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This section describes how to review or ascribe characterizations to samples that have been submitted to caNanoLab. This section includes the following topics:

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Understanding the Navigation Tree

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Characterization Characterization

[Sample] Characterization Overview

Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.

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Follow the links below for more information about entering characterization information for the sample of interest:

• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT

• Adding a Physico-chemical Characterization
• Adding an In Vitro Characterization
• Adding an In Vivo Characterization

See also Viewing Characterizations SummarySee also 5 - Managing Sample Characterizations 2.1 DRAFT

Submitting Characterizations

The page that opens after you click an Add button to add a characterization is very similar for all characterization types. The page differs only in the Properties section if there are special properties driven by the selection of characterization names. They also differ in the drop-down values for the column name in the Finding section driven by the characterization name and assay type selections.

Follow the links below for more information about entering characterization information for the sample of interest:

• Adding a Physico-chemical Characterization
• Adding an In Vitro Characterization
• Adding an In Vivo Characterization
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT

Adding a Physico-Chemical Characterization

 After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with Physico-Chemical Characterizations or select the Physico-Chemical Characterization tab where you can also click the Add button to add characterizations. The Physico-Chemical Characterization subcategory allows you to enter physical or chemical characterizations for the nanomaterial component of the sample.

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1. The Characterization type is already selected as Physico-Chemical Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add.
   For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining Physico-Chemical Characterization.
2. The [Characterization] Properties section displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable. For specific information, see   Defining Physico-Chemical [Characterization] Properties .
3. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining Physico-Chemical Design and Methods.
4. In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT . Describing Findings for Physico-Chemical Characterization .
5. In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
6. In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Copying Characterizations 2.1 DRAFT.
7. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

Defining Physico-Chemical Characterization

To continue defining Physico-Chemical Characterization fields, follow these steps.

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After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding a Physico-Chemical Characterization.

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Physico-Chemical Characterization Properties Physico-Chemical Characterization Properties

Defining Physico-Chemical [Characterization] Properties

The [Characterization] Properties section opens only for the characterizations listed in the table below. To define properties for the characterizations, complete the fields as described in the following table.

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After defining the [characterization] properties, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding a Physico-Chemical Characterization.

Defining Physico-Chemical Design and Methods

In the Design and Methods sections, complete the fields as described in the following table.

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Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding a Physico-Chemical Characterization.

Describing Findings for Physico-Chemical Characterization

In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.

Click Add to expand the section, then complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT Adding Data and Conditions and Adding a File.

Adding Data and Conditions

In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information such as laboratory conditions like pH or temperature that are part of your findings.

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After adding data and conditions to the sample, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding a Physico-Chemical Characterization.

Adding a File

After adding one or more files, continue by 5 - Managing Sample Characterizations 2.1 DRAFT Adding Data and Conditions or if you have no derived data to add, return to the steps described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding a Physico-Chemical Characterization.

Adding an In Vitro Characterization

After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vitro Characterizations or select the In Vitro Characterization tab where you can also click the Add button to add characterizations. The In Vitro Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.

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1. The Characterization type is already selected as In Vitro Characterization. In the Characterization Name* field in the upper right, select from the drop-down list the name of the Characterization you want to add (required).
   For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining an In Vitro Characterization.
2. The [Characterization] Properties section displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable. For specific information, see 5 - Managing Sample Characterizations 2.1 DRAFT Defining In Vitro Characterization Properties.
3. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining In Vitro Design and Methods.
4. In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Describing Findings for an In Vitro Characterization.
5. In the Analysis and Conclusions section, enter any relevant analyses and conclusions reached by the data.
6. In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Copying Characterizations 2.1 DRAFT.
7. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

Defining an In Vitro Characterization

To continue defining this characterization, follow these steps:

1. The Assay Type field populates automatically with options that display only for these in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. For details about these options, see 5 - Managing Sample Characterizations 2.1 DRAFT. Assay Type Options for In Vitro characterizations. Select an option, if appropriate, or if there are none or if you prefer, select [Other] to name the assay type.
2. If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
3. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
4. Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
5. In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.

