This section describes how to review or ascribe characterizations to samples that have been submitted to caNanoLab. This section includes the following topics:
You can perform the procedures described in this section only if you have curator status. If you have view only permissions, see 5 - Managing Sample Characterizations 2.1 DRAFT.
Understanding the Navigation Tree
[Sample] Characterization Overview
Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.
- Physico-chemical characterization refers to the characterization of physical and chemical properties of a sample.
- In vitro characterization refers to characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
- In vivo characterization refers to characterization for the nanomaterial component of the sample determined by the effect of samples on living cells.
In the Navigation Tree on the left sidebar, click the Characterization button. Five tabs showing characterization subcategories display on the page that opens. Select the Add button on the All tab that corresponds to the category of characterization annotations you want to add, or select the tab itself where you can add characterizations to the sample. The All tab displays any characterizations that have already been added to the sample; the characterization category tabs also display annotations specific to those categories.
You may have the option to add or delete function details with Add and Delete buttons. If you do not have certain security privileges, the Add and Delete buttons are hidden, and you have read-only access to the existing items.
Follow the links below for more information about entering characterization information for the sample of interest:
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
See also 5 - Managing Sample Characterizations 2.1 DRAFT
Submitting Characterizations
The page that opens after you click an Add button to add a characterization is very similar for all characterization types. The page differs only in the Properties section if there are special properties driven by the selection of characterization names. They also differ in the drop-down values for the column name in the Finding section driven by the characterization name and assay type selections.
Follow the links below for more information about entering characterization information for the sample of interest:
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
Adding a Physico-Chemical Characterization
After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with Physico-Chemical Characterizations or select the Physico-Chemical Characterization tab where you can also click the Add button to add characterizations. The Physico-Chemical Characterization subcategory allows you to enter physical or chemical characterizations for the nanomaterial component of the sample.
The page that opens is organized into five sections. This page is the same for all physico-chemical characterizations, except for slight customizations based what you select in the Characterization Type* field. Instructions for using the page are outlined in the steps below.
- The Characterization type is already selected as Physico-Chemical Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add.
For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. - The [Characterization] Properties section displays only for Physical State, Shape and Solubility characterizations. Define properties for the characterization, if applicable. For specific information, see Defining Physico-Chemical [Characterization] Properties .
- In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT .
- In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
- In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.
Defining Physico-Chemical Characterization
To continue defining Physico-Chemical Characterization fields, follow these steps.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
- The Assay Type field populates automatically with your selection in the Characterization field.
- If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
- For Characterization Source, select from the drop-down list or enter the source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
- In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Defining Physico-Chemical [Characterization] Properties
The [Characterization] Properties section opens only for the characterizations listed in the table below. To define properties for the characterizations, complete the fields as described in the following table.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
| Characterization | Property Fields | Field Options |
|---|---|---|
Physical State | Type | Select the appropriate type from among the following options: |
Shape Properties | Type (required) | Select from the drop-down list the appropriate shape type: |
Shape Properties | Aspect Ratio | Enter the shape aspect ratio. |
Shape Properties | Minimum,/Maximum Dimensions | Enter the minimum and maximum dimensions of the sample, as well as the units of measurement. |
Solubility Properties | Solvent | Select from the options or enter the name.
|
| Solubility Properties | Critical Concentration | Enter appropriate values for the critical concentration, then select the appropriate units for those values |
| Solubility Properties | Is Soluble? | Select Yes or No as to whether the solvent is soluble. |
Surface Properties | Is Hydrophobic? | Indicate with Yes or No whether the surface is hydrophobic. |
After defining the [characterization] properties, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Defining Physico-Chemical Design and Methods
In the Design and Methods sections, complete the fields as described in the following table.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
| Design and Methods Field | Description |
|---|---|
Description | Enter design and methods information not covered by other fields on the form. |
Technique and Instrument | Click Add to expand the page where you can select and enter information regarding the technique and instrument used to derive the sample. |
Technique* | Select the technique (required). |
| Abbreviation | When you select a technique, Abbreviation populates automatically if an abbreviation is known. If not, enter an abbreviation. |
| Description | Enter an appropriate description for the characterization design and methods. |
| Instrument | Click Add to expand the Instruments panel. Enter or select identifying information about the instrument used to obtain data.
|
Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Describing Findings for Physico-Chemical Characterization
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Click Add to expand the section, then complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding Data and Conditions
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information such as laboratory conditions like pH or temperature that are part of your findings.
To define the data and condition matrix, follow these steps.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
- Add data values to Data and Conditions.
