2021-06-04 Meeting notes

Date

04 Jun 2021

Attendees

Todd, Toby, Debbie, Amy, John, Ralph, Erika, Connie
Regrets:

Goals

Discussion items

Item	Who	Notes
SC Meeting Notes	Ralph	Agenda for upcoming meeting on the 16th?
ICDC Next Phase	Toby	ICDC will be 3 years on TO, 2 more to go What's going to happen after the 5 years are up? Another Task Order? What specific tasks in years 6-10? Maintenance and data will be the base Are there specific items that haven't been attempted in the first 5 years? Discuss with the Steering committee Probably don't need decisions until next summer (2022) John - Infrastructure is in place, next piece would be comparative analysis? Are there datasets and/or tools, pipelines, etc. Toby - Would need some specific case studies. Here's the hypothesis and this is the data we need. That would drive the connections. Cloud Resource needs? Cost for data storage will land on ICDC Helping submitters put data into proper format, general submission support Outreach to submitters to get them informed early in their work. Tools, instructions to help them. Data loading, submission will become more automated Coming primarily from CRDC Toby - Would like a list of needs That is a PM task Ralph - Would ICDC host reference genomes? Other ground truth data? Normal tissue data? NCBI has 5 fully annotated dog genomes Elaine and her team are key to this, they have the most experience in normal genomes ICDC was started with the idea of catalyzing the dog community. Can it expand to provide this standard service? Be more than just a data commons. Perhaps something like a forum? Amy - There are examples where consensus have been published. Just a consensus on a reference genome would be a significant event This area (consensus approaches) is a very unmet need Debbie - compiling information and tools would be very helpful. Amy is working with NCATS to build transcriptional tools, one issue was trying to identify fusions, no current consensus. A white paper around this would be useful. ICDC Cookbook? Even if the consensus is that there is no reference genome and it needs to be breed-based, that would be a major advancement Is the Dog 10K project a source? Elaine would be best for information on this Erika - This conversation happened in the Non-Cancer group VCF files are publicly available ICDC may need some enhancements but could host this Allocation for training? How to use data in ICDC and connect to CRDC
ICDC Site	Todd	Target release date: Week of June 21st Features: Study Accession IDs Study Embargo notification File Download Multiparticipant support Publication listing Data Release UBC01 and UBC02 -Publications accepted, embargo lifting OSA01 - May be wrapped up shortly, no embargo Will coordinate with CBIIT Comms team for an announcement
ICDC TPM	Todd	Gina Kuffel will start June 21st
July/August meetings	Todd	Keep July meeting, drop August Task order - Really start things moving in July. Deposition of pathology images - June SC meeting FidoCure - Follow up? They are interested in providing data Revist at SC Fidocure has yet to define what they would submit NCI needed to understand any potential favoritism Toby - No possibility of favoritism, DGAB decides on if it is appropriate, Exec Comm then makes final decision If the consensus is that their approach isn't sufficient, that's a separate question. Wait for publication and then decide? That would be just sharing data that have been published Consensus is that waiting for publication is the preferred approach Concern about lack of followup data, not a lot of detailed information Sequencing data would be useful

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