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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Unknown User (leblancak)

X

Otridge, John (NIH/NCI) [C]


X
Kim, Erika (NIH/NCI) [E]
X

Sommers, Connie (NIH/NCI) [E]

X
Debbie Knapp
X
Toby HechtX

Unknown User (parchmentr)



Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


Agenda

ItemWhoTalking Points
DGAB Updates

Kuffel, Gina (NIH/NCI) [C]

  • 33 TB of data are now available in ICDC (five-fold increase since January)
  • TCL01: A multi-omics analysis of canine cancer cell lines
    • Testing complete
    • Waiting on 6 study-level files
  • PRECINCT has used templates available from the ICDC Data Model Explorer (DME) for the first ever load of a study via submitter-generated loading files
    • Data includes program, study, and and complete case records.
    • No sample records or files derived from samples yet.
  • SAC approved new data submission request from Dawn Duval’s group: “Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma”. (26 tumor normal pairs)
  • Kick-off call for OSA02
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

September Steering Committee Updates

Unknown User (parchmentr)

  • Minutes to be posted
  • Next meeting is October 19th
ICDC Site Updates

Kuffel, Gina (NIH/NCI) [C]

  • Next software release targets October 17th
    • Multi-file select for JBrowse
    • Elasticsearch
    • Data Model Explorer
      • ReadMe file and viewing modal 
      • TSV & JSON downloads of controlled vocabularies for properties with enumerated values
      • Node-specific tsv downloads
      • Faceted search augmented to include props featured on the UI
      • File transfer manifest to enable seamless file hand-offs
ICDC Next Phase Planning

Unknown User (hechtt)

Minutes (Not Verbatim)

TH - Will the PRECINCT program name remain the same, the reference is not indicative of the personnel or timeframes

CS - Maintaining an all-inclusive approach is the recommendation.

TH - Should we invite new PRECINCT members to the ICDC SC meeting? Previously we had Renee and Cheryl. Debbie is a constant and new awardee. People with database experience may be valuable to have.

CS - Jaime Modiano would be a good fit.

AL - Well-connected, asks great question, very introspective, good choice to invite Modiano.

CS - Other candidates would be David, Paul, Nikki, not sure of database experience.

TH - RFI response from Germany requesting circulating tumor cell data.


Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

TH- Possible COI with people working on the RFI and then responding to the RFI. Dr. Doroshow signed off on RFI. Unless there are issues noted the RFI should be published in ~ 2 weeks. Many ideas came from initial focus groups. 

JO- What type of plans can be put in place to advertise the RFI? Can we leverage NCI social media?

TH- We can send to anyone we want, including Cancer Center Directors, they have collaborations with vet clinic schools, some of the foundations.

AL- Circulate to PRECINCT as well.

TH- Deadline for response is Dec. 1st.

AL- Giving presentation to the children's oncology group. Touched base with CIN and PRECINCT. The talk is osteo-focused.


Action items

  • Unknown User (parchmentr) to add agenda item to ICDC Steering Committee to propose inviting selected PRECINCT members to the SC.