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Click Samples and Search Existing Samples.
Fill in criteria, and click Search.
Click Edit in the search results.
The Navigation Tree appears on the left sidebar and comprises functions which you can use to add annotations to the sample.
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Understanding the Navigation Tree Abrev
Understanding the Navigation Tree Abrev
Click Characterization.
The All tab displays characterizations already added to the sample by category. Additional tabs show annotations added to the sample for each subcategory.
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SubmittingCharacterizations
SubmittingCharacterizations
Submitting Characterizations

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Access a sample and characterization.
Click All or the Physico-Chemical Characterizations tab and click Add next to Physico-chemical Characterization. Both tabs display five sections, but All provides customizations based what you select in the Characterization Type* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

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	AddPhysicoChemical
	AddPhysicoChemical

Section	What to Do
Physico-Chemical Characterization	Fill in the general information about the characterization.
[Characterization] Properties	Displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Finding	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to other Samples...	Select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

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	Other options
	Other options

Field	Description
Characterization Type*	The Characterization Type is already selected as Physico-Chemical Characterization.
Characterization Name*

Select from the drop-down list the

You must select the name of the Characterization you want to add

(required).

or select an "other" option to create a new or select from an existing, non-standard Assay Type.

To select an existing, non-standard Assay Type, based on Characterization Type, select other_pc.
To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list.
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Assay Type

The field populates automatically with your selection in Characterization Name.

With Characterization Name, other_pc, select from existing, non-standard Assay Types.
With Characterization Name, other, create a new, non-standard Assay Type.

Protocol Name – Version

If this field is available, select from the drop-down list the

Assay TypeThe field populates automatically with your selection in the Characterization field.Protocol Name – VersionIf this field is available, select from the drop-down list the

protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Characterization Source	Select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization Date	Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define Physico-Chemical Properties.

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	Other options
	Other options

Characterization	Property Fields	Field Options
Physical State	Type	Select the appropriate type from among the following options: colloid-emulsion colloid-gel colloid-sol fluid-gas fluid-liquid fluid-vapor solid-crystal solid-fibril solid-glass solid-granule solid-powder
Shape Properties	Type (required)	Select from the drop-down list the appropriate shape type: 2D-circle 2D-diamond 2D-ellipse 2D-parallelogram 2D-polygon 2D-rectangle 2D-square 2D-trapezoid 2D-triangle 3D-cone 3D-cube 3D-cylinder 3D-disc 3D-fibril 3D-hexadron 3D-needle 3D-oblate spheroid 3D-polyhedron 3D-prolate spheroid 3D-rod 3D-sphere 3D-tetrahedron 3D-tetrapod
Shape Properties	Aspect Ratio	Enter the shape aspect ratio.
Shape Properties	Minimum,/Maximum Dimensions	Enter the minimum and maximum dimensions of the sample, as well as the units of measurement.
Solubility Properties	Solvent	Select from the options or enter the name. alcohol phosphate-buffered saline saline water

Solubility

Solubility Properties

Critical Concentration

Enter appropriate values for the critical concentration, then select the appropriate units for those values.

Solubility

Solubility Properties	Is Soluble?	Select Yes or No as to whether the solvent is soluble.
Surface Properties	Is Hydrophobic?	Indicate with Yes or No whether the surface is hydrophobic.

Continue to define Physico-Chemical Design and Methods.

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	Other options
	Other options

Design and Methods Field	Description
Design and Methods Description	Enter a description for the characterization design and methods.

Technique and Instrument

Info

Include PageTechnique and instrumentTechnique and instrument

Technique*

Include PageTechniqueTechnique

title	Extra lines add

If you include an extra line between text in the Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

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	Technique and instrument
	Technique and instrument

Technique*

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	Technique
	Technique

Abbreviation

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	Abbreviation
	Abbreviation

Description

Enter a description of the technical and instrument.

Instrument

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	Instrument
	Instrument

Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

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	Data and conditions1
	Data and conditions1

Column Type "Datum" is selected with this characterization	Autopopulated Column Name Option[s]
Molecular Weight	Molecular Weight
Purity	% purity for sample
Relaxivity	R1, R2, T1, T2
Size	PD1, Peak N , RMS size, Z Average
Surface	charge, surface area, zeta potential

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	Data and conditions2
	Data and conditions2

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Access a sample and characterization.
Click All or the In Vitro Characterizations tab and click Add next to In Vitro Characterization. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

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	AddInVitroCharacterization
	AddInVitroCharacterization

Field/Section	What to Do
In Vitro Characterization	Fill in the general information about the characterization.
[Characterization] Properties ]	Displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Finding	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to Other Samples...	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

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	Other options
	Other options

Field	Description
Characterization Type*	The Characterization Type is already selected as In Vitro Characterization.
Characterization Name*

Select from the drop-down list

You must select the name of the Characterization you want to add

(required).Assay Type

This field populates automatically with options that display only for these in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting.

