (UAMS) began five years ago and has been highly influenced by the caBIG® program. The CRIS Suite includes 20+ open-source tools, which are deployed within a single portal environment, and it is evolving constantly towards the big-data paradigm. Our main success factor has been having a clear communications channel with and the support of the Cancer Institute and UAMS leadership. The investment has started to result in the campus-wide usage of CRIS and an increased informatics awareness throughout our research community. Moreover, the CRIS Initiative is taking part in the National Children’s Study, which involves collaborations with a number of other institutions (and more). Session details ...
BIO:
Dr. Umit Topaloglu is Assistant Professor of Biomedical Informatics and Director of Research in the Information Technology Department at the University of Arkansas for Medical Sciences (UAMS). He also serves as the Associate Directors for the Informatics Core of the Translational Research Institute and the Cancer Institute Informatics Core. He leads a team that successfully integrated/implemented several caBIG® and other clinical systems to create an open-source clinical and translational research infrastructure that encompasses clinical trials management, biobanking, -omics, and community engagement informatics. Dr. Topaloglu’s work involves semantic-concept discovery, UMLS terminologies, and open-source clinical research informatics tool development. He also participates in the Arkansas CyberInfrastructure Initiative through which state institutions and researchers are collaborating to enhance/implement a statewide cyberinfrastructure.
SUMMARY:
Topic: The Clinical Research Informatics Suite (CRIS)
Speaker: Dr. Umit Topaloglu
Date: Wednesday, October 3, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI Events YouTube Channel 
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:The use of genome-wide profiling technologies in basic and translational research is on the rise in the clinical setting. However, several potent informatics barriers must be overcome before clinical sequencing can become routine. Good Laboratory Practice-based quality-assurance metrics must be established to guarantee the accuracy required to make medical decisions. Genetic variants identified by sequencing must be systematically annotated and interpreted so that a clinical genomicist can decide which are medically actionable. Software applications and technologies are required to facilitate reporting of genomic results and to transmit these data to electronic health records. To address these issues, we have developed the Clinical Genomicist Workstation, which provides a “soup-to-nuts” solution for processing clinical sequencing orders. Session details ...
BIO:
Dr. Rakesh Nagarajan is an Assistant Professor in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis, Director of the Institute of Clinical and Translational Sciences, and Director of the Alvin J. Siteman Cancer Center for Biomedical Informatics. As Director of the Center for Biomedical Informatics, he and his group have developed and support broad biomedical informatics infrastructure to facilitate clinical and translational research as well as collaborate on clinical and genomic projects by providing in silico analyses and expertise. Trained as a physician-scientist, Dr. Nagarajan received his M.D. and Ph.D. degrees from Washington University in St. Louis in 2002.
SUMMARY:
Topic: Clinical Genomicist Workstation
Speaker: Dr. Rakesh Nagarajan, M.D., Ph.D.
Date: Wednesday, September 19, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI Events YouTube Channel
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:At Windber Research Institute, Dr. Hu and his colleagues have developed a biomedical informatics infrastructure to support multiple translational research programs, including the Clinical Breast Care Project and the Gynecological Disease Program. The system is composed of a data tracking system, a set of QA programs, and a data warehouse system. The data tracking system, named the Clinical Laboratory Workflow System, is used for managing daily activities including subject enrollment, clinicopathologic data collection, and tissue banking. The QA programs focus on clinical data, including a QA issue tracking system and a QAMetrics. In addition, a Data Warehouse for Translational Research was developed to integrate the clinicopathologic data and molecular data.
BIO:
Dr. Hai Hu is Senior Director of Biomedical Informatics and Deputy Chief Scientific Officer for the Windber Research Institute in Pennsylvania. He also serves as Adjunct Professor for the Shanghai Center for Bioinformation Technology in Shanghai, and for the Department of Surgery at the USUHS School of Medicine in Bethesda, MD. Dr Hu received his Ph.D. in Biophysics from the State University of New York at Buffalo.