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After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT. Adding an In Vitro Characterization.

Assay Type Options for In Vitro Characterizations

Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.

Defining In Vitro [Characterization] Properties

The [Characterization] Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.

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After defining the [characterization] properties, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.Adding an In Vitro Characterization.

Defining In Vitro Design and Methods

In the Design and Methods sections, complete the fields as described in the following table:

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Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT. Adding an In Vitro Characterization.

Describing Findings for an In Vitro Characterization

In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Click Add to expand the section, then complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT Adding Data and Conditions and Adding a File.

Adding Data and Conditions

In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information such as laboratory conditions that are part of your findings.

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After adding data and conditions to the sample, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding an In Vitro Characterization.

Adding a File

After adding one or more files, continue by or if you have no derived data to add, continue the process described in .

Adding an In Vivo Characterization

After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vivo Characterizations or select the In Vivo tab where you can also click the Add button to add characterizations. The In Vivo Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.

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1. The Characterization type is already selected as In Vivo Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add. The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.
   For more information about completing the Summary section, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining an In Vivo Characterization Summary.
   No [Characterization] Properties section displays for in vivo characterizations.
2. In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Defining In Vivo Design and Methods.
3. In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. Describing Findings for In Vivo Characterizations.
4. In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
5. In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Copying Characterizations 2.1 DRAFT.
6. When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.

Defining an In Vivo Characterization Summary

To continue defining Summary fields, follow these steps.

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After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT. Adding an In Vivo Characterization.

Defining In Vivo Design and Methods

In the Design and Methods sections, complete the fields as described in the following table.

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Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT. Adding an In Vivo Characterization.

Describing Findings for In Vivo Characterizations

In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.

Complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT. Adding Data and Conditions and Adding a File.

Adding Data and Conditions

In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information that are part of your findings.

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After adding data and conditions to the sample, continue the process described in .

Adding a File

After adding one or more files, continue by 5 - Managing Sample Characterizations 2.1 DRAFT Adding Data and Conditions or if you have no derived data to add, return to the steps described in 5 - Managing Sample Characterizations 2.1 DRAFT Adding an In Vivo Characterization.

Viewing Characterizations Summary

Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.

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caNanoLab lists characterizations that have been added to a sample under their corresponding Physical, In Vitro and In Vivo Characterization subcategories when you select the Characterization button on the Navigation Tree.

See also 5 - Managing Sample Characterizations 2.1 DRAFT. Characterization Tasks.

Characterization Tasks

From a characterization summary page, and with curator privileges, you can perform the following tasks:

• Printing a Characterization
• Exporting Characterizations
• Editing Characterizations
• Copying Characterizations
• Deleting a Characterization
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT
• 5 - Managing Sample Characterizations 2.1 DRAFT

Printing a Characterization

To print a characterization, follow these steps:

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Exporting Characterizations

To export a characterization, follow these steps:

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Editing Characterizations

To edit a characterization, follow these steps:

1. Open the sample of your choice.
2. In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
3. Click the Edit hypertext link at the right of the characterization section you want to change. This opens the corresponding Characterization page where you can edit the file by following the same directions as described for creating characterizations. For more information, see (Sample) Characterization Overview.

Copying Characterizations

The characterization files and/or derived data for this sample can be copied to other samples from the same primary point of contact.

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Deleting a Characterization

To delete a characterization for a selected sample, follow these steps:

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Publication Tasks Associated with a Sample

gation Tree button for an open sample, a Publication[s] summary page displays those publications associated with the sample, and the publication identifier, title, authors and year, where appropriate. Additionally, each publication category tab displays its corresponding publications.

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If you work from the Publications menu option, you can associate multiple samples with a publication. See Managing Publications. Alternatively, if you add publications to an open sample using the Navigation Tree option, you can use the copy feature to associate the publication with other samples in the same way you copy characterizations to multiple samples. See 5 - Managing Sample Characterizations 2.1 DRAFT Copying Characterizations.

For more information about adding a publication, see Submitting a Publication.

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