Select an option, if appropriate, or if there are none or if you prefer, select [Other] to name the assay type.

Protocol Name – Version

If this field is available, select from the drop-down list the protocol from which the data is derived.

A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).

Characterization SourceSelect from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).Characterization DateSelect from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to In Vitro Properties.

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Assay Type Options for In Vitro Characterizations

Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.

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Characterization Selection

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Assay Type Corresponding to Characterization

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Blood Contact

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Cytotoxicity

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Immune Cell Function

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Oxidative stress

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Sterility

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Targeting

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Cell binding/Internalization

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Transfection

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Click [Other] to add an assay type.

or select an "other" option to create a new or select from an existing, non-standard Assay Type. To select an existing, non-standard Assay Type, based on Characterization Type, select other_vt. To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list. Image Added
Assay Type	The field populates automatically with options displayed for in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. With Characterization Name, other_vt, select from existing, non-standard Assay Types. With Characterization Name, other, create a new, non-standard Assay Type.
Protocol Name – Version	If available, select the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
Characterization Source	Select or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization Date	Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to In Vitro Properties.

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Assay Type Options for In Vitro Characterizations

Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.

Characterization Selection	Assay Type Corresponding to Characterization
Blood Contact	Coagulation Complement Activation Hemolysis Plasma Protein Binding Platelet Aggregation
Cytotoxicity	Caspase 3 apoptosis Cell viability Gene expression Mitochondrial function Mitochondrial membrane potential Proliferation
Immune Cell Function	CFU – GM Chemotaxis Cytokine induction Cytotoxic activity Leukocyte proliferation Oxidative Burst Phagocytosis
Oxidative stress	GSH homeostasis Lipid peroxidation ROS generation
Sterility	Bacterial/yeast/mold Endotoxin Mycoplasma
Targeting	Cell binding/Internalization
Transfection	Click [Other] to add an assay type.

Continue to define in vitro characterizations.

Defining In Vitro [Characterization] Properties

The [Characterization] Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.

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	Other options
	Other options

For Cytotoxicity, enter the appropriate Cell Line.

For Enzyme Induction, enter your name of choice.
For Transfection, enter the appropriate Cell Line.

For Targeting, enter the appropriate Cell Line.

Continue to define In Vitro Design and Methods.

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Defining In Vitro Design and Methods

Fill in the following Design and Methods information as needed.

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	Other options
	Other options

Design and Methods Field

Description

Design and Methods Description

Enter a description for the characterization design and methods.

Info

title	Extra lines add

If you include an extra line between text in the Design and Methods Description, the line separation is preserved when you save or update the characterization.

Technique and Instrument

Include Page

	Technique and instrument
	Technique and instrument

Technique*

Include Page

	Technique
	Technique

Abbreviation

Include Page

	Abbreviation
	Abbreviation

Description

Enter a description of the technique and instrument.

Instrument

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	Instrument
	Instrument

Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

Continue to define In Vitro Findings.

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Describing Findings for an In Vitro Characterization

In the Finding sections, you can add one or more publications relevant to the sample, as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.

Click Add to expand the section, then add data and conditions and add a file.

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Adding Data and Conditions

In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information, such as laboratory conditions that are part of your findings

Continue to define in vitro characterizations.

Defining In Vitro [Characterization] Properties

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For Cytotoxicity, enter the appropriate Cell Line.

For Enzyme Induction, enter your name of choice.
For Transfection, enter the appropriate Cell Line.

Continue to define In Vitro Design and Methods.

Return to top

Defining In Vitro Design and Methods

Fill in the following Design and Methods information as needed.

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	Other options
	Other options

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Technique and Instrument

...

Technique*

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Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

Continue to define In Vitro Findings.

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Describing Findings for an In Vitro Characterization

Click Add to expand the section, then add data and conditions and add a file.

Return to top

Adding Data and Conditions

In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information, such as laboratory conditions that are part of your findings.

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To define the matrix for the data

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Enzyme Induction

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% of Control

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After adding data and conditions to the sample, add an In Vitro Characterization.

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Adding a File

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In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.

To add an in vivo characterization

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Click the All or In Vivo Characterizations tab and click Add next to In Vivo Characterizations. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

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Add data findings and supporting documentation relating to the sample.

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Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

To define the matrix for the data

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	Data and conditions1
	Data and conditions1

- - - Column Type "Datum" is selected with this characterization Autopopulated Column Name Option[s]
      Enzyme Induction
      % of Control

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	Data and conditions2
	Data and conditions2

After adding data and conditions to the sample, add an In Vitro Characterization.

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Adding a File

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	Adding a file
	Adding a file

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Anchor
InVivo
InVivo
Adding an In Vivo Characterization

In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.