- To import a file of data values
- Save the spreadsheet of data values to a csv (comma-separated value) file.
- Click Import csv and select and follow the prompts to add the data file to the Findings Info.
- The columns and data are added to Data and Conditions.
- To add the data values manually
- Specify the number of columns and rows for the matrix, and click Update.
- Add the data values to the rows.
- Specify the number of columns and rows for the matrix, and click Update.
Whether you imported or added information manually, you can preface each data value with one of the following: Maintain the default, equal to (=), or select greater than (>), less than (<), or infinity (approximate).
- To import a file of data values
- To define a column, click an underlined column heading.
The Column Definition panel displays.
Select a Column Type, Datum or Condition.
Select a Column Name or select other and add a new one.
Column Notes
You can add up to three cell viability Column Names, including cell viability, cell viability B, and cell viability C. You can further identify the column with the Column Value Type.For Column Type, Datum, the following characterization(s) display customized Column Name options.
Characterization Type Column Type and Column Name Option(s) Physico-Chemical - Molecular – Molecular Weight
- Purity – % purity for sample
- Relaxivity – R1, R2, T1, T2
- Size – PD1, Peak N , RMS size, Z Average
- Surface – charge, zeta potential
In Vitro Enzyme Induction – % of Control
In Vivo Click Other to name the column yourself. For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. The Column Name autopopulates the Condition Property options in the right column.
Column Type, Condition Autopopulates Column Name Column Name Autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Select a Column Value Unit, or select other and add one.
If you want the same value to fill all rows in a column, add a Constant Value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save in the Finding section.
| Column Type "Datum" is selected with this characterization | Autopopulated Column Name Option[s] |
|---|---|
Molecular Weight | |
Purity | |
Relaxivity | |
Size | |
Surface |
For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. Select a Column Name and the Condition Property options in the right column are available.
Column Type, Condition autopopulates
Column NameColumn Name autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Column Value Unit – Select a value unit, or select other and add one.
Constant Value – If you want the same value to fill all rows in a column, add a constant value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.
Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save on the Finding Info panel.
After adding data and conditions to the sample, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding a File
- In the Finding section, next to Files, click Add.
- Upload, browse, and select the file or enter the file's URL where the document is located.
- Complete the following.
- Select the File Type (required), Document, Graph, Image, Movie, or Spreadsheet.
- Enter the File Title (required).
- Specify Keywords to associate with the file
- Enter a Description of additional information of the file.
Click Submit to add the file(s) to the sample.
You can add as many files as you wish.
After adding one or more files, continue by 5 - Managing Sample Characterizations 2.1 DRAFT or if you have no derived data to add, return to the steps described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding an In Vitro Characterization
After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vitro Characterizations or select the In Vitro Characterization tab where you can also click the Add button to add characterizations. The In Vitro Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
The page that opens is organized into five sections. This page is the same for all in vitro characterizations, except for slight customizations based what you select in the Characterization* field. Instructions for using the page are outlined in the steps below.
- The Characterization type is already selected as In Vitro Characterization. In the Characterization Name* field in the upper right, select from the drop-down list the name of the Characterization you want to add (required).
For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT. - The [Characterization] Properties section displays only for Cytotoxicity, Enzyme Induction and Transfection in vitro characterizations. Define properties for the characterization, if applicable. For specific information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Analysis and Conclusions section, enter any relevant analyses and conclusions reached by the data.
- In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.
Defining an In Vitro Characterization
To continue defining this characterization, follow these steps:
- The Assay Type field populates automatically with options that display only for these in vitro characterization selections: Blood Contact, Cytotoxicity, Immune Cell Function, Oxidative Stress, Sterility and Targeting. For details about these options, see 5 - Managing Sample Characterizations 2.1 DRAFT. Select an option, if appropriate, or if there are none or if you prefer, select [Other] to name the assay type.
- If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists). However, protocol files are not required. Click the hyperlink to open or save the file.
- A hyperlink to the protocol text file should appear (if the protocol is not private to the user and the protocol file exists - ie. protocol files are not required).
- Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
- In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Assay Type Options for In Vitro Characterizations
Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.
Characterization Selection | Assay Type Corresponding to Characterization |
|---|---|
Blood Contact | |
Cytotoxicity | |
Immune Cell Function | |
Oxidative stress | |
Sterility | |
Targeting | |
Transfection | Click [Other] to add an assay type. |
Defining In Vitro [Characterization] Properties
The [Characterization] Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
- Cytotoxicity – Enter the appropriate Cell Line.
- Enzyme Induction – Enter your name of choice.
- Transfection – Enter the appropriate Cell Line.