SUMMARY:
Topic: Biomedical Informatics Infrastructure to Support Translational Research
Speaker: Dr. Hai Hu
Date: Wednesday, September 5, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI Events YouTube Channel
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:
Pathology, as a diagnostic specialty, is well along in its adoption and use of digital images for routine clinical workflow, research and education. However, with an anticipated deluge of image-based data, combined with the reality that many scientists within the collective domains of pathology and its affiliated life sciences specialties are largely unprepared to manage such large digital repositories, there emerges a challenge to make best use of this data. This presentation will highlight several promising areas of digital image algorithm development that can help to span the divide between life scientist and imaging informaticist, with a focus on actual workflow models. Session details ...
BIO:
Dr. Ulysses G. J. Balis is Associate Professor of Pathology and Director of the Division of Pathology Informatics in the Department of Pathology at the University of Michigan Medical School. Dr. Balis is a member of numerous professional societies including the Association for Pathology Informatics of which he was a founding member, served as Vice-President and is currently President-Elect. While at Massachusetts General Hospital (MGH), he developed and implemented a barcode tracking system for Anatomic Pathology Workflow. Dr. Balis has numerous publications in peer reviewed journals and has served as an invited speaker nationally and internationally in the area of informatics.
SUMMARY:
Topic: The Promises and Challenges of Digital Imaging As Applied to Pathology
Speaker: Dr. Ulysses G.J. Balis
Date: Wednesday, August 8, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI Events YouTube Channel
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:
The Radiation Therapy Oncology Group (RTOG) is a national clinical cooperative group that has been funded by the National Cancer Institute since 1968. Its aim is to improve survival and quality of life for patients diagnosed with cancer. The scope of RTOG encompasses all major cancer disease sites. Conducting research in the cooperative group setting requires a set of minimum standards and consistency; this is particularly relevant in the realm of technological assessment and innovation. In the re-organization of the cooperative groups as well as in the quality-assurance support groups, there are unique challenges regarding data acquisition and database infrastructure, as well as access to data. Data mining and analytical research remain crucial to achieving RTOG goals. Session details ...
BIO:
Dr. Ying Xiao is professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University. She is also a medical physicist certified by the American Board of Radiology and was recently elected a fellow of the American Association of Physicists in Medicine. Dr. Xiao is now the core laboratory physicist of RTOG and chairs the RTOG bioinformatics group.
SUMMARY:
Topic: Radiation Therapy Oncology Group (RTOG) BioInformatics
Speaker: Dr. Ying Xiao
Date: Wednesday, July 25, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI Events YouTube Channel
About the NCI CBIIT Speaker Series
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:
The Georgetown Database of Cancer (G-DOC) is designed to serve as a cutting-edge data integration platform and integrative knowledge discovery system for the oncology and translational research communities. By aggregating public and proprietary clinical and -omics data from across the Medical Center, G-DOC is expected to help bring about significant advances in personalized medicine for patients and to promote identification of new drug targets and therapeutic modalities. Dr. Madhavan's talk is titled, "G-DOC: A Novel Data Integration Platform to Enable Systems Medicine" Session details ...
BIO:
Dr. Madhavan is the Director of Clinical Research Informatics at the Lombardi Comprehensive Cancer Center at Georgetown University. Previously, she served as the Associate Director of Product and Program Management at NCI CBIIT, where she led the development of several bioinformatics programs, including The Cancer Genome Atlas (TCGA) project and the platform supporting the REpository of Molecular BRain Neoplasia DaTa (REMBRANDT) project. Dr. Madhavan holds a doctorate in molecular biology from the Uniformed Services University for Health Sciences.
SUMMARY:
Topic: G-DOC - The Georgetown Database of Cancer
Speaker: Dr. Subha Madhavan
Date: Wednesday, July 11, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
About the NCI CBIIT Speaker Series
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
BIO:
Dr. Stephen Chanock is a leading expert in the discovery and characterization of cancer susceptibility regions in the human genome. He has received a number of awards for his scientific contributions to our understanding of common inherited genetic variants associated with cancer risk and outcomes.