To add an in vivo characterization

Access a sample and characterization.
Click the All or In Vivo Characterizations tab and click Add next to In Vivo Characterizations. Both tabs display five sections, but the All tab provide customizations based what you select in the Characterization* field.

Follow these steps to fill in the characterization. Links are provided for additional details.

Anchor

	Defining an In Vivo Characterization
	Defining an In Vivo Characterization

Field/Section	What to Do
In Vivo Characterization	Fill in the general information about the characterization.
[Characterization] Properties	Displays for in vivo characterizations.
Design and Methods	Complete the fields describing techniques and instruments used to derive the data.
Findings	Add data findings and supporting documentation relating to the sample.
Analysis and Conclusions	Enter any relevant analyses and conclusions reached by the data.
Copy to Other Samples...	Select samples in the list to which you want this physico-chemical data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact.

When you finish, click Submit to save the data to the sample.

Return to top

Defining an In Vivo Characterization

Fill in the following characterization information.

Include Page

	Other options
	Other options

Field

Description

Characterization Type*

The Characterization Type is already selected as In Vivo Characterization.

Characterization Name*

You must select the name of the Characterization you want to add or select an "other" option to create a new or select from an existing, non-standard Assay Type.

Info
If you select Pharmacokinetics and Toxicology, there are no customizations on this Characterization page based on either of these selections.

To select an existing, non-standard Assay Type, based on Characterization Type, select other_vv or other_ex_vv.
To create a new, non-standard Assay Type, select other. Enter a New Characterization Name, and click Add. The new characterization is added the Characterization Name list.
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Assay Type

Leave this blank or select a type.

With Characterization Name, other_vv or other_ex_vv, select from existing, non-standard Assay Types.
With Characterization Name, other, create a new, non-standard Assay Type

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When you finish, click Submit to save the data to the sample.

Return to top

Defining an In Vivo Characterization

Fill in the following characterization information.

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FieldDescriptionCharacterization Type*

The Characterization Type is already selected as In Vivo Characterization.

Characterization Name*Select from the drop-down list the name of the Characterization you want to ad (required). The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.Assay TypeLeave this blank or select a type

.
Protocol Name – Version	Select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
Characterization Source	Select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
Characterization Date	Select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

Continue to define In Vivo Design and Methods.

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Include Page

	Other options
	Other options

Design and Methods Field	Description
Design and Methods

Field

Description

Enter a description for the characterization design and methods.

Info

title	Adding extra lines

If you include an extra line between text in the Characterizations free text, Design and Methods Description, the line separation is preserved when you save or update the characterization

Description

Design and Methods Description

Enter a description for the characterization design and methods

Technique and Instrument

Include Page

	Technique and instrument
	Technique and instrument

Technique*

Include Page

	Technique
	Technique

Abbreviation

Include Page

	Abbreviation
	Abbreviation

Description

Enter a description of the technique and instrument.

Instrument

Include Page

	Instrument
	Instrument

Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.

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Managing Sample Composition Annotations | caNanoLab User's Guide| Managing Publications in caNanoLab

For Cytotoxicity, enter the appropriate Cell Line.

For Enzyme Induction, enter your name of choice.
For Transfection, enter the appropriate Cell Line.

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Old Version 81

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SubmittingCharacterizations
SubmittingCharacterizations
Submitting Characterizations

Assay Type Options for In Vitro Characterizations

Assay Type Options for In Vitro Characterizations

Defining In Vitro [Characterization] Properties

Defining In Vitro Design and Methods

Describing Findings for an In Vitro Characterization

Adding Data and Conditions

Defining In Vitro [Characterization] Properties

Defining In Vitro Design and Methods

Describing Findings for an In Vitro Characterization

Adding Data and Conditions

Adding a File

Adding a File

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InVivo
InVivo
Adding an In Vivo Characterization

Defining an In Vivo Characterization

Defining an In Vivo Characterization

Managing Sample Composition Annotations | caNanoLab User's Guide| Managing Publications in caNanoLab

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Old Version 81

New Version 82

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Assay Type Options for In Vitro Characterizations

Assay Type Options for In Vitro Characterizations

Defining In Vitro [Characterization] Properties

Defining In Vitro Design and Methods

Describing Findings for an In Vitro Characterization

Adding Data and Conditions

Defining In Vitro [Characterization] Properties

Defining In Vitro Design and Methods

Describing Findings for an In Vitro Characterization

Adding Data and Conditions

Adding a File

Adding a File

AnchorInVivoInVivoAdding an In Vivo Characterization

Defining an In Vivo Characterization

Defining an In Vivo Characterization

Managing Sample Composition Annotations | caNanoLab User's Guide| Managing Publications in caNanoLab

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Submitting Characterizations

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Adding an In Vivo Characterization