After defining the [characterization] properties, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Defining In Vitro Design and Methods
In the Design and Methods sections, complete the fields as described in the following table:
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
| Design and Methods Field | Description |
|---|---|
Technique and Instrument | Click Add to expand the page where you can select and enter information regarding the technique and instrument used to derive the sample. |
Technique* | Select the technique (required). |
| Abbreviation | When you select a technique, Abbreviation populates automatically if an abbreviation is known. If not, enter an abbreviation. |
| Description | Enter an appropriate description for the characterization design and methods. |
| Instrument | Click Add to expand the Instruments panel. Enter or select identifying information about the instrument used to obtain data.
|
Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Describing Findings for an In Vitro Characterization
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Click Add to expand the section, then complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding Data and Conditions
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information such as laboratory conditions that are part of your findings.
To define the matrix for the data, follow these steps.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
- Add data values to Data and Conditions.
- To import a file of data values
- Save the spreadsheet of data values to a csv (comma-separated value) file.
- Click Import csv and select and follow the prompts to add the data file to the Findings Info.
- The columns and data are added to Data and Conditions.
- To add the data values manually
- Specify the number of columns and rows for the matrix, and click Update.
- Add the data values to the rows.
- Specify the number of columns and rows for the matrix, and click Update.
Whether you imported or added information manually, you can preface each data value with one of the following: Maintain the default, equal to (=), or select greater than (>), less than (<), or infinity (approximate).
- To import a file of data values
- To define a column, click an underlined column heading.
The Column Definition panel displays.
Select a Column Type, Datum or Condition.
Select a Column Name or select other and add a new one.
Column Notes
You can add up to three cell viability Column Names, including cell viability, cell viability B, and cell viability C. You can further identify the column with the Column Value Type.For Column Type, Datum, the following characterization(s) display customized Column Name options.
Characterization Type Column Type and Column Name Option(s) Physico-Chemical - Molecular – Molecular Weight
- Purity – % purity for sample
- Relaxivity – R1, R2, T1, T2
- Size – PD1, Peak N , RMS size, Z Average
- Surface – charge, zeta potential
In Vitro Enzyme Induction – % of Control
In Vivo Click Other to name the column yourself. For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. The Column Name autopopulates the Condition Property options in the right column.
Column Type, Condition Autopopulates Column Name Column Name Autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Select a Column Value Unit, or select other and add one.
If you want the same value to fill all rows in a column, add a Constant Value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save in the Finding section.
| Column Type "Datum" is selected with this characterization | Autopopulated Column Name Option[s] |
|---|---|
Enzyme Induction |
For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. Select a Column Name and the Condition Property options in the right column are available.
Column Type, Condition autopopulates
Column NameColumn Name autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Column Value Unit – Select a value unit, or select other and add one.
Constant Value – If you want the same value to fill all rows in a column, add a constant value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.
Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save on the Finding Info panel.
After adding data and conditions to the sample, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding a File
- In the Finding section, next to Files, click Add.
- Upload, browse, and select the file or enter the file's URL where the document is located.
- Complete the following.
- Select the File Type (required), Document, Graph, Image, Movie, or Spreadsheet.
- Enter the File Title (required).
- Specify Keywords to associate with the file
- Enter a Description of additional information of the file.
Click Submit to add the file(s) to the sample.
You can add as many files as you wish.
After adding one or more files, continue by or if you have no derived data to add, continue the process described in .
Adding an In Vivo Characterization
After you click the Characterizations button on the Navigation Tree, on the All tab click the Add button associated with In Vivo Characterizations or select the In Vivo tab where you can also click the Add button to add characterizations. The In Vivo Characterization subcategory allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.
The page that opens is organized into five sections. This page is the same for all in vivo characterizations. Instructions for using the page are outlined in the steps below.
- The Characterization type is already selected as In Vivo Characterization. In the Characterization Name field in the upper right, select from the drop-down list the name of the Characterization you want to add. The options for In Vivo Characterization are Pharmacokinetics and Toxicology. There are no customizations on this Characterization page based on either of these selections.
For more information about completing the Summary section, see 5 - Managing Sample Characterizations 2.1 DRAFT.
No [Characterization] Properties section displays for in vivo characterizations. - In the Design and Methods section, complete the fields describing techniques and instruments used to derive the data. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Finding section, add data findings and supporting documentation relating to the sample. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- In the Analysis and Conclusion section, enter any relevant analyses and conclusions reached by the data.
- In the Copy to Other Samples... section, select samples in the list to which you want this physico-chemical data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see 5 - Managing Sample Characterizations 2.1 DRAFT.
