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FNL Small Molecule Studies

These studies were acquired from Robert Kinders at Ft. Detrick on the recommendation of Ralph Parchment as a starting point for collecting data at the very beginning of the project and are a good representation of a clinical trials data model.

NCATS - Greg Tawa

Pre-medical Cancer Immunotherapy Network for Canine Trials (PRECINCT)

U24 Holder - Data Coordinating Center for U01 Holders

in cooperation with NCI COP and NCI program staff:
•Help develop and implement clinical studies
•Assist in standardization of clinical and laboratory protocols
•Manage clinical and correlative data and provide statistical support
•Facilitate sharing of agent, specimens and data

Institution

Project Leader(s)

Canine Cancer(s)

U Penn

Nicola Mason/Kathleen Propert

U24 coordinating center

UM1 Holders - Clinical Data

•Conduct canine clinical trials using immunotherapeutic agents and novel combinations
•Correlative studies to characterize and understand the cellular and molecular mechanisms that determine response (or non-response)

Institution

Project Leader(s)

Canine Cancer(s)

Colorado State U

Steven Dow/Cheryl London

Osteosarcoma, novel immunotherapy combinations

U of Alabama at Birmingham

MR Chambers

Glioma, immuno-neurotherapeutics

U of Minnesota

Grace Elizabeth Pluhar

Glioma, immunotherapy combinations

UC Davis

Robert Canter/Robert Rebhun

Melanoma and osteosarcoma, NK immunotherapy

Tufts U

Cheryl London/Kristy Richards

B-cell lymphoma, immunotherapy combinations


P30 Grant Holders - Genomic Data

In 2016 the NCI awarded 8 1-year supplements to support research in canine immunotherapy via collaborations between NCI-designated cancer centers and veterinary medical colleges

Goals included:
•Sequence (whole exome and RNAseq) of at least 25 canine tumors and their normal controls in one or more of the following tumors: B-cell lymphoma, glioma, osteosarcoma, melanoma, bladder cancer and mammary cancer
•Determine mutational load
•Characterize potential neoantigens that can bind canine MHC complexes
•Characterize T lymphocyte numbers and subsets and other relevant aspects of the tumor microenvironment in canine tumors

Institution

Project Leader(s)

Canine Cancer(s)

Baylor/U Florida Vet Med/Texas A&M/Tech U Denmark

Jonathan Levitt, PhD/Alan Herron, DVM

bladder, mammary, melanoma

U Colorado/Colorado State U Vet

Jill Slansky, PhD/Steven Dow, DVM, PhD

B-cell lymphoma

DFCI-HCC/Tufts U Vet Med

Katherine Janeway, MD/Cheryl London, DVM

osteosarcoma

Purdue U/Duke U

Deborah Knapp, DVM/H. Kim Lyerly, MD

bladder

Roswell Park/Cornell U Vet Med

Richard Koya, MD PhD/Kristy Richards, MD PhD

B-cell lymphoma

UC Davis/UC Davis Vet Med

Arta Monjazeb, MD PhD

glioma, melanoma, osteosarcoma

Ohio State U/OSU Vet Med/TGEN

Peter Shields, MD/Jeffrey Trent, PhD

melanoma, osteosarcoma

MD Anderson/Texas A&M

Amy Heimberger, MD/Jonathan Levine, DVM

glioma

P30 Grant holder:

Richard C. Koya, MD, PhD (email of 12/11/18):

Associate Director of the Center for Immunotherapy
Director of the Vector Development & Production Facility
Associate Professor of Oncology and Immunology

Roswell Park Comprehensive Cancer Center

Center for Immunotherapy
Elm and Carlton Streets, CCC-419
Buffalo, NY, 14263
Phone: (716) 845-1300, ext. 6582
Email: richard.koya@roswellpark.org

Bioinformatician

Sebastiano Battaglia, PhD
Assistant Professor of Oncology
Center For Immunotherapy
Assistant Member
Dept. of Cancer Genetic and Genomics
Roswell Park Comprehensive Cancer Center
Elm and Carlton sts.
14263, Buffalo, NY, USAA
p: +1 716 845 2300 ext. 5559
e: sebastiano.battaglia@roswellpark.org

P30 Grant holder

Deborah Knapp (email of 12/11/18): 

knappd@purdue.edu

Dhawan D, Hahn NM, Ramos-Vara JA, Knapp DW.  Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer.  PLoS Genet. 2018 Aug 8;14(8):e1007571. doi: 10.1371/journal.pgen.1007571. eCollection 2018 Aug. PMID: 30089113
 
Dhawan D, Paoloni M, Shukradas S, Choudhury DR, Craig BA, Ramos-Vara JA, Hahn N, Bonney PL, Khanna C, Knapp DW.  Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer. PLoS One. 2015 Sep 9;10(9):e0136688. doi: 10.1371/journal.pone.0136688. eCollection 2015. PMID: 26352142


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