Dr. Chanock received his M.D. from Harvard Medical School in 1983 and completed clinical training in pediatrics, pediatric infectious diseases, and pediatric hematology/oncology and research training in molecular genetics at Boston Children’s Hospital and the Dana-Farber Cancer Institute, Boston. From 2001-2007, he served as a tenured investigator in the Genomic Variation Section of the Pediatric Oncology Branch in the NCI Center for Cancer Research. Previously, he served as co-chair of NCI's Genetics, Genomics and Proteomics Faculty for five years. In 2001, he was appointed as the Director of the Core Genotyping Facility, and in 2007 as Chief of the newly formed Laboratory of Translational Genomics, both within the intramural Division of Cancer Epidemiology and Genetics program. He has co-led the Cancer Genetic Markers of Susceptibility (CGEMS) project. Session details ...
SUMMARY:
Topic: Genome-wide Association Studies in Cancer
Speaker: Dr. Stephen Chanock
Date: Wednesday, June 20, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
About the NCI CBIIT Speaker Series
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: The cBio Cancer Genomics Portal is an open-access resource for interactive exploration of multidimensional cancer genomics data sets. The portal currently provides integrated access to cancer genomic data on more than 5000 tumor samples from 20 cancer studies. This presentation will provide an introduction to the portal and describe how to mine data generated by The Cancer Genome Atlas (TCGA) project. This is a virtual presentation. Session details ...BIO: Ethan Cerami is the Director of Cancer Informatics Development at the Computational Biology Center at Memorial Sloan-Kettering Cancer Center.
SUMMARY:
Topic: cBio Cancer Genomics Portal
Speaker: Ethan Cerami
Date: Wednesday, May 23, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
About the NCI CBIIT Speaker Series
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Researchers at Emory University, in collaboration with investigators at the University of Virginia, Henry Ford Hospital, and Thomas Jefferson Hospital, have been working to develop the Visually Accessible Rembrandt Images (VASARI) feature set, a standardized set of qualitative imaging features used to describe high-grade gliomas. Dr. Gutman will discuss current efforts to validate these data sets and present preliminary work on the use of imaging descriptors to stratify patients into subgroups with differential survival or genetic characteristics. Finally, Dr. Gutman will discuss emerging work to develop and validate 3-D, a volumetric-based quantitative assessment of brain tumors. Session details ...BIO: Dr. Gutman is an assistant professor in the department of Biomedical Informatics at Emory, and has a PhD in Neuroscience. Following his psychiatry residency at Emory, he took a position in the Center of Comprehensive Informatics where his work has focused on the analysis of both radiology and pathology images, as well as on developing the informatics infrastructure needed to process and analyze these images efficiently.
SUMMARY: Development and Validation of Radiology Descriptors in Gliomas
Speaker: David Gutman
Date: Wednesday, May 9, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page on our wiki page and on YouTube
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Unified Communications (UC) is growing at a rapid rate, and the technology in use today can connect researchers from around the world in a matter of minutes. Using UC technology, researchers are able to collaborate using high-definition video to share images, integrate scientific equipment, and eliminate borders. In this presentation, Mr. Cox will describe the solutions he has used to connect scientific equipment in the UC space and his development of advanced conference capabilities. Session details ...BIO: K. Todd Cox is a Lead Computer Specialist in the Center for Biomedical Informatics and Information Technology (CBIIT) at the National Cancer Institute. For the past two years he has managed the Unified Communications project at NCI where he and his team have been working to find ways to use technology and new media to help researchers achieve the Institute's mission.
SUMMARY: Applying Unified Communications (Video, Voice, and Collaboration) in the Battle Against Cancer
Speaker: K. Todd Cox
Date: Wednesday, April 25, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Molecular alterations in cancer cells can result in the expression of abnormal proteins or other translation products not observed in normal somatic cells. These cancer-specific translation products may be useful as therapeutic and imaging targets or as diagnostic markers. Martin McIntosh will present an overview of his work in identifying potential cancer-selective proteins using RNA-sequencing methods to characterize ovarian, prostate, and color cancer models.Martin McIntosh, Ph.D., is a Full Member at the Fred Hutchinson Cancer Research Center in Seattle, WA, and Principal Investigator of the Computational Proteomics Laboratory. His research is largely split between computational and laboratory activities involving a range of technologies for large-scale molecular profiling, including RNA sequencing, metabolomics, and proteomics.
