What is caNanoLab?
Additional information on caNanoLab is available on the caNanoLab Wiki.
Who developed caNanoLab?
caNanoLab was developed as a collaboration between the NCI Center for Biomedical Informatics and Information Technology (CBIIT), the NCI Nanotechnology Characterization Laboratory (NCL), and the NCI Cancer Centers of Nanotechnology Excellence (CCNEs).
Does caNanoLab leverage any existing standards for describing nanoparticles and associated characterizations?
Standards supporting nanotechnology in the biomedical domain are emerging and under continuous development. caNanoLab leverages and extends concepts from existing standards developed by the biomedical and nanotechnology community. caNanoLab leverages biomedical and nanotechnology concepts from the NCI's Enterprise Vocabulary Services (EVS) and the Nanoparticle Ontology (NPO) developed by Washington University. The caNanoLab team works with the biomedical nanotechnology community to identify and define concepts identified during use case analysis. New concepts are maintained in the NCI Thesaurus.
Where can I find definitions for caNanoLab concepts?
How do I install my own caNanoLab system?
caNanoLab is available for download via the caNanoLab Wiki, in the Installations and Downloads section along with the Installation Guide and Release Note. The installation guide specifies general system requirements and instructions for installing the web application and database. All supporting documentation is available via the caNanoLab Wiki, Documentation and Training section.
What functionality does caNanoLab Support?
caNanoLab allows researchers to submit and retrieve information on nanoparticles and associated information including:
- The composition of the particle including nanoparticle entities (e.g. dendrimers, carbon nanotubes, quantum dots, etc.), functionalizing entities (therapeutic, targeting, and diagnostics entities), and chemical associations (chemical associations, attachments, or encapsulations between nanoparticle entities or functionalizing entities).
- Physical characterizations performed on a nanoparticle including size, molecular weight, shape, purity, etc.
- In vitro characterizations performed on a nanoparticle including cytotoxicity, immunotoxicity, and general toxicity characterization results.
- Protocols for characterizations performed on nanoparticles or general nanotechnology protocols from biomedical nanotechnology studies.
- Publications from biomedical nanotechnology studies.
caNanoLab provides secure access to data and requires authentication and authorization for access to non-public data.
How do I submit data into caNanoLab?
In order to submit data into caNanoLab, a user must have an account belonging to the data curator group. Users can register for a login account by selecting this option under “User Actions” on the caNanoLab homepage (https://cananolab.nci.nih.gov). Once a user has the appropriate account, the user can login to caNanoLab (https://cananolab.nci.nih.gov) and submit samples and associated characterizations, protocols, and publications.
|caNanoLab data submission workflow||caNanoLab composition and characterization concepts|
What types of data can I submit into caNanoLab?
caNanoLab provides support for a variety of different types of data including:
- Nanomaterials and their composition
- Nanomaterial Characterizations from physico-chemical characterizations
- Nanomaterial Chracterizations from in vitro characterizations
- Nanotechnology protocols
- Nanotechnology publications
Does caNanoLab directly link datasets to research articles?
In addition to associating samples with publication information stored in the the caNanoLab Data Portal, caNanoLab has established a direct reciprocal link between datasets and associated research articles published by Elsevier.
The current list of Elsevier journals that offer reciprocal linking include: Biomaterials, Cancer Letters, European Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Journal of Controlled Release, Materials Science and Engineering: C, Nanomedicine, Toxicology and Applied Pharmacology, Toxicology Letters, and Ultrasound in Medicine and Biology.
Elsevier journals that will offer reciprocal linking in the near future include: Biosensors and Bioelectronics, Colloids and Surfaces B: Biointerfaces, Journal of Magnetism and Magnetic Materials, European Journal of Pharmaceutics and Biopharmaceutics, Analytical Biochemistry: Methods in the Biological Sciences, European Journal of Cancer Supplements, Sensors and Actuators B: Chemical, Journal of Colloid and Interface Science, Analytica Chimica Acta, Carbohydrate Polymers, Talanta, Colloids and Surfaces A: Physicochemical and Engineering Aspects, Acta Biomaterialia, Biochemical and Biophysical Research Communications, Toxicology in Vitro, European Journal of Cancer, Biochemical Pharmacology, Pharmacological Research, Clinical Biochemistry, Magnetic Resonance Imaging, Photoacoustics, and Molecular and Cellular Probes.
Who can I contact to submit data into caNanoLab?
A data curator is available to assist in curating data from nanotechnology characterizations in biomedicine. Data curation activities on caNanoLab are currently performed by nanotechnology data scientists at Washington University and the Nanotechnology Characterization Laboratory (NCL). Data curators assist in extracting data from publications and nanotechnology experiments, annotating extracted data, and providing overall data quality control. If you are interested in depositing your data into caNanoLab, please contact NCI CBIIT App Support: Application Support Telephone: 240-276-5541 or toll free: 888-478-4423 Email: firstname.lastname@example.org
What is a caNanoLab site?
A caNanoLab site is an organization that maintains an instance of caNanoLab and participates in the sharing of data in a federated approach across the caBIG grid. caNanoLab search facilities allow users to retrieve publicly available data from diverse sites by selecting the site(s) when performing a caNanoLab search.