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1. Select the range type from the following options:
   
   • >=: Greater than the entered value
   • <=: Less than the entered value
   • Inside Range: Looks for all matching values that occur between the two levels you enter
   • Outside Range: Looks for all matching values that are not in between the two levels that you enter.
     The range of possible values is determined on the array side; the value is affected by the array type and the sample's behavior.
2. Enter the Expression Level appropriate for your query. The value that you enter is compared to the expression levels that are reported by the probes on the array platform. The probe value is typically a normalized value.This criteria changes slightly based the range type you select.
   The default value of 100 is a fixed default and does not reflect any values on the array. It simply represents a starting point for the query.

• To search for Gene Symbols, see Choosing Genes.

1. Continue with step 6 in Searching a caIntegrator Study.

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1. Select or enter data for the Fold change fields shown in the following figure and described below.
   
   • Gene Symbol - See #Gene Names Search.
   • Control Sample Set – If multiple platforms are part of the study, your platform selection in the Fold Change query criteria determines the control samples that are available.
     Select from the drop down list the name of the uploaded control sample set to serve as the fold change reference.
     
   • Regulation Type – Select the term that describes the gene expression in comparison with the control samples: Up is increased expression; Down is decreased expression; Up or Down is increased or decreased; Unchanged means no change in expression.
   • Up-regulation Folds – Enter a numerical value representing fold change. The number you enter here is dependent upon the Regulation Type you selected.
     
     • Up = Up Regulation Folds – Samples with a fold change greater than this value, when compared to the control samples, will be returned.
       
     • Down = Down Regulation Folds – Samples with a fold change less than this value, when compared to the control samples, will be returned.
       
     • Up or Down = Down Regulations Folds, Up Regulation Folds – Samples with a fold change either up or down, when compared to the control samples, will be returned.
       
     • Unchanged = Samples with a fold change between the two specified values will be returned.
       For example, if you enter 2.0 in this field, after selecting Up in the previous field, the search will locate genes whose expression is 2 times (2-fold up regulation) the base value.
2. To search for Gene Symbols, see Choosing Genes.
3. Continue with step 6 in Searching a caIntegrator Study.

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