Identifying Cancer-Selective Proteins Using RNA-Sequencing and Bioinformatics Strategies
Speaker: Martin McIntosh, Ph.D.
Date: Wednesday, April 11, 2012
Time: 11 AM – 12 PM
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
Eliot L. Siegel, MD, FACR, FSIIM, is a professor and vice chair of imaging informatics at the University of Maryland School of Medicine in Baltimore, where he heads the Maryland Imaging Research Technologies Laboratory. He is also chief of Imaging Services for the Maryland Veterans Affairs (VA) Healthcare System at the Baltimore VA Medical Center. Dr. Siegel is board certified in both radiology and nuclear medicine and a fellow of the Society for Imaging Informatics in Medicine as well as a fellow of the American College of Radiology. In addition, he is also the Lead Subject Matter Expert in the Cancer Biomedical Informatics Grid (caBIG®) In Vivo Imaging Workspace.
SYNOPSIS: The Jeopardy match between the two best human players of all time and the IBM Deep Q/A software, “Watson,” captured the spotlight and stimulated the imagination of the entire world. The subsequent announcement of IBM’s involvement in the creation of “Dr. Watson” has created a high level of interest in the healthcare community about the potential of this breakthrough technology as well as the potential pitfalls of the use of “artificial intelligence” in medicine. Dr. Siegel is currently working together with IBM engineers to explore how Dr. Watson can work together with physicians and medical specialists. His presentation on March 28th will provide a high level overview of the uniqueness of Deep Q/A Software and how it differs from other previous artificial intelligence applications.
Date: March 28, 2012
Time: 11:00 to 12:00 Noon
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
Join us on Wednesday March 14th at 11:00 am to hear Dr. Lee Cooper deliver a virtual presentation via Adobe Connect highlighting his recent publication, “Integrated morphologic analysis for the identification and characterization of disease subtypes.” Dr. Cooper is a postdoctoral researcher in the Center for Comprehensive Informatics at Emory University. He received a Ph.D. in Electrical Engineering from Ohio State University in 2009, where he worked to develop computational methods for image-based phenotyping in mouse models of breast cancer. Dr. Cooper joined Emory in 2009 where he works under the guidance of Joel Saltz to develop methods for analyzing and integrating genomic and imaging datasets to discover associations among pathology, genetics, and patient outcomes. While at Emory, Dr. Cooper has co-authored several methodological and scientific papers describing work performed at the Emory In Silico Brain Tumor Research Center.
Publication: PDF
Presentation: The presentation will be available for viewing after the event on our Speaker Series Videos page and on YouTube .
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
On February 29, from 11:00am to 12:00pm, Dr. Sanaz (Sunny) Jansen will be presenting on "Mouse models of GBM: MRI characterization and caBIG tools." She received her Ph.D. in Medical Physics from the University of Chicago in 2009. She is currently a postdoctoral fellow in the laboratory of Terry Van Dyke, Mouse Cancer Genetics Program, NCI-Frederick. Selected both as an NCI Sallie Rosen Kaplan Fellow and an NCI Frederick Cancer, Genetics and Signaling Fellow, Dr. Jansen recently received a Department of Defense Postdoctoral Award. Her research focus is on using genetically engineered mice to investigate quantitative image-based approaches to improving the detection and characterization of cancer. Details below:
Summary and Presentation: Mouse models of GBM: MRI characterization and caBIG tools (attached)
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
Welcome to the CBIIT Speaker Series, a new research and biomedical informatics knowledge-sharing initiative at the National Cancer Institute. Over the next few weeks, we will begin adding speakers to the calendar located at the bottom of this page, and will feature additional information about their topics and presentations in this "Running Updates" section. We are soliciting feedback on this series and recommendations for speakers, so please don't hesitate to give us your thoughts via email: NCICBIITComms@mail.nih.gov. All presentations will be made via an Adobe Connect webinar session, with details on how to connect and interact available in the blue box to the left. We look forward to sharing knowledge in this format and hope to extend it beyond the confines of NCI, so please let your colleagues know and encourage them to check it out. Thank you!