- When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.
Defining an In Vivo Characterization Summary
To continue defining Summary fields, follow these steps.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
- You can leave the Assay Type field blank or specify an Assay Type.
- If the Protocol Name – Version field is available, select from the drop-down list the protocol from which the data is derived. A hyperlink of the protocol text file may appear. Click the hyperlink to open or save the file.
- Select from the drop-down list or enter the Characterization Source from which the characterization data is derived, such as a vendor or a laboratory (NCL).
- In the Characterization Date field, select from the calendar or enter the date the characterization was made. Acceptable format: dd/mm/yyyy.
After defining the summary, continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Defining In Vivo Design and Methods
In the Design and Methods sections, complete the fields as described in the following table.
To enter an alternative to an option, select other if available and enter a value. The value is added to the list of options.
| Design and Methods Field | Description |
|---|---|
Description | Enter information not covered by other fields on the form. |
Technique and Instrument | Click Add to expand the page where you can select and enter information regarding the technique and instrument used to derive the sample. |
Technique* | Select the technique (required). |
| Abbreviation | When you select a technique, Abbreviation populates automatically if an abbreviation is known. If not, enter an abbreviation. |
| Description | Enter an appropropriate description for the design and methods. |
| Instrument | Click Add to expand the Instruments panel. Enter or select identifying information about the instrument used to obtain data.
|
Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue the process described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Describing Findings for In Vivo Characterizations
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Complete the instructions as described in 5 - Managing Sample Characterizations 2.1 DRAFT and 5 - Managing Sample Characterizations 2.1 DRAFT.
Adding Data and Conditions
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information that are part of your findings.
To define the matrix for the data, follow these steps:
- Add data values to Data and Conditions.
- To import a file of data values
- Save the spreadsheet of data values to a csv (comma-separated value) file.
- Click Import csv and select and follow the prompts to add the data file to the Findings Info.
- The columns and data are added to Data and Conditions.
- To add the data values manually
- Specify the number of columns and rows for the matrix, and click Update.
- Add the data values to the rows.
- Specify the number of columns and rows for the matrix, and click Update.
Whether you imported or added information manually, you can preface each data value with one of the following: Maintain the default, equal to (=), or select greater than (>), less than (<), or infinity (approximate).
- To import a file of data values
- To define a column, click an underlined column heading.
The Column Definition panel displays.
Select a Column Type, Datum or Condition.
Select a Column Name or select other and add a new one.
Column Notes
You can add up to three cell viability Column Names, including cell viability, cell viability B, and cell viability C. You can further identify the column with the Column Value Type.For Column Type, Datum, the following characterization(s) display customized Column Name options.
Characterization Type Column Type and Column Name Option(s) Physico-Chemical - Molecular – Molecular Weight
- Purity – % purity for sample
- Relaxivity – R1, R2, T1, T2
- Size – PD1, Peak N , RMS size, Z Average
- Surface – charge, zeta potential
In Vitro Enzyme Induction – % of Control
In Vivo Click Other to name the column yourself. For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. The Column Name autopopulates the Condition Property options in the right column.
Column Type, Condition Autopopulates Column Name Column Name Autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Select a Column Value Unit, or select other and add one.
If you want the same value to fill all rows in a column, add a Constant Value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save in the Finding section.
For an in vivo characterization, click [Other] to name the column yourself.
For Column Type, Condition, all characterizations provide the Column Name options in the left column of the following table. Select a Column Name and the Condition Property options in the right column are available.
Column Type, Condition autopopulates
Column NameColumn Name autopopulates
Condition PropertyN/A
media type, serum percentage
bandwidth, frequency, time, wavelength
N/A
lyophilized, time
time
N/A
N/A
lyophilized, time
ion concentration, ionic strength, molecular formula, osmolality, serum percentage, with serum
number of pulses, pulse duration
N/A
To further identify a column, select a Column Value Type.
Once the column information is saved, the Column Type is shown in parentheses after the Column Name, such as cell viability (mean).- Column Value Unit – Select a value unit, or select other and add one.
Constant Value – If you want the same value to fill all rows in a column, add a constant value.
For Column Value Type, boolean
For Column Value Type, boolean, enter a Constant Value of 1 for true and 0 for false.
Click Save, and the column(s) are updated.
If needed, click Set Column Order to change the order of the column headings in the matrix.
- Click Save on the Finding Info panel.
After adding data and conditions to the sample, continue the process described in .
Adding a File
- In the Finding section, next to Files, click Add.
- Upload, browse, and select the file or enter the file's URL where the document is located.
