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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Musk, Philip (NIH/NCI) [C]

X
Warren KibbeX
Kim, Erika (NIH/NCI) [E]

X
Gregory TawaX
William Hendriks

Matthew Breen

Roel Verhaak



Goals

  • Review, discuss, and prioritize ICDC study submission proposals

Outstanding Action items

  • Matthew & Warren to write an email request to Toby pertaining to formalization of a business plan for ICDC
  • Kuffel, Gina (NIH/NCI) [C] to work with Phil add description for NCATS DPI (supported clinical sequencing)

Agenda

Discussion ItemWhoNotes
Study Queue

Musk, Philip (NIH/NCI) 

  • New Data Submission Request: 
    • Osteosarcoma study from Auburn University
    • 7 cases
    • Clinical and Transcriptomic data
  • COTC021: Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma
    • This is the parallel arm to COTC022: SOC in dogs with Osteosarcoma that was previously uploaded to the ICDC
    • Clinical data for 152 dogs. mRNAseq for 93 dogs
    • Status: Approved by SAC on 6/30/23, Template-based data loading files have been received
  • UBC03
    • Approved by SAC on 8/13/22
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • Purdue University
    • 19 cases
    • Status: v2 template-based data loading files have been reviewed, v3 files have been received
  • OSA02
    • Approved by SAC on 9/22/22
    • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma"
    • Colorado State University
    • 108 cases
    • Status: Submitters generating template-based loading files, reviewing hospital records to extract staging information and progression/survival data
  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Loaded into the Dev environment and indexing to be submitted to DCF this week, data preview conducted, embargo lifted, in the hands of QA team.
  • PRECINCT01 
    • Approved by SAC on 6/28/22
    • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases"
    • UC Davis
    • 21 cases
    • Status: Most data not yet available, pathology reports have been fully redacted and adverse event metadata coming soon, some files have been transferred, bucket permissions resolved, cytokine data is now available
  • PRECINCT02
    • Approved by SAC on 12/8/22
    • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
    • Tufts University
    • 49 cases
    • Status: Submitter has generated version 2 of template-based data loading files
  • PANCAN01
    • Approved by SAC on 11/8/21
    • "Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds"
    • University of Georgia
    • 684 cases
    • Status: Submitters generating template-based loading files, data manager PoC has been identified, candidate study has been identified to move forward

Minutes (Not Verbatim)


WK - let move the Auburn study to a formal vote within DGAB.

Warren and Greg have voted in favor, Gina to collect votes from other members through email.


Action items

  • Full publication details needed from Matthew Breen for UC01