- Complete the following.
- Select the File Type (required), Document, Graph, Image, Movie, or Spreadsheet.
- Enter the File Title (required).
- Specify Keywords to associate with the file
- Enter a Description of additional information of the file.
Click Submit to add the file(s) to the sample.
You can add as many files as you wish.
After adding one or more files, continue by 5 - Managing Sample Characterizations 2.1 DRAFT or if you have no derived data to add, return to the steps described in 5 - Managing Sample Characterizations 2.1 DRAFT.
Viewing Characterizations Summary
Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.
- Physico-chemical characterization refers to the characterization of physical and chemical properties of a sample.
- In vitro characterization refers to characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
- In vivo characterization refers to characterization for the nanomaterial component of the sample determined by the effect of samples on living cells.
To view a sample characterizations summary, follow these steps:
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations link. Five tabs showing characterization subcategories display on the page that opens.
- The All tab displays characterizations that have already been added to the sample by category with anchor links to each. In addition, the characterization category tabs also display corresponding annotations.
caNanoLab lists characterizations that have been added to a sample under their corresponding Physical, In Vitro and In Vivo Characterization subcategories when you select the Characterization button on the Navigation Tree.
See also 5 - Managing Sample Characterizations 2.1 DRAFT.
Read only permissions?
If you have read only permissions, you will be able to view characterization but not perform associated tasks
Characterization Tasks
From a characterization summary page, and with curator privileges, you can perform the following tasks:
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
- 5 - Managing Sample Characterizations 2.1 DRAFT
Printing a Characterization
To print a characterization, follow these steps:
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
- Click the Print hypertext link at the top right of the page.
Read only access?
If buttons described in this section do not display, then you can assume that you have read-only access to the data.
Exporting Characterizations
To export a characterization, follow these steps:
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
- Click the Export hypertext link at the top right of the page.
Read only access?
If buttons described in this section do not display, then you can assume that you have read-only access to the data.
Editing Characterizations
To edit a characterization, follow these steps:
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
- Click the Edit hypertext link at the right of the characterization section you want to change. This opens the corresponding Characterization page where you can edit the file by following the same directions as described for creating characterizations. For more information, see (Sample) Characterization Overview.
Read only access?
If buttons described in this section do not display, then you can assume that you have read-only access to the data.
Copying Characterizations
The characterization files and/or derived data for this sample can be copied to other samples from the same primary point of contact.
To copy characterizations, open the sample characterization form that displays the characterization, and follow these steps:
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
- On the characterization summary page, click the Edit hypertext link at the right of the section you want to copy. This opens the corresponding Characterization page.
- At the bottom of the page, in the Copy to other samples... box, select one or more samples that have the same primary point of contact (those listed).
- Click the Also copy characterization results? box.
- Click Submit to execute the copy function.
Read only access?
If buttons described in this section do not display, then you can assume that you have read-only access to the data.
Deleting a Characterization
To delete a characterization for a selected sample, follow these steps:
Deleting a characterization
This only deletes the characterization(s) for the selected sample. If the characterization(s) is copied for other samples, the characterization will not be deleted.
- Open the sample of your choice.
- In the Navigation Tree on the left sidebar, click the Characterizations button. The All tab displays the characterizations summary.
- Click the Edit hypertext link at the right of the section you want to delete. This opens the corresponding Characterization page.
- Click the Delete button at the bottom left of the page.
Deleted characterizations are placed in the sample archive for history purposes.
Read only access?
If buttons described in this section do not display, then you can assume that you have read-only access to the data.
Publication Tasks Associated with a Sample
gation Tree button for an open sample, a Publication[s] summary page displays those publications associated with the sample, and the publication identifier, title, authors and year, where appropriate. Additionally, each publication category tab displays its corresponding publications.
Either on the Publications All tab or the subcategory tabs, you can perform these tasks:
- To access a publication, click the Abstract/Download hypertext link. This opens the document.
- To add a publication to the open sample, click the Add button corresponding to the publication type on the All tab or select a publication type tab and click the Add button. This opens the Submit Publication page identical to that opened from the Publications menu option with one exception:
If you work from the Publications menu option, you can associate multiple samples with a publication. See Managing Publications. Alternatively, if you add publications to an open sample using the Navigation Tree option, you can use the copy feature to associate the publication with other samples in the same way you copy characterizations to multiple samples. See 5 - Managing Sample Characterizations 2.1 DRAFT.
For more information about adding a publication, see Submitting a Publication.
For information about document details, see Searching Publications and other document topics in the Managing Publications section .
